Contortrostatin, a homodimeric disintegrin, actively disrupts focal adhesion and cytoskeletal structure and inhibits cell motility through a novel mechanism

Cell Adhesion and Communication

Volumn 8, Issue 2, 2001, Pages 71-86

  Ritter, Matthew R ^a   Zhou, Qing ^a   Markland Jr , Francis S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Disintegrin; Integrin; Motility; Vitronectin receptor; v 3

Indexed keywords

ACTIN; BETA3 INTEGRIN; CELL RECEPTOR; CONTORTROSTATIN; DISINTEGRIN; ECHISTATIN; FOCAL ADHESION KINASE; MONOCLONAL ANTIBODY;

ARTICLE; BASEMENT MEMBRANE; CANCER INVASION; CELL ADHESION; CELL MOTILITY; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CROSS LINKING; CYTOSKELETON; ENZYME LOCALIZATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR CELL;

EID: 0035682867     PISSN: 10615385     EISSN: None     Source Type: Journal    
DOI: 10.3109/15419060109080708     Document Type: Article

References (55)

1. Protein tyrosine phosphatase-PEST regulates Focal adhesion disassembly, migration, and cytokinesis in fibroblasts
2. Integrin alphavbeta3 mediates chemotactic and haptotactic motility in human melanoma cells through different signaling pathways
3. Effect of four disintegrins on the adhesive and metastatic properties of B16F10 melanoma cells in a murine model
4. Soluble ligands of the αvβ3 integrin mediate enhanced tyrosine phosphorylation of multiple proteins in adherent bovine pulmonary artery endothelial cells
5. Requirement of vascular integrin αvβ3 for angiogenesis
6. Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
7. Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity
8. Localization of matrix metallo-proteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3
9. Focal adhesions: Transmembrane junctions between the extracellular matrix and the cytoskeleton
10. FAK accompanies cell adhesion to extracellular matrix: A role in cytoskeletal assembly
11. Cas as a mediator of focal adhesion kinase-promoted cell migration
12. Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125 FAK
13. Altered actin cytoskeletal patterns in two premalignant stages in human colon carcinoma development
14. Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST
15. Integrin signaling
16. Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation
17. Trigramin: A low molecular weight peptide inhibiting fibrinogen interaction with platelet expressed on glycoprotein IIb-IIIa complex
18. A novel disintegrin salmosin inhibits tumor angiogenesis
19. Integrins and GTPases in tumour cell growth, motility and invasion
20. CAS/Crk coupling serves as a "Molecular Switch" for induction of cell migration
21. Signal transduction by integrins: Increased protein tyrosine phosphorylation caused by clustering of β1 integrins
22. Identification of a region in the integrin β3 subunit that confers ligand binding specificity
23. FAK in platelets
24. EC3, a novel heterodimeric disintegrin from Echis carinatus venom, inhibits α4 and α5 integrins in an RGD-independent manner
25. Structural and functional characterization of EMF10, a heterodimeric disintegrin from eristocophis macmahoni venom that selectively inhibits alpha 5 beta 1 integrin
26. Snake venom disintegrin: An effective inhibitor of breast cancer growth and dissemination
27. Integrin function: Molecular hierarchies of cytoskeletal and signaling molecules
28. Disintegrins and other naturally occurring antagonists of platelet fibrinogen receptors
29. Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle
30. Ussuristatin 2, a novel KGD-bearing disintegrin from Agkistrodon ussuriensis venom
31. Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival
32. Comparison of disintegrins with limited variation in the RGD loop in their binding to purified integrins αIIbβ3, αvβ3 and α5β1 and in cell adhesion inhibition
33. Tumorigenicity and Metastasis of human breast carcinoma cell Lines in nude mice
34. A New in vitro Assay for quantitating tumor cell invasion
35. Differential regulation of tyrosine phosphorylation in tumor cells by contortrostatin, a homodimeric disintegrin, and monomeric disintegrins echistatin and flavoridin
36. Contortrostatin, A snake venom disintegrin, induces αvβ3-mediated tyrosine phosphorylation of CAS and FAK in tumor cells
37. Why do so many stimuli induce tyrosine phosphorylation of FAK?
38. src
39. Metallothionein gene expression and resistance to cisplatin in human ovarian cancer
40. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
41. Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: Summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events
42. The nuclear magnetic resonance solution structure of flavoridin, an antagonist of the platelet GP IIb-IIIa receptor
43. Inhibition of angiogenesis in vitro and in vivo: Comparison of the relative activities of triflavin, an Arg-Gly-Asp-containing peptide and anti-αvβ3 integrin monoclonal antibody
44. Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration
45. Abciximab (ReoPro, chimeric 7E3 Fab) demonstrates equivalent affinity and functional blockade of GPIIb/IIIa and αvβ3 integrins
46. Contortrostatin, a snake venom disintegrin, inhibits β1 integrin-mediated human metastatic melanoma cell adhesion and blocks experimental metastasis
47. Purification and characterization of platelet aggregation inhibitors from snake venoms
48. cas signaling complex formation upon integrin-mediated cell adhesion: A role for Src family kinases
49. Alpha v integrins mediate adhesion and migration of breast carcinoma cell lines
50. Dissociation of FAK/p130(CAS)/c-Src complex during mitosis: Role of mitosis-specific serine phosphorylation of FAK
51. Accutin, a new disintegrin, inhibits angiogenesis in vitro and in vivo by acting as integrin αvβ3 antagonist and inducing apoptosis
52. Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits angiogenesis
53. Molecular cloning and functional expression of contortrostatin, a homodimeric disintegrin from southern copperhead snake venom
54. Contortrostatin, a homodimeric disintegrin, binds to integrin αvβ5
55. Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression