A truncated isoform of the human β chain common to the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 with increased mRNA expression in some patients with acute leukemia

Blood

Volumn 91, Issue 1, 1998, Pages 54-63

  Gale, Rosemary E ^a   Freeburn, Robin W ^a   Khwaja, Asim ^a   Chopra, Rajesh ^a   Linch, David C ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; INTERLEUKIN 3; INTERLEUKIN 5; MESSENGER RNA; TYROSINE DERIVATIVE;

ACUTE LEUKEMIA; AMINO ACID SEQUENCE; ARTICLE; BETA CHAIN; BLAST CELL; BONE MARROW CELL; CELL INCLUSION; EXON; HUMAN; HUMAN CELL; LEUKEMIA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 0031965459     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.1.54.54_54_63     Document Type: Article

References (46)

1. Metcalf D: The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. Nature 339:27, 1989
2. Fukunaga R, Ishizaka-Ikeda E, Pan C-X, Seto Y, Nagata S: Functional domains of the granulocyte colony-stimulating factor receptor. EMBO J 10:2855, 1991
3. Watowich SS, Yoshimura A, Longmore GD, Hilton DJ, Yoshimura Y, Lodish HF: Homodimerization and constitutive activation of the erythropoietin receptor. Proc Natl Acad Sci USA 89:2140, 1992
4. Miyajima A, Mui AL-F, Ogorochi T, Sakamaki K: Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Blood 82:1960, 1993
5. Taniguchi T, Minami Y: The IL-2/IL-2 receptor system: A current overview. Cell 73:5, 1993
6. Ihle JN: Cytokine receptor signalling. Nature 377:591, 1995
7. Ashworth A, Kraft A: Cloning of a potentially soluble receptor for human GM-CSF. Nucleic Acids Res 18:7178, 1990
8. Hu X, Emanuel PD, Zuckerman KS: Cloning and sequencing of the cDNAs encoding two alternative splicing derived variants of the alpha subunit of the granulocyte-macrophage colony stimulating factor receptor. Biochim Biophys Acta 1223:306, 1994
9. Raines MA, Liu L, Quan SG, Joe V, DiPersio JF, Golde DW: Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor. Proc Natl Acad Sci USA 88:8203, 1991
10. Crosier KE, Wong GG, Mathey-Prevot B, Nathan DG, Sieff CA: A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. Proc Natl Acad Sci US A 88:7744, 1991
11. Devereux S, Wagner HM, Khwaja A, McMillan AK, Linch DC: A novel isoform of the low affinity granulocyte-macrophage colony-stimulating factor receptor. Br J Haematol 84:21, 1993
12. Chopra R, Kendall G, Gale RE, Thomas NSB, Linch DC: Expression of two alternatively spliced forms of the 5′ untranslated region of the GM-CSF receptor α chain mRNA. Exp Hematol 24:755, 1996
13. Wagner HM, Khwaja A, Gale RE, Linch DC: Deletion of the signal peptide sequence in an alternative transcript of the human GM-CSFRα. Proceedings of the Twenty-Fifth Congress of the International Society of Hematology, Cancun, Mexico, April 17-24, 1994, p 185
14. Nakagawa Y, Kosugi H, Miyajima A, Arai K, Yokota T: Structure of the gene encoding the α subunit of the human granulocyte-macrophage colony stimulating factor receptor. J Biol Chem 269: 10905, 1994
15. Nakamura Y, Komatsu N, Nakauchi H: A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells. Science 257:1138, 1992
16. Nakamura Y, Nakauchi H: A truncated erythropoietin receptor and cell death: A reanalysis. Science 264:588, 1994
17. Hayashida K, Kitamura T, Gorman DM, Arai K-I, Yokota T, Miyajima A: Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): Reconstitution of a high affinity GM-CSF receptor. Proc Natl Acad Sci USA 87:9655, 1990
18. Sakamaki K, Miyajima I, Kitamura T, Miyajima A: Critical cytoplasmic domains of the common β subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation. EMBO J 11:3541, 1992
19. Sato N, Sakamaki K, Terada N, Arai K-I, Miyajima A: Signal transduction by the high-affinity GM-CSF receptor: Two distinct cytoplasmic regions of the common β subunit responsible for different signaling. EMBO J 12:4181, 1993
20. Smith A, Metcalf D, Nicola NA: Cytoplasmic domains of the common β-chain of the GM-CSF/IL-3/IL-5 receptors that are required for inducing differentiation or clonal suppression in myeloid leukaemic cell lines. EMBO J 16:451, 1997
21. Murakami M, Narazaki M, Hibi M, Yawata H, Yasukawa K, Hamaguchi M, Taga T, Kishimoto T: Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family. Proc Natl Acad Sci USA 88:11349, 1991
22. Witthuhn BA, Quelle FW, Silvennoinen O, Yi T, Tang B, Miura O, Ihle JN: JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 74:227, 1993
23. Quelle FW, Sato N, Witthuhn B, Inhorn RC, Eder M, Miyajima A, Griffin JD, Ihle JN: JAK2 associates with the βc chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol Cell Biol 14:4335, 1994
24. Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A: A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J 14:2816, 1995
25. Kinoshita T, Yokota T, Arai K-I, Miyajima A: Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors. EMBO J 14:266, 1995
26. Itoh T, Liu R, Arai K, Watanabe S: Roles of tyrosine phosphorylation of the receptor β subunit in human GM-CSF signal transduction. Blood 88:446a, 1996 (suppl 1, abstr)
27. Kitamura T, Tange T, Terasawa T, Chiba S, Kuwaki T, Miyagawa K, Piao Y-F, Miyazono K, Urabe A, Takaku F: Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J Cell Physiol 140:323, 1989
28. Collins SJ, Gallo RC, Gallagher RE: Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture. Nature 270:347, 1977
29. Sundstrom C, Nilsson K: Establishment and characterization of a human histiocytic lymphoma cell line (U-937). Int J Cancer 17:565, 1976
30. Gillis S, Smith KA: Long term culture of tumour-specific cytotoxic T cells. Nature 268:154, 1977
31. Sambrook J, Fritsch EF, Maniatis T: Molecular cloning: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1989, p 7.19
32. Gearing DP, King JA, Gough NM, Nicola NA: Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J 8:3667, 1989
33. Harlow E, Lane D: Antibodies: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1988
34. Shen Y, Baker E, Callen DF, Sutherland GR, Willson TA, Rakar S, Gough NM: Localization of the human GM-CSF receptor β chain gene (CSF2RB) to chromosome 22q12.2 → q13.1. Cytogenet Cell Genet 61:175, 1992
35. Gorman DM, Itoh N, Jenkins NA, Gilbert DJ, Copeland NG, Miyajima A: Chromosomal localization and organization of the murine genes encoding the β subunits (AIC2A and AIC2B) of the interleukin 3, granulocyte/macrophage colony-stimulating factor, and interleukin 5 receptors. J Biol Chem 267:15842, 1992
36. Youssoufian H, Longmore G, Neumann D, Yoshimura A, Lodish HF: Structure, function, and activation of the erythropoietin receptor. Blood 81:2223, 1993
37. Cannistra SA, Koenigsmann M, DiCarlo J, Groshek P, Griffin JD: Differentiation-associated expression of two functionally distinct classes of granulocyte-macrophage colony-stimulating factor receptors by human myeloid cells. J Biol Chem 265:12656, 1990
38. Budel LM, Hoogerbrugge H, Pouwels K, van Buitenen C, Delwel R, Lowenberg B, Touw IP: Granulocyte-macrophage colony-stimulating factor receptors alter their binding characteristics during myeloid maturation through up-regulation of the affinity converting β subunit (KH97). J Biol Chem 268:10154, 1993
39. Khwaja A, Carver J, Jones HM, Linch DC: Dynamic modulation of the cell surface expression of the granulocyte-macrophage colony-stimulating factor receptor. Br J Haematol 85:42, 1993
40. Tanner JW, Chen W, Young RL, Longmore GD, Shaw AS: The conserved box 1 motif of cytokine receptors is required for association with JAK kinases. J Biol Chem 270:6523, 1995
41. Watanabe S, Itoh T, Arai K-I: JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells. J Biol Chem 271:12681, 1996
42. Itoh T, Muto A, Watanabe S, Miyajima A, Yokota T, Arai K: Granulocyte-macrophage colony-stimulating factor provokes RAS activation and transcription of c-fos through different modes of signalling. J Biol Chem 271:7587, 1996
43. Jenkins BJ, D'Andrea R, Gonda TJ: Activating point mutations in the common β subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of β subunit dimerization and cell type-specific molecules in signalling. EMBO J 14:4276, 1995
44. Muto A, Watanabe S, Miyajima A, Yokota T, Arai K: The β subunit of human granulocyte-macrophage colony-stimulating factor receptor forms a homodimer and is activated via association with the α subunit. J Exp Med 183:1911, 1996
45. Dong F, van Buitenen C, Pouwels K, Hoefsloot LH, Lowenberg B, Touw IP: Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturation. Mol Cell Biol 13:7774, 1993
46. Dong F, Byrnes RK, Tidow N, Weite K, Lowenberg B, Touw IP: Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. N Engl J Med 333:487, 1995