Mechanisms whereby rapid RV pacing causes LV dysfunction: Perfusion-contraction matching and NO

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 281, Issue 6 50-6, 2001, Pages

  Nikolaidis, Lazaros A ^a   Hentosz, Teresa ^a   Doverspike, Aaron ^b   Huerbin, Rhonda ^a   Stolarski, Carol ^b   Shen, You Tang ^a   Shannon, Richard P ^a  

^a ALLEGHENY GENERAL HOSPITAL   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cardiomyopathy; Hibernation; Myocardial metabolism; Nitric oxide; Stunning

Indexed keywords

FATTY ACID; GLYCOGEN; LACTIC ACID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONOTROPISM; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; FEMALE; HEART CONTRACTION; HEART DILATATION; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE METABOLISM; HEART MUSCLE OXYGEN CONSUMPTION; HEART MUSCLE PERFUSION; HEART RATE; HEART RIGHT VENTRICLE; HEART VENTRICLE PACING; HEMODYNAMICS; HUMAN; MALE; MYOCARDIAL HIBERNATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STUNNED HEART MUSCLE; TACHYCARDIA;

EID: 0035665447     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.281.6.h2270     Document Type: Article

References (73)

1. Increased inactivation of nitric oxide is involved in coronary endothelial dysfunction in heart failure
2. Function and production of NO in the coronary circulation of the conscious dog during exercise
3. Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by the generation of nitric oxide
4. The protective effects of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning
5. Nitric oxide and short-term hibernation
6. Rapid ventricular pacing in pigs: An experimental model of congestive heart failure
7. Inhibition of myocardial glucose uptake by cGMP
8. Metabolic aspects of programmed cell survival and ell death in the heart
9. Structural and metabolic correlates of the reversibility of chronic left ventricular ischemic dysfunction in humans
10. Nitric oxide in the failing human heart: A double-edged sword
11. Expression, activity and function of inducible nitric oxide synthase in the failing human heart
12. Effects of metoprolol on myocardial function and energetics in patients with non-ischemic dilated cardiomyopathy: A randomized, double-blind, placebo-controlled study
13. L-arginine reduces endothelial inflammation and myocardial stunning during ischemia/reperfusion
14. Negative inotropic effects of cytokines mediated by nitric oxide
15. Heterogeneous expression and activity of endothelial and inducible NO synthases in end-stage human heart failure
16. Chronic supraventricular tachycardia: A curable cause of congestive cardiomyopathy
17. Left ventricular dysfunction due to atrial fibrillation in patients initially believed to have idiopathic dilated cardiomyopathy
18. Enhanced basal nitric oxide production in heart failure: Another failed counter-regulatory vasodilator mechanism
19. Deletion of endothelial nitric oxide synthase exacerbates myocardial stunning in an isolated mouse heart model
20. Effects of cytokines and nitric oxide on myocardial E-C coupling
21. Inhibition of EDRF enhances myocardial stunning in conscious dogs
22. A potential role for nitric oxide in myocardial stunning
23. Alterations in energetics in patients with left ventricular dysfunction after myocardial infarction
24. Apoptosis of ventricular and atrial myocytes from pacing-induced canine heart failure
25. Hibernating myocardium
26. Endogenous nitric oxide and myocardial adaptation to ischemia
27. Endomyocardial NO synthase and left ventricular preload reserve in dilated cardiomyopathy
28. Is cardiac failure a consequence of decreased energy reserve?
29. Metabolic coronary flow regulation and exogenous NO in human coronary artery disease: Assessment by intravenous administration of nitroglycerin
30. Is the failing heart energy depleted?
31. Nitric oxide and cardiac function
32. Regulation of nitrite production in human coronary microvessels and the contribution of local kinin formation
33. Delayed enhanced NO-mediated coronary vasodilation following brief ischemia and prolonged reperfusion in conscious dogs
34. Exhaustion of Frank-Starling mechanism in conscious dogs with heart failure
35. Nitric oxide, an important regulator of perfusion-contraction matching in conscious pigs
36. Nitroprusside attenuates myocardial stunning through reduced contractile delay and time
37. Potential role of eNOS in the therapeutic control of myocardial oxygen consumption by ACE inhibitors and amlodipine
38. Tachycardia induced myocardial dysfunction
39. Transient ischemia induces regional myocardial glycogen synthase activation and glycogen synthesis in vivo
40. Glucose metabolism distal to a critical coronary stenosis in a canine model of low-flow myocardial ischemia
41. Nitric oxide synthase activity in peripheral polymorphonuclear leukocytes in patients with chronic congestive heart failure
42. Myocardial contractile response to nitric oxide and cGMP
43. Basal release of NO is decreased in the coronary circulation of patients with heart failure
44. Increased cardiac levels of nitric oxide in patients with chronic heart failure
45. Increased production of nitric oxide in coronary arteries during congestive heart failure
46. Tachycardia-induced cardiomyopathy: A reversible form of left ventricular dysfunction
47. Abnormalities in intracellular calcium regulation and contractile function in myocardium from dogs with pacing-induced heart failure
48. A perspective on the three large multi-center randomized clinical trials of coronary bypass surgery for chronic stable angina
49. Reduced nitric oxide production and altered myocardial metabolism during the decompensation of pacing-induced heart failure in the conscious dog
50. Nitric oxide controls cardiac substrate utilization in the conscious dog
51. Myocardial perfusion-contraction matching: Implications for coronary heart disease and hibernation
52. Fatty acid oxidation enzyme gene expression is down-regulated in the failing heart
53. Inducible NO synthase and TNF-alpha in myocardium in human dilated cardiomyopathy
54. Impaired regional subendocardial coronary flow reserve in conscious dogs with pacing-induced heart failure
55. Alterations in myocardial contractility in conscious dogs with dilated cardiomyopathy
56. The role of inflammatory mediators in chronic heart failure: Cytokines, nitric oxide and endothelin-1
57. Nitric oxide: An important signaling mechanism between vascular endothelium and parenchymal cells in the regulation of oxygen consumption
58. Nitric oxide donors attenuate myocardial stunning in conscious rabbits
59. Tachycardia-induced cardiomyopathy: A review of animal models and clinical studies
60. NO spares myocardial oxygen consumption through attenuation of contractile response to β-adrenergic stimulation in patients with idiopathic dilated cardiomyopathy
61. Reduced gene expression of vascular endothelial NO synthase and cyclooxygenase-1 in heart failure
62. Chronic supraventricular tachycardia causes ventricular dysfunction and subendocardial injury in swine
63. Regulation of myocardial carbohydrate metabolism under normal and ischemic conditions
64. Energy metabolism of the heart: From basic concepts to clinical applications
65. Chronic disturbances in NO production results in histochemical and subcellular alterations of the rat heart
66. Mechanisms of chronic regional post-ischemic dysfunction in humans
67. Do deficiencies of endothelial derived relaxing factor contribute to myocardial stunning?
68. Energy stores and metabolites in chronic reversibly and irreversibly dysfunctional myocardium in humans
69. Experimental congestive heart failure produced by rapid ventricular pacing in the dog: Cardiac effects
70. Alterations in left ventricular mechanics, energetics and contractile reserve in experimental heart failure
71. Role of endothelium-derived nitric oxide in the modulation of canine myocardial respiration in vitro: Implications for the development of heart failure
72. Role of myocyte NO in β-adrenergic hyporesponsiveness in heart failure
73. Pharmacodynamics of plasma nitrate/nitrite as an indication of nitric oxide formation in conscious dogs