New esters of succinic acid and mixed molecules formed by such esters and a meglitinide analog: Study of their insulinotropic potential

Pharmacological Research

Volumn 41, Issue 5, 2000, Pages 543-554

  Laghmich, A ^a   Ladriere, L ^a   Dannacher, H ^b   Bjorkling, F ^b   Malaisse, W J ^a  

^a FREE UNIVERSITY OF BRUSSELS   (Belgium)

^b LEO PHARMA A S   (Denmark)

Author keywords

Nateglinide; Rat pancreatic islet biosynthetic and secretory activity; Succinic acid esters

Indexed keywords

ANTIDIABETIC AGENT; HD 143; HD 154; HD 166; MEGLITINIDE; SUCCINIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG EFFECT; DRUG MECHANISM; DRUG SYNTHESIS; FEMALE; INSULIN LIKE ACTIVITY; INSULIN RELEASE; INSULIN SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033848090     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1999.0626     Document Type: Article

References (17)

1. Insulinotropic action of meglitinide analogs: Concentration-response relationship and nutrient dependency
2. The stimulus-secretion coupling of glucose-induced insulin release. VIII. Combined effects of glucose and sulfonylureas
3. The beta cell in non-insulin-dependent diabetes: Giving light to the blind
4. Effects of the methyl esters of pyruvate, succinate and glutamate on the secretory response to meglitinide analogues in rat pancreatic islets
5. Enhancement by succinic acid dimethyl ester of insulin release evoked by D-glucose and glimepiride in the perfused pancreas of normoglycemic and hyperglycemic rats
6. Potentiation of the insulinotropic and hypoglycemic action of gliquidone by succinic acid esters
7. Stimulation of insulin release and potentiation of the insulinotropic action of antidiabetic agents by 1,2,3-tri(methylsuccinyl)glycerol ester in anaesthetized rats
8. Enhancement of the insulinotropic action of glibenclamide by succinic acid methyl esters in anaesthetised rats
9. Comparison and synergism between the insulinotropic action of succinic acid monomethyl ester and N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine
10. Comparison between the insulinotropic potential of ten new esters of succinic acid
11. Stimulation of biosynthetic activity by novel succinate esters in rat pancreatic islets
12. Cytochalasin B-induced impairment of glucose metabolism in islets of Langerhans
13. Determination with glucose oxidase and peroxidase
14. Multiple effects of leucine on glucagon, insulin and somatostatin secretion from the perfused rat pancreas
15. Can glycerol-1,2,3-tris(methylsuccinate) stimulate insulin release after oral administration?
16. Synthesis of some phosphorylated amino-hydroxy-acids and derived peptides related to the phosphoproteins
17. N-(cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of oral hypoglycemic agents