The target of molecular therapy on human colon cancer: DNA methylation and histone acetylation

Chinese Journal of Gastroenterology

Volumn 6, Issue 4, 2001, Pages 193-194

  Fang, J ^a   Xiao, S ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HISTONE;

ACETYLATION; COLON CANCER; DNA METHYLATION; EDITORIAL; GENE THERAPY; HUMAN; MOLECULAR BIOLOGY;

EID: 0035676656     PISSN: 10087125     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (19)

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2. Patterns of methylation of the c-myc gene in human colorectal cancer progression
3. Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia
4. Hypermethylation of the promoter region of the E-cadherin gene (CDH 1) in sporadic and ulcerative colitis associated colorectal cancer
5. Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggests a suppressor role in kidney, brain, and other human cancers
6. Methylation of CpG loci in 5′-flanking region alters steady-state expression of adenomatous polyposis coli gene in colon cancer cell lines
7. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
8. DNA methylation and genetic instability in colorectal cancer cells
9. Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression
10. Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells
11. Pharmacolkinetics of 5-aza-2′-deoxycytidine in animals and man: Relevance to clinical trials
12. Suppression of intestinal neoplasia by DNA hypomethylation
13. DNA methylation as a target for drug design
14. Butyrate enemas in experimental colitis and protection against large bowel cancer in a rat model
15. Butyrate inhibits seeding and growth of colorectal metastases to the liver in mice
16. Butyrate can act as a stimulator of growth or inducer of apoptosis in human colonic epithelial cell lines depending on the presence of alternative energy sources
17. Genes modulated by histone acetylation as new effectors of butyrate activity
18. Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors
19. Transient vs. prolonged histone hyperacetylation: Effects on colon cancer cell growth, differentiation, and apoptosis