NFκB Polymorphisms and susceptibility to type 1 diabetes

Genes and Immunity

Volumn 2, Issue 6, 2001, Pages 304-308

  Hegazy, D M ^a   O'Reilly, D A ^a   Yang, B M ^a   Hodgkinson, A D ^a   Millward, B A ^a   Demaine, A G ^a,b  

^a PLYMOUTH UNIVERSITY PENINSULA SCHOOLS OF MEDICINE AND DENTISTRY   (United Kingdom)

^b ITTC Building ^*  (United Kingdom)

Author keywords

Diabetic complications; Hyperglycaemia; Nuclear factor kappa B; Type 1 diabetes

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICROSATELLITE DNA;

ADOLESCENT; ADULT; ALLELE; ARTICLE; AUTORADIOGRAPHY; CAUCASIAN; CHILD; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; DINUCLEOTIDE REPEAT; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; ONSET AGE; UNITED KINGDOM;

ADOLESCENT; ADULT; AGE OF ONSET; ALLELES; AUTORADIOGRAPHY; CHILD; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; DIABETIC RETINOPATHY; DINUCLEOTIDE REPEATS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GREAT BRITAIN; HUMANS; MALE; MICROSATELLITE REPEATS; NF-KAPPA B; POLYMORPHISM, GENETIC;

EID: 0035487255     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6363776     Document Type: Article

References (28)

1. Platz P, Jakobsen BK, Morling N et al. HLA-D and DR antigens in genetic analysis of insulin-dependent diabetes mellitus. Diabetologia 1981; 21: 108-115.
2. Wolf E, Spencer KM, Cudworth AG. The genetic susceptibility to type 1 diabetes: analysis of the HLA-DR association. Diabetologia 1983; 24: 224-230.
3. Todd JA. Genetic analyses of type 1 diabetes using whole genome approaches. Proc Natl Acad Sci 1995; 92: 8560-8565.
4. Hashimoto L, Habita C, Beressi JP et al. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature 1994; 371: 161-164.
5. Merriman TR, Todd JA. Genetics of insulin-dependent diabetes: non-major histocompatibility genes. Horm Metab Res 1996; 28: 289-293.
6. Field LL, Tobias R. Unravelling a complex trait: the genetics of insulin-dependent diabetes mellitus. Clin Invest Med 1997; 20: 41-49.
7. Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986; 46: 705-716.
8. Le Beau MM, Ito C, Cogswell P, Espinosa R 3d, Fernald AA, Baldwin AS Jr. Chromosomal localisation of the genes encoding the p50/p105 subunits of NF-kappa B (NFKB2) and the I kappa B/MAD-3 (NFKBI) inhibitor of NF-kappa B to 4q24 and 14q13, respectively. Genomics 1992; 14: 529-531.
9. Brand K, Page S, Rogler G et al. Activated transcription factor nuclear factor-kappa B is present in the artherosclerotic lesion. J Clin Invest 1996; 97: 1715-1722.
10. Baeuerle PA. The inducible transcription factor NF-κB: regulation by distinct protein subunits. Biochim Biophys Acta 1991; 1072: 63-80.
11. Baeuerle PA, Baltimore D. NF-κB: ten years after. Cell 1996; 87: 13-20.
12. Barnes PJ, Karin M. Nuclear factor κB - a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997; 336: 1066-1071.
13. Du X, Stockklauser-Farber K, Rosen P. Generation of reactive oxygen intermediates, activation of NF-κB, and induction of apoptosis in human endothelial cells by glucose: role of nitric oxide synthase. Free Radic Biol Med 1999; 27: 752-763.
14. The Diabetes Control and Complications Trial Research group. The effect of intensive treatment of diabetes on the development and progression of long -term complications in insulin dependent diabetes mellitus. N Engl J Med 1993; 329: 977-986.
15. Greene D, Lattimer SA, Sima AAF. Sorbitol, phospho-inositides and sodium-potassium-ATPase in the pathogenesis of diabetic complications. N Engl J Med 1987; 316: 599-606.
16. Williamson JR, Chang K, Frangos M et al. Hyperglycaemic pseudohypoxia and diabetic complications. Diabetes 1993; 42: 801-813.
17. Friedman EA. Advanced glycosylated end products and hyperglycaemia in the pathogenesis of diabetic complications. Diabetes Care 1999; 22: 65-71.
18. Ceriello A. Hyperglycaemia: the bridge between non-enzymatic glycation and oxidative stress in the pathogenesis of diabetic complications. Diabetes Nutr Metab 1999; 12: 42-46.
19. Mohamed AK, Bierhaus A, Schiekofer S et al. The role of oxidative stress and NF-Kappa B activation in late diabetic complications. Biofactors 1999; 10: 157-167.
20. Hoffmann MA, Schiekofer S, Isermann B et al. Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increase activation of the oxidative-stress sensitive transcription factor NF-κB. Diabetologia 1999; 42: 222-232.
21. Yerneni KKV, Bai W, Khan BV, Medford RM, Natarjan R. Hyperglycaemia-induced activation of nuclear transcription factor κB in vascular smooth muscle cells. Diabetes 1999; 48: 855-864.
22. Quehenberger PB. Endothelin-1 transcription is controlled by Nuclear Factor-κB in AGE-stimulated cultured endothelial cells. Diabetes 2000; 49: 1561-1570.
23. Ota N, Nakajima T, Shirai Y, Emi M. Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the human nuclear factor kappa-beta subunit 1 (NFKB1) locus. J Hum Genet 1999; 44: 129-130.
24. Pravica V, Asderakis A, Perrey C, Hajeer A, Sinnott PJ, Hutchinson I. In vitro production of IFN gamma correlates with CA repeat polymorphism in the human IFN gamma gene. Europe J Immunogenet 1999; 26: 1-3.
25. Fishman D, Faulds G, Jeffery R et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998; 7: 1369-1376.
26. Rim JS, Atta MG, Dahl SC et al. Transcription of the sodium/myo-inositol cotransporter gene is regulated by multiple tonicity responsive enhancers spread over 50 kilobase pairs in the 5′-flanking region. J Biol Chem 1998; 273: 20615-20621.
27. Heesom AE, Millward BA, Domaine AG. Susceptibility to diabetic neuropathy in patients with insulin dependent diabetes mellitus is associated with a polymorphism at the 5′-end of the aldose reductase gene. J Neurol Neurosurg Psy 1998; 64: 213-216.
28. Tiwari JL, Terasaki PI. The data and statistical analysis. In: HLA and Disease Associations. Springer-Verlag: New York, 1985, pp 18-27.