Non-covalent combinations of lanthanide(III) ion and two DNA oligomers for sequence-selective RNA scission

Chemistry Letters

Volumn , Issue 10, 1999, Pages 1035-1036

  Kuzuya, Akinori ^a   Akai, Masahiko ^a   Komiyama, Makoto ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033235123     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.1999.1035     Document Type: Article

References (21)

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18. In the double-stranded portion, the negatively-charged transition state is destabilized by the electrostatic repulsion by the phosphate residues. Alternatively, the conformational change of the ribonucleotides, required to proceed from the initial state to the transition state, might be suppressed there.
19. Exactly the same result is presented in the lane 6 in Figure 2.
20. When four bases (A16 to G19) were unpaired, the 3'-side of C18 was additionally cleaved (data not shown).
21. Under the conditions employed in Figure 3, for example, the conversion of RNA hydrolysis by the present system was 5 mol%, whereas that for the covalent conjugate (in Ref. 4a) was 7 mol%.