Power calculations for a general class of tests of linkage and association that use nuclear families with affected and unaffected sibs

Theoretical Population Biology

Volumn 60, Issue 3, 2001, Pages 193-201

  Kaplan, Norman L ^a   Martin, Eden R ^b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Association; Linkage disequilibrium; Nuclear families; TDT

Indexed keywords

DISEASE; GENETICS; STATISTICAL ANALYSIS;

ALLELE; ARTICLE; BIOLOGICAL MODEL; CHROMOSOME MAP; GENE LINKAGE DISEQUILIBRIUM; GENETIC DISORDER; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; HAPLOTYPE; HUMAN; METHODOLOGY; NUCLEAR FAMILY;

ALLELES; CHROMOSOME MAPPING; GENETIC DISEASES, INBORN; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; NUCLEAR FAMILY;

EID: 0035528924     PISSN: 00405809     EISSN: None     Source Type: Journal    
DOI: 10.1006/tpbi.2001.1541     Document Type: Article

References (11)

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5. Tests for linkage and association in nuclear families
6. A weighted sibship disequilibrium test for linkage and association in discordant sibships
7. A test for linkage and association in general pedigrees: The pedigree disequilibrium test
8. Sampling considerations for family-based tests of association
9. Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus
10. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
11. The effect of family structure on linkage tests using allelic association