Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2

Journal of Immunology

Volumn 167, Issue 11, 2001, Pages 6615-6622

  Miike, S ^a   McWilliam, A S ^a   Kita, H ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE ACTIVATED RECEPTOR 2; TRYPSIN;

AMINO TERMINAL SEQUENCE; ARTICLE; ENZYME ACTIVITY; EOSINOPHIL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; INFLAMMATORY CELL; LAMINA PROPRIA; LIGAND BINDING; MEDIATOR RELEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; T LYMPHOCYTE ACTIVATION;

EID: 0035575784     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.11.6615     Document Type: Article

References (45)

1. Eosinophil-associated diseases
2. Biology of eosinophils
3. Increased biosynthesis of platelet-activating factor in activated human eosinophils
4. Stimulus-dependent differences in superoxide anion generation by normal human eosinophils and neutrophils
5. IgA-induced eosinophil degranulation
6. Eosinophilic inflammation in asthma
7. Platelet activating factor induces eosinophil peroxidase release from purified human eosinophils
8. Cytokines directly induce degranulation and superoxide production from human eosinophils
9. Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils
10. Purification and characterization of a fibrinogenolytic serine proteinase from Asperigillus fumigatus culture filtrate
11. The isolation and characterization of a novel collagenolytic serine protease allergen (Der p 9) from the dust mite Dermatophagoides pteronyssinus
12. Trypsin-like protease of mites: Purification and characterization of trypsin-like protease from mite faecal extract Dermatophagoides farinae: Relationship between trypsin-like protease and Derf III
13. Substrate preference profiles of proteases released by allergenic pollens
14. Tryptase: A clinical indicator of mast cell-dependent events
15. Tryptase from human pulmonary mast cells: Purification and characterization
16. Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway
17. Protease-activated G protein-coupled receptors on human platelets and endothelial cells
18. 2+ mobilization
19. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
20. Molecular cloning of a potential proteinase activated receptor
21. Protease-activated receptor 3 is a second thrombin receptor in humans
22. Cloning and characterization of human protease-activated receptor 4
23. A dual thrombin receptor system for platelet activation
24. Thrombin signalling and protease-activated receptors
25. Proteinase-activated receptors: Novel mechanisms of signaling by serine proteases
26. Protease-activated receptors: Sentries for inflammation?
27. Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart
28. A protective role for protease-activated receptors in the airways
29. Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation
30. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
31. Tethered ligand agonist peptides: Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function
32. Proteinase-activated receptor-2: Expression by human neutrophils
33. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
34. 2+ mobilization in human T cell lines through interaction with different protease-activated receptors
35. Endothelial cell thrombin receptors and PAR-2: Two protease-activated receptors located in a single cellular environment
36. Intestinal type 2 proteinase-activated receptors: Expression in opioid-sensitive secretomotor neural circuits that mediate epithelial ion transport
37. An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils
38. CD11b/CD18 (Mac-I) is required for degranulation of human eosinophils induced by human recombinant granulocyte-macrophage colony-stimulating factor and platelet-activating factor
39. A microtiter plate assay for the characterization of serine proteases by their esterase activity
40. Protease-activated receptors in inflammation, neuronal signaling and pain
41. Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases
42. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2
43. How the protease thrombin talks to cells
44. Human lung tryptase: Purification and characterization
45. Human skin chymotrypsin-like proteinase chymase: Subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans