Mutation at the CK2 phosphorylation site on Cdc28 affects kinase activity and cell size in Saccharomyces cerevisiae

Molecular and Cellular Biochemistry

Volumn 227, Issue 1-2, 2001, Pages 113-117

  Russo, G L ^a   Van Den Bos, C ^b   Marshak, D R ^c  

^a CNR   (Italy)

^b Martek Biosciences Corporation   (United States)

^c Cambrex Biosciences Group   (United States)

Author keywords

CDC28; Cell division cycle; Protein kinase CK2; Saccharomyces cerevisiae

Indexed keywords

ALANINE; CASEIN KINASE II; CELL CYCLE PROTEIN; CYCLIN A; GLUTAMIC ACID; PROTEIN HISTIDINE KINASE; PROTEIN KINASE; SERINE;

ANIMAL CELL; ARTICLE; BUDDING; CELL CYCLE; CELL CYCLE G1 PHASE; CELL DIVISION; CELL SIZE; CELL VOLUME; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE MUTATION; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; MAMMAL CELL; NONHUMAN; PROTEIN CONTENT; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; YEAST CELL;

ALANINE; AMINO ACID SEQUENCE; BINDING SITES; CASEIN KINASE II; CATALYTIC DOMAIN; CDC28 PROTEIN KINASE, S CEREVISIAE; CELL CYCLE; CYCLIN A; G1 PHASE; GENOTYPE; HISTONES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SERINE;

ANIMALIA; MAMMALIA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 0035670339     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1013189629207     Document Type: Article

References (37)

1. Casein kinases: Pleiotropic mediators of cellular regulation
2. Protein kinase CK2: An enzyme with multiple substrates and a puzzling regulation
3. Protein kinase CK2
4. CK2, a protein kinase of the next millennium
5. CK2: A protein kinase in need of control
6. Identification and characterization of protein kinase CKII isoforms in HeLa Cells
7. Structure of protein kinase CK2: Dimerization of the human β-subunit
8. Interactions of protein kinase CK2 subunits
9. Regulation of casein kinase II by growth factors - A reevaluation
10. On the physiological role of casein kinase II in Saccharomyces cerevisiae
11. Casein kinase II is required for cell cycle progression during G1 and G2/M in Saccharomyces cerevisiae
12. Isolation, sequencing, and distruption of the yeast CKA2 gene: Casein kinase II is essential for viability in Saccharomyces cerevisiae
13. cdc2 kinase in G1 phase of the HeLa cell division cycle
14. Regulation of protein kinase CKII during the cell division cycle
15. Primary structure homology between the product of yeast cell division control gene CDC28 and vertebrate oncogenes
16. Checkpoints: Controls that ensure the order of cell cycle events
17. Cell cycle regulation in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe
18. At the heart of the budding yeast cell cycle
19. Phosphorylation and proteolysis: Partners in the regulation of cell division in budding yeast
20. The cyclin family of budding yeast: Abundant use of a good idea
21. Exit from mitosis in budding yeast: Biphasic inactivation of the Cdc28-C1b2 mitotic kinase and the role of Cdc20
22. Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex
23. Cell cycle checkpoints: Preventing an identity crisis
24. S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34cdc28
25. Regulation of p34 CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae
26. Dephosphorylation of threonine 169 of Cdc28 is not required for exit from mitosis but may be necessary for Start in Saccharomyces cerevisiae
27. Tyrosine phosphorylation of Cdc2 is required for the replication checkpoint in Schizosaccharomyces pombe
28. Activating phosphorylation of the Saccharomyces cerevisiae cyclin-dependent kinase, cdc28p, precedes cyclin binding
29. Phosphorylation of Cdc28 and regulation of cell size by the protein kinase CKII in Saccharomyces cerevisiae
30. cdc2 protein kinase
31. Cell size modulation by CDC25 and RAS2 genes in Saccharomyces cerevisiae
32. cdc2 phosphorylation is required for its interaction with cyclin
33. A three-dimensional model of the Cdc2 protein kinase: Localization of cyclin- and Suc1-binding regions and phosphorylation sites
34. Mechanism of CDK activation revealed by the structure of a cyclin A-CDK2 complex
35. Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins