Activated protein C resistance can be associated with recurrent fetal loss

British Journal of Haematology

Volumn 97, Issue 3, 1997, Pages 551-554

  Brenner, Benjamin ^a,c   Mandel, Hanna ^a   Lanir, Naomi ^a   Younis, Johnny ^b   Rothbart, Haim ^b   Ohel, Gonen ^b   Blumenfeld, Zeev ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b Poriya Hospital   (Israel)

^c RAMBAM MEDICAL CENTER   (Israel)

Author keywords

factor V Leiden; placental thrombosis; pregnancy; protein C resistance

Indexed keywords

PROTEIN C;

ADULT; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CLINICAL ARTICLE; ENZYME ACTIVATION; FEMALE; FETUS BLOOD; FETUS DEATH; FETUS WASTAGE; GENE MUTATION; GENE TARGETING; HUMAN; INTRAUTERINE GROWTH RETARDATION; PREECLAMPSIA; PRIORITY JOURNAL; RECURRENT ABORTION; THROMBOSIS;

EID: 0031004309     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.882901.x     Document Type: Article

References (13)

1. Brenner, B., Lanir, N. & Thaler, I. (1996) HELLP syndrome associated with factor V R 506Q mutation. British Journal of Haematology, 92, 999-1001.
2. Hellgren, M., Svensson, P.J. & Dahlback, B. (1995) Resistance to activated protein C as a basis for venous thromboembolism associated with pregnancy and oral contraceptives. American Journal of Obstetrics and Gynecology, 173, 210-213.
3. Infante-Rivard, C., David, M., Gauthier, R. & Riverd, G.E. (1991) Lupus anticoagulants, anticardiolipin antibodies and fetal loss. New England Journal of Medicine, 325, 1063-1066.
4. Italian Registry of Antiphospholipid Antibodies (IR-APA) (1993) Thrombosis and thrombocytopenia in antiphospholipid syndrome (idiopathic and secondary to SLE): first report from the Italian Registry. Haematologica, 78, 313-318.
5. Mandel, H., Brenner, B., Berant, M., Rosenberg, N., Lanir, N., Jakobs, C., Fowler, B. & Seligsohn, U. (1996) Coexistence of hyperhomo-cysteinemia and factor V Leiden mutation: impact on expression of thrombosis. New England Journal of Medicine, 334, 763-768.
6. Many A., Pauzner, R., Carp, H., Langeritz, P. & Martinowitz, U. (1992) Treatment of patients with antiphospholipid antibodies during pregnancy. American Journal of Reproductive Immunology, 28, 216-218.
7. Mathonnet, F., de Mazancourt, P., Bastenaire, B., Rorot, M., Benattar, N., Reufe, S., Borg, J.I. & Giudicelli, Y. (1996) Activated protein C sensitivity ratio in pregnant women at delivery. British Journal of Haematology, 92, 244-246.
8. Out, H.J., Kooijman, C.D., Bruise, H.W. & Derksen, R. (1991) Histopathological findings in placentae from patients with intra-uterine fetal death and anti-phospholipid antibodies. European Journal of Obstetrics. Gynaecology and Reproductive Biology, 41, 179-184.
9. Preston, F.E., Rosendaal, F.R., Walker, I.D., Briët, E., Berntorp, E., Conard, J., Fontcuberta, J., Makris, M., Mariani, G., Noteboom, W., Pabinger, I., Legnani, C., Scharrer, I., Schulman, S. & van der Meer, F.J.M. (1996) Increased fetal loss in women with heritable thrombophilia. Lancet, 348, 913-916.
10. Rai, R., Regan, L., Hadley, E., Dave, M. & Cohen, H. (1996) Second trimester pregnancy loss is associated with activated protein C resistance. British Journal of Haematology, 92, 489-490.
11. Sanson, B.J., Friederich, P.W., Simioni, P., Zanardi, S., Huisman, M.V., Girolami, A., ten Cate, J.W. & Prins, M.H. (1996) The risk of abortion and stillbirth in antithrombin-protein C- and protein S-deficient women. Thrombosis and Haemostasis, 75, 387-388.
12. Schleider, M.A., Nachman, R.L., Jaffe, E.A. & Coleman, M. (1976) A clinical study of the lupus anticoagulant. Blood, 28, 499-509.
13. Thiagarajan, P., Pengo, V. & Shapiro, S.S. (1986) The use of the dilute Russell viper venom time for the diagnosis of lupus anticoagulant. Blood, 68, 869-874.