Nitric oxide and cGMP protein kinase activity in aged ventricular myocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 281, Issue 6 50-6, 2001, Pages

  Zhang, Qihang ^a   Molino, Bruno ^a   Yan, L I N ^a   Haim, Todd ^a   Vaks, Yakir ^a   Scholz, Peter M ^a   Weiss, Harvey R ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Aging; Cardiac myocytes; Myocyte function; Rabbit

Indexed keywords

CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; KT 5823; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; NITRIC OXIDE DONOR; PROTEIN KINASE INHIBITOR;

AGED; AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CELL FUNCTION; ELECTROPHORESIS; ENZYME ACTIVITY; HEART MUSCLE CELL; HEART VENTRICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RABBIT; SIGNAL TRANSDUCTION;

EID: 0035658402     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.281.6.h2304     Document Type: Article

References (33)

1. Aging is associated with reduced basal and stimulated release of nitric oxide by the coronary endothelium
2. Effects of age on mechanical and structural properties of myocardium of Fischer 344 rats
3. Inverse regulation of endothelin-1 and nitric oxide metabolites in tissue with aging: Implications for the age-dependent increase of cardiorenal disease
4. Nitric oxide attenuates cardiac myocyte contraction
5. Human SERCA2a levels correlate inversely with age in senescent human myocardium
6. 2+ influx
7. Aging selectively decreases oxidative capacity in rat heart interfibrillar mitochondria
8. Aging-dependent depression in the kinetics of force development in rat skinned myocardium
9. Morphological and contractile characteristics of rat cardiac myocytes from maturation to senescence
10. Cyclic GMP reduces ventricular myocyte stunning after simulated ischemia-reperfusion
11. Exogenous nitric oxide reduces oxygen consumption of isolated ventricular myocytes less than other forms of guanylate cyclase stimulation
12. Role of nitric oxide in the pathogenesis of chronic pulmonary hypertension
13. Effects of cyclopentyladenosine on isoproterenol response in adult and senescent cardiac tissue from Fischer 344 rats
14. Store-operated calcium entry in vascular endothelial cells is inhibited by cGMP via a protein kinase G-dependent mechanism
15. Age-related changes in activities of mitochondrial electron transport complexes in various tissues of the mouse
16. Cardiovascular regulatory mechanisms in advanced age
17. 2+ currents in rat ventricular myocytes
18. Signal transduction by cGMP in heart
19. Age-related changes in vascular responses
20. 2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes
21. 2+ current. Involvement of cGMP-inhibited and cGMP-stimulated phosphodiesterases through guanylate cyclase activation
22. 2+-ATPase by cGMP-dependent protein kinase
23. Influence of age on contractile response to insulin-like growth factor 1 in ventricular myocytes from spontaneously hypertensive rats
24. Influence of age on inotropic response to insulin and insulin-like growth factor I in spontaneously hypertensive rats: Role of nitric oxide
25. Downregulation of soluble guanylyl cyclase in young and aging spontaneously hypertensive rats
26. Regulation of slow calcium channels of myocardial cells and vascular smooth muscle cells by cyclic nucleotides and phosphorylation
27. Redox signaling: Nitrosylation and related target interactions of nitric oxide
28. Cyclic GMP protein kinase mediates negative metabolic and functional effects of cyclic GMP in control and hypertrophied rabbit cardiac myocytes
29. Age-associated changes in nitric oxide metabolites nitrite and nitrate
30. Effects of aging on single cardiac myocyte function in Fischer 344 x Brown Norway rats
31. Cyclic GMP and cyclic AMP induced changes in control and hypertrophic cardiac myocyte function interact through cyclic GMP affected cyclic-AMP phosphodiesterases
32. Release of nitric oxide from endothelial cells stimulated by YC-1, an activator of soluble guanylyl cyclase
33. Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation