Sugar additives for MALDI matrices improve signal allowing the smallest nucleotide change (A:T) in a DNA sequence to be resolved

Nucleic Acids Research

Volumn 29, Issue 19, 2020, Pages

  Shahgholi, Mona ^a   Garcia, Benjamin A ^a   Chiu, Norman H L ^a,b   Heaney, Paul J ^a   Tang, Kai ^a  

^a SEQUENOM INC   (United States)

^b BOSTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FRUCTOSE; FUCOSE; GLUCOSAMINE; GLUCOSE; N ACETYLGLUCOSAMINE; OLIGONUCLEOTIDE; SUGAR; TREHALOSE; DEOXYADENOSINE PHOSPHATE; PYRIMIDINE NUCLEOTIDE;

ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DESORPTION; DNA SEQUENCE; ENERGY TRANSFER; GENE MUTATION; HETEROZYGOTE; INFORMATION PROCESSING; IONIZATION; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; MEASUREMENT; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; CHEMISTRY; EVALUATION; HUMAN; MASS SPECTROMETRY; METHODOLOGY; NUCLEOTIDE SEQUENCE; SENSITIVITY AND SPECIFICITY;

DEOXYADENINE NUCLEOTIDES; DNA MUTATIONAL ANALYSIS; FRUCTOSE; FUCOSE; HUMANS; OLIGONUCLEOTIDES; POLYMORPHISM, SINGLE NUCLEOTIDE; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; THYMINE NUCLEOTIDES;

MLCS; MLOWN;

EID: 0035489785     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/29.19.e91     Document Type: Article

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