메뉴 건너뛰기




Volumn 949, Issue , 2001, Pages 6-15

Structure-function relationships in estrogen receptors and the characterization of novel selective estrogen receptor modulators with unique pharmacological profiles

Author keywords

Coactivators; ER ; ER ; SERMs

Indexed keywords

ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; LIGAND; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

EID: 0035680322     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb03998.x     Document Type: Conference Paper
Times cited : (54)

References (38)
  • 7
    • 0033513582 scopus 로고    scopus 로고
    • Dissection of the LXXLL nuclear receptor/coactivator interaction motif using combinatorial peptide libraries: Discovery of peptide antagonists of estrogen receptors alpha and beta
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 8226-8239
    • Chang, C.1    Norris, J.D.2
  • 10
    • 0025062215 scopus 로고
    • Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen
    • (1990) EMBO J. , vol.9 , pp. 2811-2818
    • Berry, M.1    Metzger, D.2
  • 13
    • 84995870933 scopus 로고
    • Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions
    • (1994) Mol. Endocrinol. , vol.8 , pp. 21-30
    • Tzukerman, M.T.1    Esty, A.2
  • 14
    • 0031789876 scopus 로고    scopus 로고
    • Transcription activation by the human estrogen receptor subtype β (ERβ) studied with ERβ and ERα receptor chimeras
    • (1998) Endocrinology , vol.139 , pp. 4513-4522
    • McInerney, E.M.1    Weis, K.E.2
  • 16
    • 0030801841 scopus 로고    scopus 로고
    • Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites
    • (1997) Science , vol.277 , pp. 1508-1510
    • Paech, K.1    Webb, P.2
  • 17
    • 0033305431 scopus 로고    scopus 로고
    • The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions
    • (1999) Mol. Endocrinol. , vol.13 , pp. 1672-1685
    • Webb, P.1    Nguyen, P.2
  • 18
    • 0032566547 scopus 로고    scopus 로고
    • Transcriptional regulation of the human quinone reductase gene by antiestrogen-liganded estrogen receptor-α and estrogen receptor-β
    • (1998) J. Biol. Chem. , vol.273 , pp. 25443-25449
    • Montano, M.M.1    Jaiswal, A.K.2
  • 19
  • 22
    • 0029058152 scopus 로고
    • The carboxyl-terminal F domain of the human estrogen receptor: Role in the transcriptional activity of the receptor and the effectiveness of antiestrogens as estrogen antagonists
    • (1995) Mol. Endocrinol. , vol.9 , pp. 814-825
    • Montano, M.M.1    Müller, V.2
  • 23
    • 0024330337 scopus 로고
    • Identification of cysteine-530 as the covalent attachment site of an affinity labeling estrogen (ketononestrol aziridine) and antiestrogen (tamoxifen aziridine) in the human estrogen receptor
    • (1989) J. Biol. Chem. , vol.264 , pp. 17476-17485
    • Harlow, K.W.1    Smith, D.N.2
  • 27
    • 0025797584 scopus 로고
    • Mutagenesis of cysteines in the hormone binding domain of the human estrogen receptor: Alterations in binding and transcriptional activation by covalently and reversibly attaching ligands
    • (1991) J. Biol. Chem. , vol.266 , pp. 10880-10887
    • Reese, J.C.1    Katzenellenbogen, B.S.2
  • 28
    • 0027067003 scopus 로고
    • Identification of two cysteines closely positioned in the ligand binding pocket of the human estrogen receptor: Roles in ligand binding and transcriptional activation
    • (1992) Mol. Endocrinol. , vol.6 , pp. 2160-2166
    • Reese, J.C.1    Wooge, C.H.2
  • 29
    • 0027424372 scopus 로고
    • Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast
    • (1993) J. Biol. Chem. , vol.268 , pp. 24089-24098
    • Wrenn, C.K.1    Katzenellenbogen, B.S.2
  • 30
    • 0029807308 scopus 로고    scopus 로고
    • Identification of amino acids in the hormone binding domain of the human estrogen receptor important in estrogen binding
    • (1996) J. Biol. Chem. , vol.271 , pp. 20053-20059
    • Ekena, K.E.1    Weis, K.E.2
  • 31
    • 0031040614 scopus 로고    scopus 로고
    • Different residues of the human estrogen receptor are involved in the recognition of structurally diverse estrogens and antiestrogens
    • (1997) J. Biol. Chem. , vol.272 , pp. 5069-5075
    • Ekena, K.1    Weis, K.E.2
  • 33
    • 0004752110 scopus 로고    scopus 로고
    • Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-α or estrogen receptor-β
    • (1999) Endocrinology , vol.140 , pp. 800-804
    • Sun, J.1    Meyers, M.J.2
  • 34
    • 0033744048 scopus 로고    scopus 로고
    • Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-alpha and estrogen receptor-beta: Correlations with biological character and distinct differences among SRC coactivator family members
    • (2000) Endocrinology , vol.141 , pp. 3534-3545
    • Kraichely, D.M.1    Sun, J.2
  • 35
    • 0344417000 scopus 로고    scopus 로고
    • Estrogen receptor subtype-selective ligands: Asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl-5,6,11,12-tetrahydrochrysenes
    • (1999) J. Med. Chem. , vol.42 , pp. 2456-2468
    • Meyers, M.J.1    Sun, J.2
  • 36
    • 0026726806 scopus 로고
    • Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation
    • (1992) J. Biol. Chem. , vol.267 , pp. 19513-19520
    • Allan, G.F.1    Leng, X.2
  • 37
    • 0031473542 scopus 로고    scopus 로고
    • Mechanistic aspects of estrogen receptor activation probed with constitutively active estrogen receptors: Correlations with DNA and coregulator interactions and receptor conformational changes
    • (1997) Mol. Endocrinol. , vol.11 , pp. 1375-1386
    • Lazennec, G.1    Ediger, T.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.