New ribozyme-mimics employing Mg(II) ion as catalytic center

Chemistry Letters

Volumn , Issue 6, 2001, Pages 584-585

  Kuzuya, Akinori ^a   Mizoguchi, Ryo ^a   Komiyama, Makoto ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035533960     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.2001.584     Document Type: Article

References (13)

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9. All the products were purified by reversed-phase HPLC, and fully characterized by MALDI-TOF MS.
10. 2.
11. 0 (data not shown).
12. RNA scission by Mg(II) ion at bulge-site was previously reported: D. Hüsken, G. Goodall, M. J. J. Blommers, W. Jahnke, J. Hall, R. Häner and H. E. Moser, Biochemistry, 35, 16591 (1996). However, the reaction temperature was 60 °C, which was far higher than that (37 °C) employed here. No data on the scission rate were presented there.
13. The combination of this modified DNA with Lu(III) ion site-selectively hydrolyzed RNA: A. Kuzuya, and M. Komiyama, Chem. Lett., 2000, 1378.