Structure of histone deacetylases: Insights into substrate recognition and catalysis

Structure

Volumn 9, Issue 12, 2001, Pages 1127-1133

  Marmorstein, Ronen ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; ISOENZYME;

CATALYSIS; CHICKEN; DEACETYLATION; DROSOPHILA; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE REPRESSION; GENE SILENCING; GENETIC PROCEDURES; HUMAN; MAIZE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION; YEAST;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; HISTONE DEACETYLASES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

GALLUS GALLUS; ZEA MAYS;

EID: 0035662888     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(01)00690-6     Document Type: Review

References (44)

1. Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis
2. Tetrahymena histone acetyltransferase A: A homolog of yeast Gcn5p linking histone acetylation to gene activation
3. Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription
4. Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains
5. The p300/CBP family: Integrating signals with transcription factors and chromatin
6. The CBP co-activator is a histone acetyltransferase
7. The TAF(II)250 subunit of TFIID has histone acetyltransferase activity
8. Steroid receptor coactivator-1 is a histone acetyltransferase
9. Histone deacetylases, transcriptional control, and cancer
10. A mammalian histone deacetylase related to the yeast transcription regulator Rpd3p
11. The human histone deacetylase family
12. Histone acetylation: Plants and fungi as model systems for the investigation of histone deacetylases
13. Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia
14. Role of the histone deacetylase complex in acute promyelocytic leukaemia
15. Transcriptional control at regulatory checkpoints by histone deacetylases: Molecular connections between cancer and chromatin
16. Inhibition of histone deacetylases: A new strategy to target epigenetic modifications for anticancer treatment
17. Histone deacetylases: Silencers for hire
18. Sin meets NuRD and other tails of repression
19. HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex
20. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription
21. Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization
22. Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras
23. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
24. Active maintenance of mHDA2/mHDAC6 histone-deacetylase in the cytoplasm
25. HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor
26. Three proteins define a class of human histone deacetylases related to yeast Hda1p
27. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
28. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
29. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
30. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
31. A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast
32. Structure of the histone deacetylase SIRT2
33. Crystal structure of a SIR2 homolog-NAD complex
34. Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
35. The charge relay system in chymotrypsin and chymotrypsinogen
36. Structure of a unique binuclear manganese cluster in arginase
37. A role for histone deacetylase activity in HDAC1-mediated transcriptional repression
38. Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo
39. The nicotinamide dinucleotide binding motif: A comparison of nucleotide binding proteins
40. RING domains: Master builders of molecular scaffolds?
41. The N-terminal domain of TFIIB from Pyrococcus furiosus forms a zinc ribbon
42. Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose
43. Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product
44. The conserved core of a human SIR2 homologue functions in yeast silencing