Onset of sex differentiation: Dialog between genes and cells

Archives of Medical Research

Volumn 32, Issue 6, 2001, Pages 553-558

  Merchant Larios, H ^a   Moreno Mendoza, N ^a  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS   (Mexico)

Author keywords

Gene expression; Gonads; Organogenesis; Sertoli cells; Sex differentiation

Indexed keywords

ALKALINE PHOSPHATASE; CADHERIN; CADHERIN P; CYTOCHROME P450; NERVE CELL ADHESION MOLECULE; NUCLEAR RECEPTOR DAX 1; PROTEIN; PROTEIN DHH; PROTEIN EMX 2; PROTEIN LIM 1; PROTEIN LIM 9; PROTEIN PATCHED; PROTEIN PN 1; PROTEIN VNN1; PROTEIN WT 1; STAGE SPECIFIC EMBRYO ANTIGEN 1; STEROIDOGENIC FACTOR 1; TESTIS DETERMINING FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR OCT 3 4; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG; UVOMORULIN; WNT1 PROTEIN;

AMINO TERMINAL SEQUENCE; CELL LINEAGE; CELL MIGRATION; CELL PROLIFERATION; GENE EXPRESSION; GENE TARGETING; GONAD DEVELOPMENT; LEYDIG CELL; MORPHOLOGY; NONHUMAN; PHENOTYPE; PRIMORDIAL GERM CELL; REVIEW; SERTOLI CELL; SEX DIFFERENTIATION; TESTIS;

ANIMALS; CASTRATION; CELL DIFFERENTIATION; CELL LINEAGE; CELL MOVEMENT; DNA-BINDING PROTEINS; FEMALE; FETAL PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, SRY; GERM CELLS; HOMEODOMAIN PROTEINS; HUMANS; LEYDIG CELLS; MALE; MAMMALS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MULLERIAN DUCTS; NUCLEAR PROTEINS; OVARY; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-KIT; SEMINIFEROUS EPITHELIUM; SERTOLI CELLS; SEX DETERMINATION (GENETICS); SEX DIFFERENTIATION; SEX-DETERMINING REGION Y PROTEIN; STEM CELL FACTOR; STROMAL CELLS; TESTIS; TRANSCRIPTION FACTORS; WOLFFIAN DUCT; Y CHROMOSOME;

EID: 0035668830     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0188-4409(01)00317-4     Document Type: Review

References (58)

1. Bmp4 is required for the generation of primordial germ cells in the mouse embryo
2. The onset of germ cell migration in the mouse embryo
3. Continuous patterns of c-kit and steel expression: Analysis of mutations at the W and Sl loci
4. Embryonic expression of a haematopoyetic growth factor encoded by the Sl locus and the ligand for c-kit
5. Developmental expression of c-kit, a proto-oncogene encoded by the W locus
6. Tissue non-specific alkaline phosphatase is expressed in both embyonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells
7. Immunohistochemical localization of the early embryonic antigen (SSEA-1) in postimplantation mouse embryos and fetal and adult tissues
8. The role of cadherins during primordial germ cell migration and early gonad formation in the mouse
9. Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonic cells
10. Expression and intracellular localization of mouse Vasa-homologue protein during germ cell development
11. The genetics of Wilms' tumor - A case of disrupted development
12. Alternative splicing and genomic structure of the Wilms tumor gene WT1
13. A non-AUG translation initiation event generates novel WT1 isoforms
14. Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing
15. The candidate Wilms' tumor gene is involved in genitourinary development
16. WT-1 is required for early kidney development
17. Steroidogenic factor 1, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor 1
18. Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily
19. A cell-specific nuclear receptor is essential for adrenal and gonadal development and for male sexual differentiation
20. Requirement for Lim 1 in head organizer function
21. The LIM homeobox gene Lhx9 is essential for mouse gonad formation
22. Recherches sur la différenciation sexuelle de l'embryon de lapin. III. Rôle des gonades fœtales dans la différenciation sexuelle somatique
23. Defects of urogenital development in mice lacking Emx2
24. Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Mullerian inhibiting substance promoter
25. Mouse Dax1 expression is consistent with a role in sex determination as well as adrenal and hypothalamus function
26. Male-to-female sex reversal in M33 mutant mice
27. Evidence for evolutionary conservation of sex determining genes
28. Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development
29. Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development
30. Origin of the somatic cells in the rat gonad: An autoradiographic approach
31. The Y chromosome as the bearer of male determining factor
32. The sex determining region of the human Y chromosome encodes a finger protein
33. A gene from the sex determining region encodes a protein with homology to a conserved DNA binding motif
34. Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins
35. Definition of a consensus DNA binding site for SRY
36. Architectural transcription factors
37. HMG domain proteins: Architectural elements in the assembly of nucleoprotein structures
38. Sex-reverse mutations affect the architecture of SRY-DNA complexes
39. The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains
40. In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination
41. Mammalian testis-determining genes. Sry and Sox9
42. Sex determination and the Y chromosome
43. Phosphorylation of an N-terminal motif enhances DNA-binding activity of the human SRY protein
44. Expression of a candidate sex-determining gene during mouse sex differentiation
45. Expression of Sry, the mouse testis determining gene
46. In situ analysis of fetal, prepuberal and adult XX↔XY chimaeric mouse testes: Sertoli cells are predominantly but not exclusively XY
47. Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds
48. A male-specific role for SOX9 in vertebrate sex determination
49. The role of the mesonephros in cell differentiation and morphogenesis of the mouse fetal testis
50. Mesonephric contribution to testis differentiation in the fetal mouse
51. Mesonephric stromal cells differentiate into Leydig cells in the mouse fetal testis
52. Sertoli cell signaling by desert hedgehog regulates male germ line
53. A subtractive gene expression screen suggests a role for Vanin-1 in testis development in mice
54. Germ cell differentiation in mouse adrenal glands
55. DAX-1 inhibits SF-1 mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita
56. Mouse Dax-1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function
57. DAX-1, an "antitestis" gene
58. Female development in mammals is regulated by Wnt-4 signaling