The expression of thymidine phosphorylase correlates with angiogenesis and the efficacy of chemotherapy using fluorouracil derivatives in advanced gastric carcinoma

British Journal of Cancer

Volumn 81, Issue 3, 1999, Pages 484-489

  Saito, H ^a   Tsujitani, S ^a   Oka, S ^a   Kondo, A ^a   Ikeguchi, M ^a   Maeta, M ^a   Kaibara, N ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Chemotherapy; Fluorouracil derivative; Gastric cancer; Microvessel; Thymidine phosphorylase

Indexed keywords

CISPLATIN; FLUOROURACIL DERIVATIVE; MITOMYCIN C; TEGAFUR; THYMIDINE PHOSPHORYLASE; UFT;

ADULT; ADVANCED CANCER; AGED; ANGIOGENESIS; ARTICLE; CANCER SURVIVAL; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STOMACH CARCINOMA;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAPILLARIES; COMBINED MODALITY THERAPY; ENZYME INDUCTION; FEMALE; FLUOROURACIL; GASTRECTOMY; GASTRIC MUCOSA; HUMANS; JAPAN; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; STOMACH NEOPLASMS; THYMIDINE PHOSPHORYLASE; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 0032864482     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690719     Document Type: Article

References (27)

1. Bosari S, Lee AKC, Delellis RA, Wiley RD, Heatley GJ and Silverman ML (1992) Microvessel quantitation and prognosis in invasive breast carcinoma. Hum Pathol 23: 755-761
2. Folkman J (1990) What is the evidence that tumours are angiogenesis dependent? J Natl Cancer Inst 82: 4-6
3. Gasparini G, Weidner N, Bevilacqua P, Maluta S, Palma PD, Caffo O, Barbareschi M, Boracchi P, Marubini E and Pozza F (1994) Tumour microvessel density, p53 expression, tumour size, and peritumoural lymphatic vessel invasion are relevant prognostic marker in node-negative breast carcinoma. J Clin Oncol 12: 454-466
4. Griswold DP Jr (1975) The potential for murine tumor models in surgical adjuvant chemotherapy. Cancer Chemother Rep 5: 187-204
5. Hamazoe R, Maeta M and Kaibara N (1994) Intraperitoneal thermochemotherapy for prevention of peritoneal recurrence of gastric cancer. Cancer 73: 2048-2052
6. Haraguchi M, Furukawa T, Sumizawa T and Akiyama S (1993) Sensitivity of human KB cells expressing platelet-derived endothelial cell growth factor to pyrimdine antimetabolites. Cancer Res 53: 5680-5682
7. Ishikawa F, Miyazono K, Hellman U, Drexler H, Wernstedt C, Hagiwara K, Usuki K, Takaku F, Risau W and Heldin CH (1989) Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature 338: 557-562
8. Ishikawa T, Sekiguchi F, Fukase Y, Sawada N and Ishitsuka H (1908) Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts. Cancer Res 58: 685-690
9. Japanese Research Society for Gastric Cancer (1995) Japanese Classification of Gastric Carcinoma. Kanehara, Tokyo
10. Kono A, Hara Y and Matsushima Y (1981) Enzymatic formation of 5-fluorouracil from 1-(tetrahydro-2-furanyl)-5-fluorouracil (tegafur) in human tumor tissues. Chem Pharm Bull 29: 1486-1488
11. Kono H, Hara Y, Sugata S, Karube Y, Matsushima Y and Ishitsuka H (1983) Activation of 5'-deoxy-5-fluorouridine by thymidine phosphorylase in human tumor tissues. Chem Pharm Bull (Tokyo) 31: 175-178
12. Kubota T, Sasano N, Abe O, Nakao I, Kawamura E, Saito T, Endo M, Kimura K, Demura H, Sasano H, Nagura H, Ogawa N and Hoffman RM The Chemosensitivity Study Group for the Histoculture Drug-response Assay (1995) The potential of the histoculture drug response assay to contribute to cancer patient survival. Clin Cancer Res 1: 1537-1543
13. Leichman CG, Lenz HJ, Leichman L, Danenberg K, Baranda J, Groshen S, Boswell W, Metzger R, Tan M and Danenberg PV (1997) Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. J Clin Oncol 15: 3223-3229
14. Lenz HJ, Leichman CG, Danenberg KD, Danenberg PV, Groshen S, Cohen H, Laine L, Crookes P, Silberman H, Baranda J, Garcia Y, Li J and Leichman L (1995) Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival. J Clin Oncol 14: 176-182
15. Maeda K, Chung YS, Takatsuka S, Ogawa Y, Sawada T, Yamashita Y, Onoda N, Kato Y, Nitta A, Arimoto Y, Kondo Y and Sowa M (1995) Tumor angiogenesis as a predictor of recurrence in gastric carcinoma. J Clin Oncol 13: 477-481
16. Maeda K, Chung YS, Ogawa Y, Takatuska S, Kang SM, Ogawa M, Sawada T, Onoda N, Kato Y and Sowa M (1996) Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma. Br J Cancer 73: 884-888
17. Maehara Y, Watanabe A, Kakeji Y, Baba H, Kohnoe S and Sugimachi K (1990) Postoperative prescription of mitomycin C and UFT for patients with stage IV gastric carcinoma. Am J Surg 160: 242-244
18. Moghaddam A and Bicknell R (1992) Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity. Biochemistry 31: 12141-12146
19. Nishida M, Hino A, Mori K, Matsumoto T, Tanaka Y and Ishitsuka H (1994) Cloning of hybridomas producing anti-human thymidine phosphorylase (dThdPase) and establishment ELISA for measuring dThdPase. J Jpn Soc Cancer Ther 29: 1192
20. Palmeri S, Gebbia V, Russo A, Armata MG, Gebbia N and Rausa L (1990) Oral tegafur in the treatment of gastrointestinal tract cancers: a phase II study. Br J Cancer 61: 475-478
21. Schabel FM Jr (1976) Concepts for treatment of micrometastases developed in murine systems. AJR Am J Roentgenol 126: 500-511
22. Schabel FM Jr (1977) Surgical adjuvant chemotherapy of metastatic murine tumors. Cancer 40: 58-68
23. Takebayashi Y, Akiyama Y, Akiba S, Yamada K, Miyadera K, Sumizawa T, Yamada Y, Murata F and Aikou T (1996) Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma. J Natl Cancer Inst 88: 1110-1117
24. Takebayashi Y, Yamada Y, Miyadera K, Sumizawa T, Furukawa T, Kinoshita F, Aoki D, Okumura H, Yamada Y, Akiyama S and Aikou T (1996) The activity and expression of thymidine phosphorylase in human solid tumors. Eur J Cancer 32: 1227-1232
25. Toi M, Hoshina S, Takayanagi T and Tominaga T (1994) Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast carcinoma. Jpn J Cancer Res 85: 1045-1049
26. Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH, Meli S and Gasparini G (1992) Tumour angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst 84: 1875-1887
27. Zagzag D, Miller DC, Sato Y, Rifkin DB and Burstein DE (1990) Immunohistochemical localization of basic fibroblast growth factor in astrocytomas. Cancer Res 50: 7393-7398