Hypoglycemia-associated autonomic failure in diabetes

American Journal of Physiology - Endocrinology and Metabolism

Volumn 281, Issue 6 44-6, 2001, Pages

  Cryer, Philip E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Epinephrine; Glucagon; Sympathetic nervous system

Indexed keywords

ADRENALIN; ANTIDIABETIC AGENT; GLUCAGON; GLUCOSE; INSULIN;

ADRENERGIC SYSTEM; AUTONOMIC DYSFUNCTION; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; GLUCOSE BRAIN LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; HYPOGLYCEMIA; IATROGENIC DISEASE; INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RISK FACTOR; SHORT SURVEY;

EID: 0035665510     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2001.281.6.e1115     Document Type: Short Survey

References (45)

1. Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release
2. A decrease in β-cell insulin secretion is a signal to increased α-cell glucagon secretion in response to hypoglycemia
3. A reliable and reproducible test for adequate glucose counterregulation in type I diabetes
4. Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxyglucose perfusion of the ventromedial hypothalamus in rats
5. Brain glucose uptake and unawareness of hypoglycemia in patients with insulin dependent diabetes mellitus
6. Adaptation in brain glucose uptake following recurrent hypoglycemia
7. Plasma glucose concentrations at the onset of hypoglycemic symptoms in patients with poorly controlled diabetes and nondiabetics
8. Restoration of hypoglycemia unawareness in patients with long duration insulin-dependent diabetes mellitus
9. Iatrogenic hypoglycemia as a cause of hypoglycemiaassociated autonomic failure in IDDM: A vicious cycle
10. The prevention and correction of hypoglycemia
11. Negotiating the barrier of hypoglycemia
12. Hypoglycemia-associated autonomic failure in insulin dependent diabetes mellitus
13. Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM
14. Counterregulatory adaptation to recurrent hypoglycemia in normal humans
15. Role of cortisol in the pathogenesis of deficient counterregulation after antecedent hypoglycemia in normal humans
16. Prevention of an increase in plasma cortisol during hypoglycemia preserves subsequent counterregulatory responses
17. Long-term recovery from unawareness, deficient counterregulation and lack of cognitive dysfunction during hypoglycemia following institution of rational intensive therapy in IDDM
18. Relative roles of insulin and hypoglycemia on induction of neuroendocrine responses to, symptoms of, and deterioration of cognitive function in hypoglycemia in male and female humans
19. Impact of nocturnal hypoglycemia on hypoglycemic cognitive dysfunction in type 1 diabetes mellitus
20. Correlation between minimal secretory capacity of pancreatic β-cells and stability of diabetic control
21. Effects of antecedent prolonged exercise on subsequent counterregulatory responses to hypoglycemia
22. Lack of glucagon response to hypoglycemia in diabetes: Evidence for an intrinsic pancreatic alpha cell defect
23. Frequency of severe hypoglycemia in patients with type 1 diabetes with impaired awareness of hypoglycemia
24. Reduced neuroendocrine and symptomatic response to subsequent hypoglycemia after one episode of hypoglycemia in nondiabetic humans
25. Frequency and symptoms of hypoglycemia experienced by patients with type 2 diabetes treated with insulin
26. Glycated haemoglobin, diabetes and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC-Norfolk)
27. Limited impact of vigorous exercise on defenses against hypoglycemia
28. Reversibility of hypoglycemia unawareness in patients with an insulinoma
29. Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction
30. Risk factors for severe hypoglycaemia in adult patients with type 1 diabetes - A prospective population based study
31. Brief twice weekly episodes of hypoglycemia reduce detection of clinical hypoglycemia in type 1 diabetes mellitus
32. Glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms
33. Blood-to-brain glucose transport, cerebral glucose metabolism and cerebral blood flow are not increased following hypoglycemia
34. Hypoglycemia-associated autonomic failure in advanced type 2 diabetes mellitus
35. Blood-barrier glucose transporter: Effects of hypo- and hyperglycemia revisited
36. Association of glycaemia with microvascular and macrovascular complications of type 2 diabetes (UKPDS 35): Prospective observational study
37. Autonomic mediation of glucagon secretion during hypoglycemia
38. Epidemiology of severe hypoglycemia in the Diabetes Control and Complications Trial
39. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
40. Hypoglycemia in the Diabetes Control and Complications Trial
41. Overview of 6 years of therapy of type II diabetes: A Progressive disease
42. A 6-year, randomized, controlled trial comparing sulfonylurea, insulin and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy
43. Intensive blood-glucose control with sulfonyl-ureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes
44. Identification of type 1 diabetic patients at increased risk for hypoglycemia during intensive therapy