Rac regulates vascular endothelial growth factor stimulated motility

Cell Adhesion and Communication

Volumn 8, Issue 1, 2001, Pages 1-13

  Soga, N ^a   Connolly, J O ^a   Chellaiah, M ^a   Kawamura, J ^a   Hruska, K A ^a  

^a BARNES JEWISH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CHEMOTAXIS ACTIVATOR; COLLAGEN; GUANOSINE TRIPHOSPHATASE; INTEGRIN; OSTEOPONTIN; RAC PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TETRACYCLINE; VASCULOTROPIN; VITRONECTIN;

ANIMAL CELL; ARTICLE; BRAIN; CELL CONTACT; CELL LINE; CELL MIGRATION; CELL MOTILITY; CELL STIMULATION; CHEMOTAXIS; COATED PARTICLE; CONTROLLED STUDY; CYTOSKELETON; ENDOTHELIUM CELL; EXPRESSION VECTOR; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; STRESS FIBER;

ANIMALIA; VECTORS;

EID: 0035672899     PISSN: 10615385     EISSN: None     Source Type: Journal    
DOI: 10.3109/15419060109080703     Document Type: Article

References (60)

1. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells
2. Src, ras, and rac mediate the migratory response elicited by NGF and PMA in PC12 cells
3. Platelet-derived growth factor and fibronectin-stimulated migration are differentially regulated by the Rac and extracellular signal-regulated kinase pathways
4. Signaling mechanisms in growth factor-stimulated cell motility
5. Effectors for the Rho GTPases
6. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis
7. Multiple roles for integrins during development
8. The small GTPases rho and rac are required for the establishment of cadherin-dependent cell-cell contacts
9. The role of vascular endothelial growth factor in blood vessel formation
10. Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscular cells, whereas hypoxia upregulates VEGF expression only
11. Osteopontin expression and distribution in human carcinoma
12. Inhibition of vascular endothelial growth factor-induced endothelial cell migration by ETS1 antisense oligonucleotides
13. Articular cartilage transplantation
14. Rac is essential in the transformation of endothelial cells by polyoma middle T
15. Identification of novel graded polarity actin filament bundles in locomoting heart fibroblasts: Implications for the generation of motil force
16. Osteopontin: A protein with diverse functions
17. Vascular endothelial growth factor induces VE-cadherin thyrosine phosphorylation in endothelial cells
18. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene
19. Vascular endothelial growth factor
20. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
21. 2 domains
22. Rho GTPases and the actin cytoskeleton
23. Inhibition of invasion of epithelial cells by Tiam1-rac signaling
24. Integrin signaling and cell growth control
25. Cdc42 and Rac 1 induce integrin-mediated cell motility and invasiveness through PI(3)K
26. Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins
27. Signaling by integrin receptors
28. Cell migration: A physically integrated molecular process
29. Integrin β1- and β3-mediated endothelial cell migration is triggered through distinct signaling mechanisms
30. Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro
31. Rho GTPases
32. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
33. Formation of transformed endothelial cells in the absence of VEGFR-2/Flk-1 by polyoma middle T oncogene
34. Endothelial receptor tyrosine kinases involved in angiogenesis
35. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells
36. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
37. Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell binding sequence
38. Cell-cell interaction by mouse limb cells during in vitro chondrogenesis: Analysis of the brachypod mutation
39. The effect of linomide on the migration and the proliferation of capillary endothelial cells elicited by vascular endothelial growth factor
40. An essential role for Rac in Ras transformation
41. Cellular ras gene activity is required for full neoplastic transformation by polyomavirus
42. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
43. Differential binding characteristics and cellular inhibition by soluble VEGF receptors 1 and 2
44. Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells
45. p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
46. 3 integrin, osteopontin, and thrombin
47. Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin
48. Vascular endothelial growth factor stimulates protein kinase C-dependent phospholipase D activity in endothelial cells
49. Role of VEGF-Flt receptor system in normal and tumor angiogenesis
50. A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice
51. Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain
52. ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect of the cell motility
53. Involvement of Rho p21 small-binding protein and its regulator in the HGF-induced cell motility
54. Oncogenes in the study of endothelial cell growth and differentiation
55. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
56. Receptor-ligand interaction between CD44 and osteopontin (Eta-1)
57. VEGF mRNA is reversibly stabilized by hypoxia and persistently stabilized in VEGF overexpressing human tumor cell lines
58. Embryonic lethalities and endothelial tumours in chimeric mice expressing polyoma middle T oncogene
59. Regulation of TNF-α-induced reorganization of the actin cytoskeleton and cell-cell junctions by rho, rac, and cdc42 in human endothelial cells
60. Differential endothelial migration and proliferation to basic fibroblast growth factor and vascular endothelial growth factor