Effects of Endogenous Acetaldehyde Production by Disulfiram and Ethanol Feeding on Rat Pancreas

Journal of Gastrointestinal Surgery

Volumn 5, Issue 5, 2001, Pages 531-539

  He, Zhi Jun ^a   Eriksson, Peter ^b   Alho, Hannu ^b   Harmoinen, Aimo ^a   Nordback, Isto ^a  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Acetaldehyde; Acute alcoholic pancreatitis; Disulfiram; Histopathology; Liver changes

Indexed keywords

ACETALDEHYDE; ALCOHOL; DISULFIRAM;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; COMPARATIVE STUDY; DRUG EFFECT; ELECTRON MICROSCOPY; LIPID METABOLISM; LIVER; LIVER CELL; MALE; METABOLISM; PANCREAS; RAT; ULTRASTRUCTURE; WISTAR RAT;

ACETALDEHYDE; ANIMALS; BEHAVIOR, ANIMAL; DISULFIRAM; ETHANOL; HEPATOCYTES; LIPID METABOLISM; LIVER; MALE; MICROSCOPY, ELECTRON; PANCREAS; RATS; RATS, WISTAR;

EID: 0035469532     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1091-255X(01)80092-5     Document Type: Article

References (37)

1. Singh M, Simsek H. Ethanol and pancreas. Current status. Gastroenterology 1990;98:1051-1062.
2. Wilson JS, Priola RC. Pathogenesis of alcoholic pancreatitis. Aust N Z J Med 1983;13:307-312.
3. Fitzpatrick J, Fitzgerald O, Fitzgerald P, McGeeney KF. The effect of acetaldehyde on the totally isolated canine pancreas. Biol Gastroenterol (Paris) 1975;8:363,
4. Geokas MC. Ethanol and pancreas. Med Clin North Am 1984;68:57-75.
5. Nordback I, MacGowan S, Potter JJ, Cameron JL. The role of acetaldehyde in the pathogenesis of acute alcoholic pancreatitis. Ann Surg 1991;214:671-678.
6. Nordback I, Olson JL, Chacko VP, Cameron JL. Detailed characterization of experimental acute alcoholic pancreatitis. Surgery 1995;117:41-49.
7. Fridovich I. Oxygen radicals from acetaldehyde. Free Rad Biol Med 1989;7:557-558.
8. Stewart MJ, MaLek K, Crabb DW. Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J Investig Med 1996;44:42-46.
9. Ambroziak W, Maslinski C. Participation of aldehyde dehy-drogenase in the oxidative deamitiation pathway of histamine and putrescine. Agents Actions 1988;23:311-313.
10. Deitrich KA, Erwin VG. Mechanism ofthe inhibition of aldehyde dehydrogenase in vivo by disulfiram and diethylthiocarbaraate. Mol Pharmacol 1971;7:301-307.
11. Kitson TM. The effect of disulfiram on aldehyde dehydrogenase of sheep liver. Biochem J 1975;151:407-412.
12. Shimada J, Miyahara T, Otsubo S, et al. Effects of alcoholmetabolizing enzyme inhibitors and beta-lactam antibiotics on ethanol elimination in rats. Jpn J Pharmacol 1987;45:533-544.
13. The Committee on Enzymes of the Scandinavian Society for Clinical Chemistry and Physiology. Recommended methods for the determination of four enzymes in blood, Scand J Clin Lab Invest 1974;33:291-306.
14. Eriksson CJ, Sippel HW, Forsander OA. The determination of acetaldchyde in biological samples by head-space gas chromatography. Anal Biochem 1977;80:116-124.
15. Parks DA, Granger DN. Xanthine oxidase: Biochemistry, distribution and physiology. Acta Physiol Scand (Suppl) 1986; 548:87-99.
16. Granger DN. Role of xanthine oxidase and granulocytes in ischemia-reperfusion. Am J Physiol 1988;255:H1269-H1275.
17. Skibba JL, Powers RH, Stadnicka A, Kalbfleisch JH. The effect of hyperthermia of conversion of rat hepatic xanthine dehydrogenase to xanthine oxidase. Biochem Pharmacol 1988; 37:4592-4595.
18. Battelli MG, Lorenzoni E, Stirpe F. Milk xanthine oxidase type D (dehydrogenase) and type O (oxidase). Purification, interconversion and some properties. Biochem J 1973;131: 191-198.
19. Stark K, Seubert P, Lynch G, Baudry M. Proteolytic conversion of xanthine dehydrogenase to xanthine oxidase: Evidence against calcium-activated protease (calpain). Biochem Biophys Res Commun 1989;165:858-864.
20. Sultatos LG. Effects of acute ethanol administration on the hepatic xanthine dehydrogenase/oxidase system in the rat. J Pharmacol Exp Ther 1988;246:946-949.
21. Nordback I, Cameron JL. The mechanism of conversion of xanthine dehydrogenase to xanthine oxidase in acute pancreatitis in the canine isolated pancreas preparation. Surgery 1993;113:90-97.
22. Majumdar APN, Vesenka GD, Dubick MA, et al. Morphological and biochemical changes of the pancreas in rats treated with acetaldehyde. Am J Physiol 1986;250:G598-G606.
23. Hjorttrop A, Andersen N, Kreutzfeld M, et al. Effect of intra-arterial administration of acetaldehyde on pig pancreas. Dan Med Bull 1983;30:125-127.
24. Dietrich RA. Tissue and subcellular distribution of mammalian acetaldehyde-oxidizing capacity. Biochem Pharmacol 1966;15:1911-1922.
25. 5. Beyeler C, Fisch HU, Preisig R. The disulfiram-alcohol reaction: Factors determining and potential tests predicting severity. Alcoholism 1985;9:118-124.
26. Johansson B, Angelo HR, Christensen JK, et al. Dose-effect relationship of disulfiram in human volunteers. II: A study of the relation between the disulfiram-alcohol reaction and plasma concentrations of acetaldehyde, diethyldithiocarbamic acid methyl ester, and erythrocyte aldehyde dehydrogenase activity. Pharmacol Toxicol 1991;68:166-170.
27. Johnsen J, Stowell A, Mørland J. Clinical responses in relation to blood acetaldehyde levels. Pharmacol Toxicol 1992;70: 41-45.
28. Jaakkola M, Sillanaukee P, Suomalainen H, et al. Effect of a high dose of ethanol on scrum pancreatic enzymes in young healthy adults. Am J Gastroenterol 1992;87:461-464.
29. Jaakkola M, Frey T, Sillanaukee P, et al. Acute pancreatic in-jury in asymptomatic individuals after heavy drinking over the long-term. Hepatogastroenterology 1994;41:477-482.
30. Jaakkola M, Sillanaukee P, Löf K, et al. Amount of alcohol is an important determinant of the severity of acute alcoholic pancreatitis. Surgery 1994;115:31-38.
31. Jaakkola M, Nordback I. Pancreatitis in Finland between 1970 and 1989. Gut 1993;34:1255-1260.
32. Eriksson CJ, Fukunaga T. Human blood acetaldehyde (update 1992). Alcohol Alcohol Suppl 1993-2:9-25.
33. Werner J, Laposata M, Fernández-del Castillo C, et al. Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol. Gastroenterology 1997;113:286-294.
34. Volenrine GD, Ogden KA, Kortje DK, et al. Role of acetaldehyde in the ethanol-induced impairment of hepatic glycoprotein secretion in the rat in vivo. Hepatology 1987;7:490-495.
35. Gutierrez-Ruiz MC, Quiroz SC, Souza V, et al. Cytokines, growth factors, and oxidative stress in HepG2 cells treated with ethanol, acetaldehyde, and LPS. Toxicology 1999;134: 197-207.
36. Majumdar AP, Haiman MJ, Zylbert BA, et al. Acetaldehyde inhibition of protein synthesis in isolated rat pancreatic acini, Toxicol Pharmacol 1986;83:86-94.
37. Steer ML. Frank Brooks Memorial Lecture: The early intraacinar cell events which occur during acute pancreatitis. Pancreas 1998;17:31-37.