Analgesic and adverse effects of a low dose of intrathecally administered hyperbaric neostigmine alone or combined with morphine in patients submitted to spinal anaesthesia: Pilot studies

Anaesthesia

Volumn 54, Issue 1, 1999, Pages 27-31

  Klamt, J G ^a   Garcia, L V ^a   Prado, W A ^b  

^a Discipline of Anaesthesiology   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Anticholinesterases, neostigmine; Pain, postoperative pain

Indexed keywords

CHOLINESTERASE INHIBITOR; MORPHINE; NEOSTIGMINE; OPIATE;

ANALGESIA; ANXIETY; ARTICLE; CESAREAN SECTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FECES INCONTINENCE; HUMAN; INTERMITTENT CLAUDICATION; INTRATHECAL DRUG ADMINISTRATION; NAUSEA; ORTHOPEDIC SURGERY; POSTOPERATIVE PAIN; PRURITUS; SOMNOLENCE; SPINAL ANESTHESIA; VOMITING;

ANALGESIA, OBSTETRICAL; ANALGESICS, OPIOID; ANESTHESIA, SPINAL; CESAREAN SECTION; CHOLINESTERASE INHIBITORS; DRUG COMBINATIONS; FEMALE; HUMANS; INJECTIONS, SPINAL; MORPHINE; NEOSTIGMINE; ORTHOPEDIC PROCEDURES; PAIN, POSTOPERATIVE; PILOT PROJECTS; POSTOPERATIVE NAUSEA AND VOMITING; PREGNANCY;

EID: 0032949012     PISSN: 00032409     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2044.1999.00634.x     Document Type: Article

References (17)

1. Green PG, Kitchen I. Antinociception opioids and the cholinergic system. Progressive Neurobiology 1986; 26: 119-46.
2. Klamt JG, Shullitel A, Garcia LV, Frado WA. Postoperative analgesic effect of intrathecal neostigmine and its influence on spinal anaesthesia. Anaesthesia 1997; 52: 547-51.
3. Lauretti GR, Reis MP, Prado WA, Klamt JG. Dose-response study of intrathecal morphine versus intrathecal neostigmine, their combination, or placebo for postoperative analgesia in patients undergoing anterior and posterior vaginoplasty. Anesthesia and Analgesia 1996; 82: 1182-7.
4. Hood DD, Eisenach J, Tuttle R. Phase I safety assessment ot intrathecal neostigmine methylsulfate in humans. Anesthesiology 1985; 82: 231-43.
5. Lauretti GR, Reis MP. Subarachnoid neostigmine does not affect blood pressure or heart rate during bupivacaine spinal anesthesia. Regional Anesthesia 1996; 21: 586-91.
6. Lauretti GR, Reis MP. Postoperative analgesia and antiemetic efficacy after subarachnoid neostigmine in orthopedic surgery. Regional Anesthesia 1997; 22: 337-12.
7. Klamt JG, Reis MP, Barbieri Neto J, Prado WA. Analgesic effect of subarachnoid neostigmine in two patients with cancer pain. Pain 1996; 66: 389-91.
8. Clark PM. Intrathecal neostigmine. Anaesthesia 1997; 52: 1018.
9. Pan PM, Mok MS. Efficacy or intrathecal neostigmine for relief of post Caesarean pain. Anesthesiology 1995; 83: A786.
10. McDonald JS, Mandalfino DA. Subarachnoid block. In: Bonica JJ, McDonald JS, eds. Principles and Practice of Obstetric Analgesia and Anesthesia. Williams and Wilkins, 1995; 471-96.
11. Abboud TK, Shnider SM, Hailey PA, et al. Intrathecal administration of hyperbaric morphine for the relief of pain in labour. British Journal of Anaesthesia 1984; 56: 1351-6.
12. Gage PG, D'Angelo R, Miller R, Eisenach JC. Does dextrose affect analgesia or side effects ot intrathecal sufentanil. Anesthesia and Analgesia 1977; 85: 826-30.
13. Lauretti GR, Lima IC. The effects of intrathecal neostigmine on somatic and visceral pain: improvement by association with a peripheral anticholinergic. Anesthesia and Analgesia 1996; 82: 617-20.
14. Abouleish E. Apnoea associated with the intrathecal administration of morphine in obstetrics. British Journal of Anaesthesia 1988; 60: 592-4.
15. Weinstock M, Davidson JT, Robin AJ, Sheiden A. Effect ot physostigmine on morphine-induced postoperative pain and somnolence. British Journal of Anaesthesia 1982; 54: 4229-43.
16. Snir-Mor I, Weinstock M, Davidson JT, Bahar M. Physostigmine antagonises morphine-induced respiratory depression in human subjects. Anesthesiology 1983; 59: 6-9.
17. Willette RN, Doorley BM, Sapru HN. Activation of cholinergic mechanisms in the medulla oblongata reverse intravenous opioid-induced depression. Journal of Pharmacology and Experimental Therapeutics 1987; 240: 352-8.