RUNX genes, neoplasia, and cleidocranial dysplasia

American Journal of Medical Genetics

Volumn 104, Issue 3, 2001, Pages 185-188

  Cohen Jr , M Michael ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ALTERNATIVE RNA SPLICING; AMINO TERMINAL SEQUENCE; CHROMOSOME MAP; CLEIDOCRANIAL DYSPLASIA; EDITORIAL; GENE MUTATION; HUMAN; NEOPLASM; OSTEOBLAST; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; STEM CELL;

ANIMALS; CLEIDOCRANIAL DYSPLASIA; CORE BINDING FACTOR ALPHA 2 SUBUNIT; CORE BINDING FACTOR ALPHA 3 SUBUNIT; CORE BINDING FACTOR ALPHA SUBUNITS; DNA-BINDING PROTEINS; HUMANS; NEOPLASM PROTEINS; NEOPLASMS; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION FACTORS;

EID: 0035576269     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajmg.10064     Document Type: Editorial

References (47)

1. Inactivation of Runx3 in stomach cancer cell lines
2. Runt homology domain proteins in osteoblast differentiation: AML-3/Cbfa1 is a major component of a bone specific complex
3. Cloning of 2.5 kb murine bone sialoprotein promoter fragment and functional analysis of putative Osf2 binding sites
4. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
5. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
6. Cbfa1 is a positive regulatory factor in chondrocyte maturation
7. Interaction and functional cooperation of PEBP2/CBF with Smads: Synergistic induction of the immunoglobulin germline Cα promoter
8. Maturational disturbance of chondrocytes in Cbfa1-deficient mice
9. Molecular basis of tissue-specific gene expression mediated by the Runt domain transcription factor PEBP2/CBF
10. Phenotypes of Runx3 knock-out mouse
11. The runt domain transcription factor, PEBP2/CBF, and its involvement in human leukemia
12. Somatic development in cleidocranial dysplasia
13. Development of the dentition in cleidocranial dysplasia
14. Development of the skull in infants with cleidocranial dysplasia
15. Craniofacial growth in cleidocranial dysplasia. A roentgencephalometric study
16. Collagenase-3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation
17. Cbfa1 in bone development
18. Targeted disruption of cbfal results in a complete lack of bone formation owing to maturational arrest of osteoblasts
19. Anomalies of craniofacial skeleton and teeth in cleidocranial dysplasia
20. Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/ CBFA1
21. Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression on osteoblastic osteosarcoma ROS17/2.8 cells and primary rat calvaria cells
22. Analysis of the tooth development in Cbfa1-deficient mice
23. Cleidocranial dysplasia: Clinical and molecular genetics
24. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
25. In vivo and in vitro analysis of CBFA1/RUNX2 oncogenic functions
26. Hematopoietic lineage maturation inherent in the endothelium
27. PEBP2/PEA2 represents a new family of transcription factor homologous to the products of the Drosophila runt and the human AML1 gene
28. Hematopoietic rescue of AMLI-deficient mouse embryonic stem cells by expressing transcriptionally active PEBP2αB1 (mouse AML1b)
29. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEB2αB gene associated with myeloblastic leukemias
30. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
31. Differential expression patterns of Runx2 isoforms in cranial suture morphogenesis
32. Upstream and downstream of RUNX1
33. Mutation analysis of core binding factor A1 in patients with cleidocranial dysplasia
34. The missing bone
35. Hemizygous deletion and reduced expression of RUNX3 in primary gastric cancers
36. Transcriptional regulation of osteopontin gene in vivo by Pebp2αA/Cbfa1 and Ets1 in the skeletal tissue
37. Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase. A-dependent transactivation of core binding factor alpha1
38. Haploinsufficiency of CBFA2 causes familial thromboytopenia with propensity to develop acute myelogenous leukemia
39. Proviral insertions induce the expression of bone-specific isoforms of Pebp2αA (CBFA1): Evidence for a new myc collaborating oncogene
40. Rescue of AMLl-deficient embryos from death during midgestation by the transgenic expression of AML1 under the regulatory influence of the GATA-1 gene
41. A role for hematopoietic stem cells in promoting angiogenesis
42. Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfa
43. The osteoblast-specific transcription factor Cbfa1 regulates the expression of osteoprotegerin (OPG), a potent inhibitor of osteoclast differentiation and function
44. Runt domains take the lead in hematopoiesis and osteogenesis
45. Genomic structure and isoform expression of mouse, rat and human Cbfa1/Osf2 transcription factor
46. Cbfa1 isoform over-expression upregulates osteocalcin gene expression in nonosteoblastic and pre-osteoblastic cells
47. A RUNX2/PEBP2αA/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia