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PID: 10719971, COI: 1:STN:280:DC%2BD3c7ot1yqsg%3D%3D, The GABA-B agonist, baclofen, produces powerful antinociception diverse animal models of acute and chronic pain. Although intrathecal baclofen is an effective treatment for spasticity humans, it is a poor analgesic when used for the management of chronic pain. This study demonstrates that intrathecal baclofen produces analgesia patients with neuropathic pain and suggests a renewed place for this class of analgesic the clinical setting
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Nitescu P, Dahm P, Appelgren L, Curelaru I: Continuous infusion of opioid and bupivacaine by externalized intrathecal catheters in long-term treatment of “refractory” nonmalignant pain. Clin J Pain 1998, 14:17–28. DOI: 10.1097/00002508-199803000-00004
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PID: 9303259, COI: 1:STN:280:DyaK2svkvV2gtw%3D%3D, Omega-conotoxins are N-type voltage-sensitive calcium channel antagonists that produce antinociception animals and analgesia humans after spinal injection. this study, ziconotide (SNX-111) was administered by spinal infusion to a patient with brachial plexus avulsion. Severe side effects such as nystagmus and dizziness were dose-dependent and diminished by gradual dose reduction. This study describes the clinical use of this novel class of anti-hyperalgesic and anti-allodynic agents for the treatment of chronic neuropathic pain humans
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Brose WG, Gutlove DP, Luther RR, et al.: Use of intrathecal SNX-111, a novel, N-type, voltage-sensitive, calcium channel blocker, in the management of intractable brachial plexus avulsion pain. Clin J Pain 1997, 13:256–259. Omega-conotoxins are N-type voltage-sensitive calcium channel antagonists that produce antinociception in animals and analgesia in humans after spinal injection. In this study, ziconotide (SNX-111) was administered by spinal infusion to a patient with brachial plexus avulsion. Severe side effects such as nystagmus and dizziness were dose-dependent and diminished by gradual dose reduction. This study describes the clinical use of this novel class of anti-hyperalgesic and anti-allodynic agents for the treatment of chronic neuropathic pain in humans. DOI: 10.1097/00002508-199709000-00012
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PID: 1484720, COI: 1:STN:280:DyaK3s7jtlKnsg%3D%3D
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Kristensen JD, Svensson B, Gordh T Jr: The NMDA-receptor antagonist CPP abolishes neurogenic “wind-up pain” after intrathecal administration in humans. Pain 1992, 51:249–253. DOI: 10.1016/0304-3959(92)90266-E
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Penn RD, Paice JA, Kroin JS: Octreotide: a potent new non-opiate analgesic for intrathecal infusion. Pain 1992, 49:13–19. DOI: 10.1016/0304-3959(92)90182-B
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Hassenbusch SJ, Portenoy RK: Current practices in intraspinal therapy—a survey of clinical trends and decision making. J Pain Symptom Manage 2000, 20:S4-S11. The investigators used an Internet-based survey to characterize the practice patterns of pain practitioners who use intrathecal therapy for the management of chronic pain. The survey demonstrated that practice patterns vary widely among practitioners who use spinal infusion therapy. This report highlights the need for improved research outcomes that can be used as a guideline for the use of this mode of therapy. DOI: 10.1016/S0885-3924(00)00203-7
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Behavioral and histopathologic effects following intrathecal administration of butorphanol, sufentanil, and nalbuphine in sheep
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Rawal N, Nuutinen L, Raj PP, et al.: Behavioral and histopathologic effects following intrathecal administration of butorphanol, sufentanil, and nalbuphine in sheep. Anesthesiology 1992, 77:605–607. DOI: 10.1097/00000542-199209000-00039
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Anesthesiology
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Rawal, N.1
Nuutinen, L.2
Raj, P.P.3
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40
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0027103035
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Intrathecal baclofen suppresses central pain in patients with spinal lesions. A pilot study
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PID: 1493344, COI: 1:STN:280:DyaK3s7ltlSrtw%3D%3D
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Herman RM, D’Luzansky SC, Ippolito R: Intrathecal baclofen suppresses central pain in patients with spinal lesions. A pilot study. Clin J Pain 1992, 8:338–345. DOI: 10.1097/00002508-199212000-00008
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Herman, R.M.1
D’Luzansky, S.C.2
Ippolito, R.3
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41
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0027524134
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Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study
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PID: 8421205, COI: 1:STN:280:DyaK3s7jt1Gltg%3D%3D
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Coffey JR, Cahill D, Steers W, et al.: Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study. J Neurosurg 1993, 78:226–232. DOI: 10.3171/jns.1993.78.2.0226
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J Neurosurg
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Coffey, J.R.1
Cahill, D.2
Steers, W.3
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42
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0029810150
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Intrathecal clonidine and baclofen in the management of spasticity and neuropathic pain following spinal cord injury: a case study
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PID: 8702379, COI: 1:STN:280:DyaK28zit1ejuw%3D%3D
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Middleton JW, Siddall PJ, Walker S, et al.: Intrathecal clonidine and baclofen in the management of spasticity and neuropathic pain following spinal cord injury: a case study. Arch Phys Med Rehabil 1996, 77:824–826. DOI: 10.1016/S0003-9993(96)90264-6
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Middleton, J.W.1
Siddall, P.J.2
Walker, S.3
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43
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0026569871
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Neuropathologic findings after long-term intrathecal infusion of morphine and bupivacaine for pain treatment in cancer patients
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PID: 1736693, COI: 1:STN:280:DyaK387ktlaqtQ%3D%3D
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Sjoberg M, Karlsson PA, Nordborg C, et al.: Neuropathologic findings after long-term intrathecal infusion of morphine and bupivacaine for pain treatment in cancer patients. Anesthesiology 1992, 76:173–186. DOI: 10.1097/00000542-199202000-00004
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Sjoberg, M.1
Karlsson, P.A.2
Nordborg, C.3
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44
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0021934434
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Intrathecal somatostatin in terminally ill patients. A report of two cases
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PID: 2865713, COI: 1:STN:280:DyaL28%2FktFCmsw%3D%3D
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Meynadier J, Chrubasik J, Dubar M, Wunsch E: Intrathecal somatostatin in terminally ill patients. A report of two cases. Pain 1985, 23:9–12. DOI: 10.1016/0304-3959(85)90224-6
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Meynadier, J.1
Chrubasik, J.2
Dubar, M.3
Wunsch, E.4
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45
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0030220597
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Analgesic effect of subarachnoid neostigmine in two patients with cancer pain
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PID: 8880864, COI: 1:CAS:528:DyaK28XlvFOis7c%3D
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Klamt JG, Dos Reis MP, Barbieri NJ, Prado WA: Analgesic effect of subarachnoid neostigmine in two patients with cancer pain. Pain 1996, 66:389–391. DOI: 10.1016/0304-3959(96)03045-X
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Pain
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Klamt, J.G.1
Dos, R.M.P.2
Barbieri, N.J.3
Prado, W.A.4
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46
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15144343497
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Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors
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PID: 9417028, COI: 1:CAS:528:DyaK1cXjsFOgtg%3D%3D, ABT-594 is a neuronal nicotinic acetylcholine receptor ligand that produces powerful antinociception animal models of acute thermal, persistent chemical, and neuropathic pain states. Unlike morphine, repeated treatment with ABT-594 was not associated with withdrawal or physical dependence. These favorable properties suggest a potential role for this class of analgesic chronic infusion paradigms humans
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Bannon AW, Decker MW, Holladay MW, et al.: Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors. Science 1998, 279:77–81. ABT-594 is a neuronal nicotinic acetylcholine receptor ligand that produces powerful antinociception in animal models of acute thermal, persistent chemical, and neuropathic pain states. Unlike morphine, repeated treatment with ABT-594 was not associated with withdrawal or physical dependence. These favorable properties suggest a potential role for this class of analgesic in chronic infusion paradigms in humans. DOI: 10.1126/science.279.5347.77
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(1998)
Science
, vol.279
, pp. 77-81
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Bannon, A.W.1
Decker, M.W.2
Holladay, M.W.3
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47
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0034023364
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P2X receptors in sensory neurones
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PID: 10823099, COI: 1:CAS:528:DC%2BD3cXivFWkurc%3D, P2X3 receptors are expressed selectively on small-diameter sensory-specific afferent neurons. P2X3 receptors are downregulated after neuropathic injury animals and may be regulated by certain neurotrophic factors. As such, this subclass of purinergic receptors represents a novel substrate for the development of putative analgesics
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Burnstock G: P2X receptors in sensory neurones. Br J Anaesth 2000, 84:476–488. P2X3 receptors are expressed selectively on small-diameter sensory-specific afferent neurons. P2X3 receptors are downregulated after neuropathic injury in animals and may be regulated by certain neurotrophic factors. As such, this subclass of purinergic receptors represents a novel substrate for the development of putative analgesics.
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(2000)
Br J Anaesth
, vol.84
, pp. 476-488
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Burnstock, G.1
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48
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0032746351
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The molecular pathophysiology of pain: abnormal expression of sodium channel genes and its contributions to hyperexcitability of primary sensory neurons
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PID: 10491982
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Waxman SG: The molecular pathophysiology of pain: abnormal expression of sodium channel genes and its contributions to hyperexcitability of primary sensory neurons. Pain 1999, 6:S133-S140. DOI: 10.1016/S0304-3959(99)00147-5
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(1999)
Pain
, vol.6
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Waxman, S.G.1
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49
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0034237197
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Human chromaffin cell graft into the CSF for cancer pain management: a prospective phase II clinical study
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PID: 10863042, COI: 1:STN:280:DC%2BD3cvjtFSgtQ%3D%3D
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Lazorthes Y, Sagen J, Sallerin B, et al.: Human chromaffin cell graft into the CSF for cancer pain management: a prospective phase II clinical study. Pain 2000, 87:19–32. DOI: 10.1016/S0304-3959(00)00263-3
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(2000)
Pain
, vol.87
, pp. 19-32
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Lazorthes, Y.1
Sagen, J.2
Sallerin, B.3
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50
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0032738128
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Intrathecal drug therapy for chronic pain: from basic science to clinical practice
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PID: 10598634, COI: 1:STN:280:DC%2BD3c%2FmsFKqsQ%3D%3D
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Dougherty PM, Staats PS: Intrathecal drug therapy for chronic pain: from basic science to clinical practice. Anesthesiology 1999, 91:1891–1918. DOI: 10.1097/00000542-199912000-00044
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(1999)
Anesthesiology
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, pp. 1891-1918
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Dougherty, P.M.1
Staats, P.S.2
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51
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0030764290
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Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor
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PID: 9323204, COI: 1:CAS:528:DyaK2sXms1Cqur0%3D, Rexed lamina I of the spinal cord dorsal horn is a primary site for the integration and relaying of sensory information. Neurons these superficial laminae express the substance P receptor, which transmits noxious input to higher brain structures. this study, a substance P receptor, cytotoxin, was injected into the subarachnoid space, and this toxin markedly attenuated behavioral responses to noxious stimuli. These results demonstrate the potential role of neuronal cellular toxins as selective targets for the treatment of intractable pain
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Mantyh PW, Rogers SD, Honore P, et al.: Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor. Science 1997, 278:275–279. Rexed lamina I of the spinal cord dorsal horn is a primary site for the integration and relaying of sensory information. Neurons in these superficial laminae express the substance P receptor, which transmits noxious input to higher brain structures. In this study, a substance P receptor, cytotoxin, was injected into the subarachnoid space, and this toxin markedly attenuated behavioral responses to noxious stimuli. These results demonstrate the potential role of neuronal cellular toxins as selective targets for the treatment of intractable pain. DOI: 10.1126/science.278.5336.275
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(1997)
Science
, vol.278
, pp. 275-279
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Mantyh, P.W.1
Rogers, S.D.2
Honore, P.3
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52
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0033832189
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Evidence-based review of the literature on intrathecal delivery of pain medication
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PID: 10989255, COI: 1:STN:280:DC%2BD3cvktlKmsw%3D%3D
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Bennett G, Serafini M, Burchiel K, et al.: Evidence-based review of the literature on intrathecal delivery of pain medication. J Pain Symptom Manage 2000, 20:S12-S36. DOI: 10.1016/S0885-3924(00)00204-9
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(2000)
J Pain Symptom Manage
, vol.20
, pp. S12-S36
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Bennett, G.1
Serafini, M.2
Burchiel, K.3
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