United Kingdom prospective diabetes study 24: A 6-year, randomized, controlled trial comparing sulfonylurea, insulin, and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy

Annals of Internal Medicine

Volumn 128, Issue 3, 1998, Pages 165-175

  Turner, R ^a   Murchison, L ^a   Wright, A D ^a   Oakley, N ^a   Kohner, E ^a   Hayes, R ^a   Scarpello, J ^a   Hadden, D ^a   Spathis, A G ^a   Yudkin, J ^a   Greenwood, R ^a   Borthwick, L ^a   Day, J ^a   Newton, R ^a   Fox, C ^a   Paisey, R ^a   Roland, J ^a   Humphriss, D ^a   Peacock, I ^a   Boulton, A ^a   Dornan, T ^a   Burden, F ^a   Tooke, J ^a   more..

^a RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPROPAMIDE; INSULIN; METFORMIN; SULFONYLUREA;

ADULT; AGED; ARTICLE; BODY WEIGHT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET THERAPY; DOSE RESPONSE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; UNITED KINGDOM; WEIGHT GAIN;

EID: 0005169502     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-128-3-199802010-00001     Document Type: Article

References (20)

1. Guidelines for good practice in the diagnosis and treatment of non-insulin-dependent diabetes mellitus. Report of a joint working party of the British Diabetic Association, the Research Unit of the Royal College of Physicians, and the Royal College of General Practitioners. J R Coll Physicians Lond. 1993;27: 259-66.
2. Consensus statement. The pharmacological treatment of hyperglycemia in NIDDM. Diabetes Care. 1996;19(Suppl 1):S54-61.
3. UK Prospective Diabetes Study (UKPDS). VIII. Study design, progress and performance. Diabetologia. 1991;34:877-90.
4. United Kingdom Prospective Diabetes Study (UKPDS). 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. BMJ. 1995;310:83-8.
5. Phillips M, Simpson RW, Holman RR, Turner RC. A simple and rational twice daily insulin regime. Distinction between basal and meal insulin requirements. Q J Med. 1979;48:493-506.
6. UK Prospective Diabetes Study 6. Complications in newly diagnosed type 2 diabetic patients and their association with different clinical and biochemical risk factors. Diabetes Res. 1990;13:1-11.
7. UK Prospective Diabetes Study (UKPDS). XI: Biochemical risk factors in type 2 diabetic patients at diagnosis compared with age-matched normal subjects. Diabet Med. 1994;11:534-44.
8. Rudenski AS, Matthews DR, Levy JC, Turner RC. Understanding "insulin resistance": both glucose resistance and insulin resistance are required to model human diabetes. Metabolism. 1991;40:908-17.
9. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-9.
10. UK Prospective Diabetes Study. V. Characteristics of newly presenting type 2 diabetic patients: estimated insulin sensitivity and islet 4-cell function. Multicentre study. Diabet Med. 1988;5:444-8.
11. Davis MD, Hubbard LD, Trautman J, Klein R. Conference on insulin pump therapy in diabetes. Multicenter study effect on microvascular disease. Studies of retinopathy. Methodology for assessment and classification with fundus photographs. Diabetes. 1985;34(Suppl 3):42-9.
12. User's Manual. Statistical Analysis System. Version 6. Cary, NC: SAS Institute; 1990.
13. Harris MI. Undiagnosed NIDDM: clinical and public health issues. Diabetes Care. 1993;16:642-52.
14. Nabarro JD. Oral hypoglycaemic agents: the first thirty years. J R Coll Physicians Lond. 1992;26:50-5.
15. Groop L, Schalin C, Franssila-Kallunki A, Widen E, Ekstrand A, Eriksson J. Characteristics of non-insulin-dependent diabetic patients with secondary failure to oral antidiabetic therapy. Am J Med. 1989;87:183-90.
16. U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group. Diabetes. 1995;44:1249-58.
17. The University Group Diabetes Program. A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. V. Evaluation of pheniformin therapy. Diabetes. 1975;24(Suppl 1):65-184.
18. Kilo C, Miller JP, Williamson JR. The Achilles heel of the University Group Diabetes Program. JAMA. 1980;243:450-7.
19. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med. 1993;329:977-86.
20. Turner R, Stratton I, Horton V, Manley S, Zimmet P, Mackay IR, et al. UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group. Lancet. 1997;350:1288-93.