Quantitative structure - Activity relationships (QSARs) within series of inhibitors for mammalian cytochromes P450 (CYPs)

Journal of Enzyme Inhibition

Volumn 16, Issue 4, 2001, Pages 321-330

  Lewis, David F V ^a   Dickins, Maurice ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

CYP2A6; CYP2B1; CYP2C19; CYP2D6; CYP2E1; CYP51; CYPIA; Inhibitors; P450s; QSAR

Indexed keywords

CITALOPRAM; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2A6; CYTOCHROME P450 2B; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 INHIBITOR; DIAZEPAM; FLUCONAZOLE; ISOENZYME; KETOCONAZOLE; MENADIONE; METHOXSALEN; NORDAZEPAM; OMEPRAZOLE; ORPHENADRINE; OXPRENOLOL; PHENYTOIN; PILOCARPINE; PROPRANOLOL; QUINIDINE; STEROL 14ALPHA DEMETHYLASE; SULFAPHENAZOLE; SULFINPYRAZONE; TRANYLCYPROMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; WARFARIN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME STRUCTURE; HUMAN; LIPOPHILICITY; MAMMAL; MEMBRANE TRANSPORT; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

MAMMALIA;

EID: 0035690614     PISSN: 87555093     EISSN: None     Source Type: Journal    
DOI: 10.1080/14756360109162380     Document Type: Article

References (20)

1. "Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers and inhibitors"
2. "In vitro assessment of human cytochrome P450"
3. "An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials"
4. "Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes"
5. "Quantitative structure-activity relationships in substrates, inducers and inhibitors of cytochrome P4501"
6. "Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity"
7. "Molecular modelling of mammalian CYP2B isoforms and their interactions with substrates, inhibitors and redox partners"
8. "Structural determinants of P450 substrate specificity, binding affinity and catalytic rate"
9. "Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: Rationalization of substrate specificity and site-directed experiments in the CYP2C subfamily"
10. "Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: Structural studies on specific CYP2D6 substrate metabolism"
11. "Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: Investigation of the interactions of substrates and inhibitors within the putative active site of the CYP2E1 isoform"
12. "Molecular modelling of lanosterol 14α-demethylase (CYP51) from Saccharomyces cerevisiae via homology with CYP102, a unique bacterial cytochrome P450 isoform: Quantitative structure-activity relationships of antifungal agents"
13. "Inhibition of hepatic aryl hydrocarbon hydroxylase activity by a series of 7-hydroxycoumarins: QSAR studies"
14. "CYP2A6: A human coumarin 7-hydroxylase"
15. Quantitative structure-activity relationships (QSARs) within substrates of human cytochromes P450 involved in drug metabolism
16. "Quantitative structure-activity relationships in a series of alcohols exhibiting inhibition of cytochrome P450 mediated aniline hydroxylation"
17. "Inhibition of ethanol-inducible cytochrome P450IIE1 by 3-amino-1,2,4-triazole"
18. "Inhibition of p-nitrophenol hydroxylase in rat liver microsomes by small aromatic and heterocyclic molecules"