Gene-Environment Interactions in Pancreatic Cancer

Pancreatology

Volumn 1, Issue 5, 2001, Pages 472-476

  Malats, N ^a,b  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b INST MUNIC D INVESTIGACIO MEDICA   (Spain)

Author keywords

Environmental factor; Etiology; Family history; Gene environment interaction; Genetic susceptibility; High penetrance gene; Low penetrance gene; Metabolic polymorphism; Pancreatic cancer; Tobacco

Indexed keywords

ENVIRONMENT; GENETICS; HUMAN; PANCREAS TUMOR; PENETRANCE; REVIEW;

ENVIRONMENT; HUMANS; PANCREATIC NEOPLASMS; PENETRANCE;

EID: 0035552240     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000055850     Document Type: Article

References (44)

1. Silverman DT, Dunn JA, Hoover RN, Schiffman M, Lillemoe KD, Schoenberg JB, Brown LM, Greenberg RS, Hayrs RB, Swanson GM, et al: Cigarette smoking and pancreas cancer: A case-control study based on direct interviews. J Natl Cancer Inst 1994;86:1510-1516.
2. Siemiatycki J, Krewski D, Franco E, Kaiserman M: Associations between cigarette smoking and each of 21 types of cancer: A multi-site case-control study. Int J Epidemiol 1995;24: 504-514.
3. Fernandez E, La Vecchia C, Decarli A: Attributable risks for pancreatic cancer in northern Italy. Cancer Epidemiol Biomarkers Prev 1996;5:23-27.
4. Partanen TJ, Vainio HU, Ojajarvi IA, Kauppinen TP: Pancreas cancer, tobacco smoking and consumption of alcoholic beverages: A case-control study. Cancer Lett 1997;116:27-32.
5. Fernandez E, La Vecchia C, Porta M, Negri E, d'Avanzo B, Boyle P: Pancreatitis and the risk of pancreatic cancer. Pancreas 1995;11:185-189.
6. Anderson KE, Potter JD, Mack TM: Pancreatic cancer, in Schottenfeld D, Fraumeni JF Jr (eds): Cancer Epidemiology and Prevention, ed 2. New York, Oxford University Press, 1996, pp 725-771.
7. Silverman DT, Swanson CA, Gridley G, Wacholder S, Greenberg RS, Brown LM, Hayes RB, Swanson GM, Schoenberg JB, Pottern LM, Schwartz AG, Fraumeni JF Jr, Hoover RN: Dietary and nutritional factors and pancreatic cancer: A case-control study based on direct interviews. J Natl Cancer Inst 1998;90: 1710-1719.
8. Ojajarvi IA, Partanen TJ, Ahlbom A, Boffetta P, Hakulinen T, Jourenkova N, Kauppinen TP, Kogevinas M, Porta M, Vainio HU, Weiderpass E, Wesseling CH: Occupational exposures and pancreatic cancer: A meta-analysis. Occup Environ Med 2000;57:316-324.
9. Ghadirian P, Boyle P, Simard A, Baillargeon J, Maisonneuve P, Perret C: Reported family aggregation of pancreatic cancer within a population-based case-control study in the Franco-phone community in Montreal, Canada. Int J Pancreatol 1991;10:183-196.
10. Fernandez E, La Vecchia C, D'Avanzo B, Negri E, Franceschi S: Family history and the risk of liver, gallbladder, and pancreatic cancer. Cancer Epidemiol Biomarkers Prev 1994;3: 209-212.
11. Mangray S, King TC: Molecular pathobiology of pancreatic adenocarcinoma. Front Biosci 1998;3:1148-1160.
12. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K: Environmental and heritable factors in the causation of cancer -analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000;343: 78-85.
13. Flanders TY, Foulkes WD: Pancreatic adenocarcinoma: Epidemiology and genetics. J Med Genet 1996;33:889-898.
14. Cancer risks in BRCA2 mutation carriers. The Breast Cancer Linkage Consortium. J Natl Cancer Inst 1999;91:1310-1316.
15. Goggins M, Kern SE, Offerhaus JA, Hruban RH: Progress in cancer genetics: Lessons from pancreatic cancer. Ann Oncol 1999;10(suppl 4):4-8.
16. Lal G, Liu G, Schmocker B, Kaurah P, Ozcelik H, Narod SA, Redston M, Gallinger S: Inherited predisposition to pancreatic adenocarcinoma: Role of family history and germ-line p16, BRCA1, and BRCA2 mutations. Cancer Res 2000;60:409-416.
17. Lowenfels AB, Maisonneuve P, DiMagno EP, Elitsur Y, Gates LK, Perrault J, Whitcomb DC: Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group. J Natl Cancer Inst 1997; 89:442-446.
18. Neglia JP, FitzSimmons SC, Maisonneuve P, Schoni MH, Schoni-Affolter F, Corey M, Lowenfels AB: The risk of cancer among patients with cystic fibrosis. Cystic Fibrosis and Cancer Study Group. N Engl J Med 1995;332:494-499.
19. Lowenfels AB, Maisonneuve P, Whitcomb DC: Risk factors for cancer in hereditary pancreatitis. International Hereditary Pancreatitis Study Group. Med Clin North Am 2000;84:565-573.
20. Malats N, Casals T, Porta M, Guarner L, Estivill X, Real FX: Cystic fibrosis transmembrane regulator (CFTR) DeltaF508 mutation and 5T allele in patients with chronic pancreatitis and exocrine pancreatic cancer. PANKRAS II Study Group. Gut 2001;48:70-74.
21. Collier JD, Bennett MK, Hall A, Cattan AR, Lendrum R, Bassendine MF: Expression of glutathione S-transferases in normal and malignant pancreas: An immunohistochemical study. Gut 1994;35:266-269.
22. Anderson KE, Hammons GJ, Kadlubar FF, Potter JD, Kaderlik KR, Ilett KF, Minchin RF, Teitel CH, Chou HC, Martin MV, Guengerich FP, Barone GW, Lang NP, Peterson LA: Metabolic activation of aromatic amines by human pancreas. Carcinogenesis 1997;18:1085-1092.
23. Wacke R, Kirchner A, Prall F, Nizze H, Schmidt W, Fischer U, Nitschke FP, Adam U, Fritz P, Belloc C, Drewelow B: Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis. Pancreas 1998;16:521-528.
24. Coles BF, Anderson KE, Doerge DR, Churchwell MI, Lang NP, Kadlubar FF: Quantitative analysis of interindividual variation of glutathione S-transferase expression in human pancreas and the ambiguity of correlating genotype with phenotype. Cancer Res 2000;60:573-579.
25. Minchin RF, Reeves PT, Teitel CH, McManus ME, Mojarrabi B, Ilett KF, Kadlubar FF: N-and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells. Biochem Biophys Res Commun 1992;185:839-844.
26. Thompson PA, Seyedi F, Lang NP, MacLeod SL, Wogan GN, Anderson KE, Tang YM, Coles B, Kadlubar FF: Comparison of DNA adduct levels associated with exogenous and endogenous exposures in human pancreas in relation to metabolic genotype. Mutat Res 1999;424:263-274.
27. Hein DW, McQueen CA, Grant DM, Goodfellow GH, Kadlubar FF, Weber WW: Pharmacogenetics of the arylamine N-acetyltransferases: A symposium in honor of Wendell W. Weber. Drug Mectab Dispos 2000;28:1425-1432.
28. Taylor JA, Umbach DM, Stephens E, Castranio T, Paulson D, Robertson C, Mohler JL, Bell DA: The role of N-acetylation polymorphisms in smoking-associated bladder cancer: Evidence of a gene-gene-exposure three-way interaction. Cancer Res 1998;58:3603-3610.
29. Lee HC, Yoon YB, Kim CY: Association between genetic polymorphisms of the cytochromes P-450 (1A1, 2D6, and 2E1) and the susceptibility to pancreatic cancer. Korean J Intern Med 1997;12:128-136.
30. Liu G, Ghadirian P, Vesprini D, Hamel N, Paradis AJ, Lal G, Gallinger S, Narod SA, Foulkes WD: Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma. Br J Cancer 2000;82:1646-1649.
31. Bartsch H, Malaveille C, Lowenfels AB, Maisonneuve P, Hautefeuille A, Boyle P: Genetic polymorphism of N-acetyltransferases, glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase in relation to malignant and benign pancreatic disease risk. The International Pancreatic Disease Study Group. Eur J Cancer Prev 1998;7:215-223.
32. Porta M, Malats N, Guarner L, Carrato A, Rifa J, Salas A, Corominas JM, Andreu M, Real FX: Association between coffee drinking and K-ras mutations in exocrine pancreatic cancer. PAN-KRASII Study Group. J Epidemiol Community Health 1999;53:702-709.
33. Porta M, Malats N, Jariod M, Grimalt JO, Rifa J, Carrato A, Guarner L, Salas A, Santiago-Silva M, Corominas JM, Andreu M, Real FX: Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. Lancet 1999;354:2125-2129.
34. Weiderpass E, Partanen T, Kaaks R, Vainio H, Porta M, Kauppinen T, Ojajarvi A, Boffetta P, Malats N: Occurrence, trends and environment etiology of pancreatic cancer. Scand J Work Environ Health 1998;24:165-174.
35. Kadlubar FF, Anderson KE, Haussermann S, Lang NP, Barone GW, Thompson PA, MacLeod SL, Chou MW, Mikhailova M, Plastaras J, Marnett LJ, Nair J, Velic I, Bartsch H: Comparison of DNA adduct levels associated with oxidative stress in human pancreas. Mutat Res 1998;405:125-133.
36. Everhart J, Wright D: Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis. JAMA 1995;273:1605-1609.
37. Nadecau JH: Modifier genes in mice and humans. Nat Rev Genet 2001;2:165-174.
38. Potter JD: Colorectal cancer: Molecules and population. J Natl Cancer Inst 1999;91:916-932.
39. Martin AM, Weber BL: Genetic hormonal risk factors in breast cancer. J Natl Cancer Inst 2000;92:1126-1135.
40. Malats N, Porta M, Corominas JM, Pinol JL, Rifa J, Real FX: Ki-ras mutations in exocrine pancreatic cancer: Association with clinicopathological characteristics and with tobacco and alcohol consumption. PANK-ras I Project Investigators. Int J Cancer 1997;70:661-667.
41. Yang Q, Khoury MJ: Evolving methods in genetic epidemiology. III. Gene-environment interaction in epidemiologic research. Epidemiol Rev 1997;19:33-43.
42. Rozenblum E, Schutte M, Goggins M, Hahn SA, Panzer S, Zahurak M, Goodman SN, Sohn TA, Hruban RH, Yeo CJ, Kern SE: Tumor-suppressive pathway in pancreatic carcinoma. Cancer Res 1997;57:1731-1734.
43. Steen HB: The origin of oncogenic mutations: Where is the primary damage? Carcinogenesis 2000;21:1773-1776.
44. Folkman J, Hahnfeldt P, Hlatky L: Cancer: Looking outside the genome. Nat Rev 2000;1: 76-79.