Differential acute and long term actions of succinic acid monomethyl ester exposure on insulin-secreting BRIN-BD11 cells

International Journal of Experimental Diabetes Research

Volumn 2, Issue 1, 2001, Pages 19-27

  Picton, Sally F ^a   Flatt, Peter R ^a   McClenaghan, Neville H ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

Clonal pancreatic beta cells; Glucose metabolism; Insulin secretion; Succinic acid monomethyl ester

Indexed keywords

2 OXOISOCAPROIC ACID; ALANINE; ANTIDIABETIC AGENT; ARGININE; GLUCOSE; GLYCERALDEHYDE; INSULIN; ISOBUTYLMETHYLXANTHINE; SUCCINIC ACID METHYL ESTER;

AEROBIC METABOLISM; ARTICLE; CELL FUNCTION; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EXPOSURE; DRUG MECHANISM; DRUG POTENCY; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLUCOSE UTILIZATION; INHIBITION KINETICS; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUTRIENT; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SECRETORY CELL; TIME;

1-METHYL-3-ISOBUTYLXANTHINE; AMINO ACIDS; ANIMALS; CAPROATES; CELL LINE; CELL SURVIVAL; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; KETO ACIDS; KINETICS; SUCCINATES;

EID: 0035690454     PISSN: 15604284     EISSN: None     Source Type: Journal    
DOI: 10.1155/EDR.2001.19     Document Type: Article

References (39)

1. Effects of carbohydrates on secretion of insulin form isolated rat pancreas
2. Insulin release in pancreatic islets by a glycolytic and Krebs cycle intermediate: Contrasting patterns of glyceralde-hyde and succinate
3. The regulation of amino acid transport in animal cells
4. Mechanisms of transport of amino acids across membranes
5. Regulatory and molecular aspects of mammalian amino acid transport
6. Glyceraldehyde phosphate and methyl esters of succinic acid. Two "new" potent insulin secretagogues
7. Respiratory, ionic, functional effects of succinate esters in pancreatic islets
8. The esters of carboxylic nutrients as insulinotropic tools in NIDDM
9. Stimulation of biosynthetic activity by novel succinate esters in rat pancreatic islets
10. 45calcium efflux and release from perifused rat pancreatic islets
11. Stimulation of insulin release in vivo by the methyl esters of succinic acid and glutamic acid
12. Insulinotropic action of monosaccharide esters: Therapeutic perspectives
13. Differences in the time course of the metabolic response of B and non-B pancreatic islet cells to D-glucose metabolized or non-metabolized hexose esters
14. New esters of succinic acid and mixed molecules formed by such esters and a meglitinide analog: Study of their insulinotropic potential
15. Metabolic effects and fate of succinic esters in pancreatic islets
16. In vivo stimulation of insulin release by succinic acid monomethyl esters
17. Comparison between the insulinotropic potential of ten new esters of succinic acid
18. Insulinotropic action of the monoethyl ester of succinic acid
19. Characterisation of a novel glucose responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion
20. Hexose recognition by insulin-secreting BRIN-BD11 cells
21. Mechanisms of amino acid induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line
22. Molecular characterization of the glucose-sensing mechanism in the clonal insulin secreting BRIN-BD11 cell line
23. D-Glucose metabolism in BRIN-BD11 islet cells
24. Insulin-releasing action of the novel antidiabetic agent BTS 67 582
25. Drug-induced desensitization of insulinotropic actions of sulfonylureas
26. Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide
27. Abnormal plasma glucose and insulin responses in heterozygous (ob/+) mice
28. Effects of glucose and other modifiers of insulin release on the oxidative metabolism of amino acids micro-dissected pancreatic islets
29. Insulin release by pancreatic islets
30. Frontiers of Insulin Secretion and Pancreatic B-Cell Research
31. 2-Ketoisocaproate transport in insulin-secreting cells
32. ATP channel-independent actions of keto acid initiators of insulin secretion
33. Effects of alpha-ketocarboxylic acids and 4-pentenoic acid on insulin secretion from the perfused rat pancreas
34. Changes of function and metabolism of the pancreatic B-cell caused by amino acids and related compounds
35. Signal function of metabolism of neutral amino acids and 2-keto acids for initiation of insulin secretion
36. Mechanisms of action of cationic amino acids on insulin secreting BRIN-BD11 cells
37. + cotransport by metabolizable and non-metabolizable amino acids stimulates a glucose-regulated insulin-secretory response
38. Suppressive effect of long-term sulphonylurea treatment on A, B and D cells of normal rat pancreas
39. Selective unresponsiveness of pancreatic beta cells to sulfonylurea stimulation during sulfonylurea therapy in NIDDM