Prothrombin 20210 G: A mutation and factor V Leiden mutation in women with a history of severe preeclampsia and (H)ELLP syndrome

Hypertension in Pregnancy

Volumn 20, Issue 3, 2001, Pages 291-298

  Van Pampus, M G ^a,b   Wolf, Hanas ^b   Koopman, Maria M W ^b   Van Den Ende, Abraham ^b   Buller, Harry R ^b   Reitsma, Pieter H ^b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Factor V Leiden mutation; Perinatal mortality; Preeclampsia; Prothrombin 20210 G A mutation; Thromboembolism

Indexed keywords

BLOOD CLOTTING FACTOR 5; LIVER ENZYME; PROTHROMBIN;

ADULT; ARTICLE; FEMALE; GENE MUTATION; GENETIC RISK; HELLP SYNDROME; HUMAN; MAJOR CLINICAL STUDY; PERINATAL MORTALITY; PREECLAMPSIA; PREVALENCE; PUERPERIUM; RISK; RISK FACTOR; THROMBOEMBOLISM; VEIN THROMBOSIS;

ADULT; ARGININE; FACTOR V; FEMALE; GLUTAMINE; HELLP SYNDROME; HUMANS; POINT MUTATION; PRE-ECLAMPSIA; PREGNANCY; PROTHROMBIN;

EID: 0035663185     PISSN: 10641955     EISSN: None     Source Type: Journal    
DOI: 10.1081/PRG-100107831     Document Type: Article

References (22)

1. Underlying disorders associated with severe early-onset preeclampsia
2. Increased fetal loss in women with heritable thrombophilia
3. High prevalence of hemostatic abnormalities in women with a history of severe preeclampsia
4. Factor V Leiden and other coagulation factor mutations affecting thrombotic risk
5. The prothrombin gene 3′-untranslated region mutation is frequently associated with factor V Leiden in thrombophilic patients and shows ethnic-specific variation in allele frequency
6. The prothrombin 20210 A Allele is frequently coinherited in young carriers of the factor V Arg 506 to Gln mutation with venous thrombophilia
7. Activated protein C resistance can be associated with recurrent fetal loss
8. Activated protein C resistance and adverse pregnancy outcome
9. The factor V Leiden mutation may predispose women to severe preeclampsia
10. Fetal carriers of the factor V Leiden mutation are prone to miscarriage and placental infarction
11. Factor V Leiden is associated with repeated and recurrent unexplained fetal losses
12. Increased risk for fetal loss in carriers of the factor V Leiden mutation
13. Increased frequency of genetic thrombophilia in women with complications of pregnancy
14. Case-control study of the frequency of thrombophilic disorders in couples with late foetal loss and no thrombotic antecedent - The Nimes Obstetricians and Haematologists Study5 (NOHA5)
15. Preeclampsia and genetic risk factors for thrombosis: A case-control study
16. The HELLP syndrome (hemolysis, elevated liver enzymes and low platelets): Much ado about nothing?
17. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in Venous thrombosis
18. Association of idiopathic Venous thromboembolism with single point-mutation at Arg506 of Factor V
19. A common prothrombin variant (20210 G to A) increases the risk of myocardial infarction in young women
20. Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women
21. Interaction of coagulation defects and cardiovascular risk factors: Increased risk of myocardial infarction associated with factor V Leiden or prothrombin 20210A
22. Prevalence of the prothrombin gene variant 20210 G→A among patients with myocardial infarction