An intragenic methylated region in the imprinted Igf2 gene augments transcription

EMBO Reports

Volumn 2, Issue 12, 2001, Pages 1101-1106

  Murrell, Adele ^a   Heeson, Sarah ^a   Bowden, Lucy ^b   Constância, Miguel ^a   Dean, Wendy ^a   Kelsey, Gavin ^a   Reik, Wolf ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b Gardiner Caldwell Communications   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; LUCIFERASE; MESSENGER RNA; SOMATOMEDIN B;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DNA METHYLATION; FEMALE; GENE ACTIVATION; GENE DELETION; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC TRANSCRIPTION; GENOME IMPRINTING; INTRAUTERINE GROWTH RETARDATION; KNOCKOUT GENE; MALE; MOUSE; NONHUMAN; PARENT; PRIORITY JOURNAL; PROMOTER REGION; SILENCER GENE; TRANSCRIPTION REGULATION;

ALLELES; ANIMALS; DNA METHYLATION; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; GENES, REPORTER; GENOMIC IMPRINTING; INSULIN-LIKE GROWTH FACTOR II; MALE; MICE; MICE, KNOCKOUT; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0035680734     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kve248     Document Type: Article

References (34)

1. A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene
2. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
3. Methylation-induced repression-belts, braces and chromatin
4. The ontogeny of allele-specific methylation associated with imprinted genes in the mouse
5. Mechanisms of genomic imprinting
6. Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19
7. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
8. An upstream repressor element plays a role in Igf2 imprinting
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10. Imprinting and the epigenetic asymmetry between parental genomes
11. Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans
12. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
13. Three transitions in the RNA polymerase II transcription complex during initiation
14. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
15. The DNA methylation paradox
16. CpG islands as gene markers in the human genome
17. An enhancer deletion affects both H19 and Igf2 expression
18. DNA methylation differences associated with tumor tissues identified by genome scanning analysis
19. Transcription of RNA in isolated nuclei
20. Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2
21. Directed mutagenesis in embryonic stem cells
22. Genomic imprinting: Parental influence on the genome
23. Allelic methylation of H19 and IGF2 in the Beckwith-Wiedemann syndrome
24. Imprinting mutations in the Beckwith-Wiedemann syndrome suggested by altered imprinting pattern in the IGF2-H19 domain
25. DNA methylation inhibits elongation but not initiation of transcription in Neurospora crassa
26. Parental imprinting: Potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene
27. Growth-condition-dependent regulation of insulin-like growth factor II mRNA stability
28. The uniqueness of the imprinting mechanism
29. Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor
30. Rapid construction in yeast of complex targeting vectors for gene manipulation in the mouse
31. Overexpression of DNA methyltransferase in myoblast cells accelerates myotube formation
32. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2
33. Extensive tissue-specific variation of allelic methylation in the Igf2 gene during mouse fetal development: Relation to expression and imprinting