Differential MUC 1 expression in normal and neoplastic human pancreatic tissue: An immunohistochemical study of 60 samples

American Journal of Clinical Pathology

Volumn 112, Issue 5, 1999, Pages 635-640

  Monges, Genevieve M ^a   Mathoulin Portier, Marie Pierre A ^a   Acres, R Bruce ^b   Houvenaeghel, Gilles F ^a   Giovannini, Marc F ^a   Seitz, Jean François ^a   Bardou, Valerie Jeanne ^a   Payan, Marie Jose M ^a   Olive, Daniel ^c  

^a INSTITUT PAOLI CALMETTES   (France)

^b TRANSGENE S A   (France)

^c INSERM   (France)

Author keywords

Carcinoma; Diagnosis; Immunohistochemistry; MUC 1; Mucin; Pancreas

Indexed keywords

MONOCLONAL ANTIBODY; MUCIN;

ACINAR CELL CARCINOMA; ARTICLE; ASPIRATION BIOPSY; BENIGN TUMOR; CHRONIC PANCREATITIS; CONTROLLED STUDY; CYSTADENOCARCINOMA; DIAGNOSTIC VALUE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PANCREAS ADENOCARCINOMA; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0033492326     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcp/112.5.635     Document Type: Article

References (30)

1. Carraway KL, Hull SR. Cell surface mucin-type glycoproteins and mucin-like domains. Glycobiology. 1991;1:131-138.
2. Gum JR Jr. Mucin genes and the proteins they encode: structure, diversity and regulation. Am J Respir Cell Mol Biol. 1992;7:557-564.
3. Hilkens J, Ligtenberg MJL, Vos HL, et al. Cell membrane-associated mucins and their adhesion-modulating property. Trends Biochem Sci. 1992;17:359-363.
4. Gendler SJ, Burchell JM, Duhig T, et al. Cloning of partial cDNA encoding differentiation and tumor-associated mucin glycoproteins expressed by human mammary epithelium. Proc Natl Acad Sci U S A. 1987;84:6060-6066.
5. Gum JR, Byrd JC, Hicks JW, et al. Molecular cloning of human intestinal mucin cDNAs: sequence analysis and evidence for genetic polymorphism. J Biol Chem. 1989;264:6480-6487.
6. Gum JR, Hicks JW, Swallow DM, et al. Molecular cloning of cDNAs derived from a novel human intestinal mucin gene. Biochem Biophys Res Commun. 1990;171:407-415.
7. Porchet N, Nguyen VC, Dufosse J, et al. Molecular cloning and chromosomal localization of a novel human tracheobronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs. Biochem Biophys Res Commun. 1991;175:414-422.
8. Dufosse J, Porchet N, Audie JP, et al. Degenerate 87 base pair tandem repeats create hydrophilic/hydrophobic alternating domains in human peptide mucins mapped to 11p15. Biochem J. 1993;293:329-337.
9. Toribara NW, Roberton AM, Ho SB, et al. Human gastric mucin: identification of a unique species by expression cloning. J Biol Chem. 1993;268:5879-5885.
10. Bobek LA, Tsai H, Biesbrock AR, et al. Molecular cloning, sequence, and specificity of expression of the gene encoding the low moecular weight human salivary mucin (MUC7). J Biol Chem. 1993;268:20563-20569.
11. Hakomori SI. Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens. Adv Cancer Res. 1989;52:257-331.
12. Hollingsworth MA, Strawhecker JM, Caffrey TC, et al. Expression of MUC 1, MUC 2, MUC 3 and MUC 4 mRNAs in human pancreatic and intestinal tumor cell lines. Int J Cancer. 1994;57:198-203.
13. Ballague C, Gambus G, Carrato C, et al. Altered expression of MUC 2, MUC 4 and MUC 5 mucin genes in pancreas tissues and cancer cell lines. Gastrenterology. 1994;106:1054-1061.
14. Kotera Y, Darell Fontenot J, Pecher G, et al. Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients. Cancer Res. 1994;54:2856-2860.
15. Barnd DL, Lan M, Metzgar RS, et al. Specific, major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells. Proc Natl Acad Sci U S A. 1989;86:7159-7163.
16. Balloul JM, Acres RB, Geist M, et al. Recombinant MUC 1 vaccinia virus: a potential vector for immunotherapy of breast cancer. Cell Mol Biol. 1994;40:49-59.
17. Tsarfaty I, Chaitchik S, Hareunevi M, et al. H23 monoclonal antibody recognizes a breast tumor associated antigen: clinical and molecular studies. In: Ceriani RL, ed. Breast Cancer Immunodiagnosis and Immunotherapy. New York, NY: Plenum; 1989:161-189.
18. Acres RB, Hareuveni M, Balloul JM, et al. Vaccinia virus MUC 1 immunisation of mice: immune response and protection against the growth of murine tumor bearing the MUC 1 antigen. J Immunother. 1993;14:136-143.
19. Ballague C, Audie JP, Porchet N, et al. In situ hybridisation shows distinct pattern of mucin gene expression in normal, benign, and malignant pancreas tissues. Gastrenterology. 1995;109:953-964.
20. Wilkinson MJS, Howell A, Harris M. The prognostic significance of two epithelial membrane antigens expressed by human mammary carcinomas. Int J Cancer. 1984;33:299-304.
21. Byrne J, Horgan PG, England S. An evaluation of the usefulness of primary tumor expression of MCA and CA15-3 as prognostic indicators in breast carcinoma. Eur J Surg Oncol. 1992;18:230-234.
22. McGuckin MA, Walsh MD, Hohn BG, et al. Prognostic significance of MUC 1 epithelial mucin expression in breast cancer. Hum Pathol. 1995;26:432-439.
23. Ellis O, Bell J, Todd JM. Evaluation of immunoreactivity with monoclonal antibody NCRC11 in breast carcinoma. Br J Cancer. 1987;56-295-299.
24. Jerome KR, Barnd DL, Bendt KM. Cytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells. Cancer Res. 1991;51:2908-2916.
25. Rughetti A, Turchi V, Ghetti CA. Human B-cell immune response to the polymorphic epithelial mucin. Cancer Res. 1993;53:2457-2459.
26. Ligtenberg MJ, Buijs F, Vos HL. Suppression of cellular aggregation by high levels of episialin. Cancer Res. 1992;52:2318-2324.
27. Vilà MR, Balagué C, Real FX. Cytokeratins and mucins as molecular markers of cell differentiation and neoplastic transformation in the exocrine pancreas. Zentralbl Pathol. 1994;140:225-235.
28. Batra SK, Kem HM, Worlock AJ, et al. Transfection of the human MUC 1 mucin gene into a poorly differentiated human pancreatic tumor cell line, Pane 1: integration, expression and ultrastructural changes. J Cell Sci. 1991;100:841-849.
29. Terada T, Ohta T, Sasaki M, et al. Expression of MUC apomucins in normal pancreas and pancreatic tumours. J Pathol. 1996;180:160-165.
30. Henderson RA, Konitsky WM, Barratt-Boyes SM, et al. Retroviral expression of MUC-1 human tumor antigen with intact repeat structure and capacity to elicit immunity in vivo. J Immunother. 1998;21:247-256.