Alterations in hippocampal non-phosphorylated MAP2 protein expression in schizophrenia

Brain Research

Volumn 765, Issue 2, 1997, Pages 238-246

  Cotter, David ^a   Kerwin, Robert ^a   Doshi, Bala ^a   Martin, Carlos Sanchez ^b   Everall, Ian Paul ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Densitometry; Intemeuronal distance; MAP2; Neuronal orientation; Phosphorylation; Schizophrenia

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN 2;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DENSITOMETRY; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; INTERNEURON; MALE; NERVE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHIZOPHRENIA; SUBICULUM;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HIPPOCAMPUS; HUMANS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; PHOSPHORYLATION; SCHIZOPHRENIA;

EID: 0030982394     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00575-1     Document Type: Article

References (47)

1. S. Akbarian, A. Vinuela, J. Kimm, S.G. Potkin, W.E. Bunney, E.G. Jones, Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in temporal lobe of schizophrenics implies disturbances of cortical development, Arch. Gen. Psychiatry 50 (1993) 178-187.
2. S. Akbarian, J. Kimm, S.G. Potkin, W. Hetrick, W.E. Bunney, E.G. Jones, Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients, Arch. Gen. Psychiatry 53 (1993) 425-436.
3. L. Altshuler, A. Conrad, J.A. Kovelman, A.B. Scheibel, Hippocampal pyramidal cell orientation in schizophrenia, Arch. Gen. Psychiatry 44 (1987) 1094-1098.
4. D.G. Amaral, R. Insausti, Hippocampal formation, in: Paxinos, G. (Ed.), The Human Nervous System, Academic Press, 1990, pp. 711-756.
5. S. Anderson, D. Volk, D.A. Lewis, Increased density of microtubule associated protein 2-immunoreactive neurons in the prefrontal white matter of schizophrenic subjects, Schizophr. Res. 19 (1996) 1211-1219.
6. S.E. Arnold, V.M.Y. Lee, R.E. Gur, J.Q. Trojanowski, Abnormal expression of two microtubule associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia, Proc. Natl. Acad. Sci. USA 88 (1991) 10850-10854.
7. S.E. Arnold, B.T. Hyman, G.W.V. Hoesen, A.R. Damasio, Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia, Arch. Gen. Psychiatry 48 (1991) 625-632.
8. S.E. Arnold, B.R. Franz, R.C. Gur, R.E. Gur, R.M. Shapiro, P.J. Moberg, J.Q. Trojanowski, Smaller interneuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions, Am. J. Psychiatry 152 (1995) 738-748.
9. S.E. Arnold, J.Q. Trojanowski, Recent advances in defining the neuropathology of schizophrenia, Acta Neuropathol. 92 (1996) 217-231.
10. S. Bazire, Psychotropic Drug Directory, Mark Allen Publishing, Wilts, 1995.
11. F.M. Benes, J. Davidson, E.D. Bird, Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics, Arch. Gen. Psychiatry 43 (1986) 31-35.
12. F.M. Benes, E.D. Bird, An analysis of the arrangement of neurons in the cingulate cortex of schizophrenic patients, Arch. Gen. Psychiatry 44 (1987) 608-616.
13. F.M. Benes, I. Sorensen, E.D. Bird, Reduced neuronal size in the posterior hippocampus of schizophrenic patients, Schizophr. Bull. 17 (1991) 597-608.
14. B. Bogerts, E. Meertz, R. Schonfeldt-Bausch, Basal ganglia and limbic system pathology in schizophrenia: a morphometric study of brain volume and shrinkage, Arch. Gen. Psychiatry 42 (1985) 784-791.
15. M.D. Browning, E.M. Dudeck, J.L. Rapier, S. Leonard, R. Freedman, Significant reductions in synapsin but not synaptophysin specific activity in the brains of some schizophrenics, Biol. Psychiatry 34 (1993) 528-535.
16. G.W. Christison, M.F. Casanova, D.F. Weinberger, R. Rawlings, J.E. Kleinman, A quantitative investigation of hippocampal pyramidal cell size, shape, and variation of orientation in schizophrenia, Arch. Gen. Psychiatry 46 (1989) 1027-1032.
17. A.J. Conrad, A.B. Scheibel, Schizophrenia and the hippocampus: the embryological hypothesis extended, Schizophr. Bull. 13 (1987) 577-587.
18. A.J. Conrad, T. Abebe, A. Ron, S. Forsythe, B. Scheibel, Hippocampal pyramidal cell disarray in schizophrenia as a bilateral phenomenon, Arch. Gen. Psychiatry 48 (1991) 413-417.
19. T. Crow, J. Ball, S. Bloom, Schizophrenia as an anomaly of development of cerebral asymmetry: a postmortem study and a proposal concerning their genetic basis of the disease, Arch. Gen. Psychiatry 46 (1989) 1145-1150.
20. S.L. Eastwood, P.J. Burnet, P.J. Harrison, Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia, Neuroscience 66 (1995) 201-206.
21. P. Falkai, B. Bogerts, Cell loss in the hippocampus of schizophrenics, Eur. Arch. Psychiatry Neurol. Sci. 236 (1986) 154-161.
22. P. Falkai, B. Bogerts, M. Rozumek, Limbic pathology in schizophrenia: the internal region - a morphometric study, Biol. Psychiatry 24 (1988) 515-521.
23. P. Falkai, B. Bogerts, T. Schneider, B. Greve, U. Pfeiffer, K. Pilz, C. Gonsiorzcyk, C. Majtenyi, I. Ovary, Disturbed planum temporale asymmetry in schizophrenia. A quantitative postmortem study, Schizophr. Res. 14 (1993) 161-176.
24. P.J. Harrison, D. McLaughlin, R.W. Kerwin, Decreased hippocampal expression of glutamate receptor gene in schizophrenia, Lancet 337 (1991) 450-452.
25. S. Heckers, Y.C. Heinsen, B. Geiger, H. Beckmann, Hippocampal neuron number in schizophrenia. A stereological study, Arch. Gen. Psychiatry 48 (1991) 1002-1008.
26. H. Jacob, H. Beckmann, Prenatal development disturbances in the limbic allocortex in schizophrenics, J. Neural Transm. 65 (1986) 303-326.
27. D.V. Jeste, J.B. Lohr, Hippocampal pathologic findings in schizophrenia: a morphometric study, Arch. Gen. Psychiatry 46 (1989) 1019-1024.
28. R.W. Kerwin, S. Patel, B.S. Meldrum, C. Czudek, G. Reynolds, Asymmetrical loss of glutamate receptor subtype in the left hippocampus in schizophrenia, Lancet i (1988) 583-584.
29. R.W. Kerwin, S. Patel, B.S. Meldrum, Autoradiographic localisation of the glutamate receptor system in control and schizophrenic post-mortem hippocampal formation, Neuroscience 39 (1990) 25-32.
30. R.W. Kerwin, Glutamate receptors, microtubule associated proteins and developmental anomaly in schizophrenia: an hypothesis, Psychol. Med. 23 (1993) 547-551.
31. J.A. Kovelman, A.B. Scheibel, A neurohistological correlate of schizophrenia, Biol. Psychiatry 19 (1984) 1601-1621.
32. R. Lorento de No, Studies on the structure of the cerebral cortex II: continuation on the study of the ammonic system, J. Psychol. Neurol. 46 (1934) 113-177.
33. K.V. Mardia, Statistics of Directional Data, Academic Press, London, 1972.
34. R.M. Murray, E. O'Callaghan, D.J. Castle, S.W. Lewis, A neurodevelopmental approach to the classification of schizophrenia, Schizophr. Bull. 18 (2) (1992) 319-322.
35. P.G. Moore, Spacing in plant populations, Ecology 35 (1954) 222-227.
36. J. Nunez, Differential expression of microtubule components during brain development, Dev. Neurosci. 8 (1986) 125-141.
37. G.W. Roberts, N. Colter, R. Lofthouse, E.C. Johnstone, T.J. Crow, Is there gliosis in schizophrenia? Investigation of the temporal lobe, Biol. Psychiatry 22 (1987) 1459-1468.
38. M.A. Rosoklija, D. Kaufman, A.P. Liu, N. Hays, C. Latov, A. Kielp, A. Wu, J. Sadiq, I. German, A.J. Prohovnik, A.J. Dwork, Subicular MAP-2 immunoreactivity in schizophrenia, Soc. Neurosci. Abstr. 21 (1995) 21216.
39. C. Sanchez, J. Diaz-Nido, J. Avila, Variations in vivo phosphorylation at the proline-rich domain of the microtubule associated protein 2 (MAP2) changes during rat development, Biochem. J. 306 (2) (1995) 481-487.
40. C. Sanchez, P. Tompa, K. Szucs, P. Freidrich, J. Avila, Phosphorylation and dephosphorylation in the proline-rich C-terminal domain of microtubule associated protein2, Eur. J. Biochem. 241 (1996) 765-771.
41. A.B. Scheibel, J.A. Kovelman, Disorientation of the hippocampal pyramidal cell and its processes in the schizophrenic patient, Biol. Psychiatry 16 (1981) 101-102.
42. A.B. Scheibel, A.S. Conrad, Hippocampal dysgenesis in mutant mouse and schizophrenic man: is there a relationship?, Schizophr. Bull. 19 (1) (1993) 21-33.
43. C. Schwab, V. Bondada, L. Sparks, L.D. Cahan, J.W. Geddes, Postmortem changes in the levels and localisation of microtubule associated proteins (TAU, MAP2 and MAP1B) in the rat and human hippocampus, Hippocampus 4 (2) (1994) 210-225.
44. R.L. Suddath, G.W. Christison, E.F. Torrey, M. Casanova, D.R. Weinberger, Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia, N. Engl. J. Med. 322 (1990) 789-794.
45. D.J. Weinberger, Implications of normal brain development for the pathogenesis of schizophrenia, Arch. Gen. Psychiatry 44 (1987) 660-669.
46. G.J. Upton, B. Fingleton, Spatial Data Analysis by Example, vol. 1, John Wiley and Sons, 1985, pp. 118-133.
47. G.J. Upton, B. Fingleton, Spatial Data Analysis by Example, vol. 2, John Wiley and Sons, 1989, pp. 207-226.