Preoperative radiotherapy for rectal cancer: Hypofractionation with multiple fractions (15-25 Gy)

Annali Italiani di Chirurgia

Volumn 72, Issue 5, 2001, Pages 539-547

  Glimelius, B ^a   Pahlman L ^b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b Department of Surgery   (Sweden)

Author keywords

Adjuvant; Dose response relationship; Radiotherapy; Rectal neoplasms; Treatment outcome

Indexed keywords

ABDOMINAL SURGERY; ADJUVANT THERAPY; HUMAN; METHODOLOGY; MORTALITY; POSTOPERATIVE COMPLICATION; PREOPERATIVE CARE; RADIATION DOSE FRACTIONATION; RECTUM TUMOR; REVIEW; TUMOR RECURRENCE;

DIGESTIVE SYSTEM SURGICAL PROCEDURES; DOSE FRACTIONATION; HUMANS; NEOPLASM RECURRENCE, LOCAL; POSTOPERATIVE COMPLICATIONS; PREOPERATIVE CARE; RADIOTHERAPY, ADJUVANT; RECTAL NEOPLASMS;

EID: 0035468321     PISSN: 2239253X     EISSN: 2239253X     Source Type: Journal    
DOI: None     Document Type: Article

References (69)

1. Glimelius B., Pahlman L.: Perioperative radiotherapy in rectal cancer. Acta Oncol, 38:23-32, 1999.
2. Enker W.E.: Total mesorectal excision-the new golden standard of surgery for rectal cancer. Ann Med, 29:127-133, 1997.
3. MacFarlane J.K., Ryall R.D.H., Heald R.J.: Mesorectal excision for rectal cancer. Lancet, 341:457-460, 1993.
4. Dahlberg M., Glimelius B., Pahiman L.: Changing strategy for rectal cancer is associated with improved outcome. Br J Surg, 86:379-84, 1999.
5. Lehander Martling A., Holm T., Rutqvist L.E. et al.: Effect of a surgical training programme on outcome of rectal cancer in the County of Stockholm. Lancet, 356:93-96, 2000.
6. Moriya Y., Hojo K., Sawada T. et al.: Significance of lateral node dissection for advanced rectal carcinoma at or below the peritoneal reflection. Dis Colon Rectum, 32:307-315, 1989.
7. Withers H.R., Peters L.J., Taylor J.M.G.: Dose-response relationship fir radiation therapy of subclinical disease. Int J Radiat Oncol Biol Phys, 31:353-359, 1995.
8. Fletcher G.H.: Subclinical disease. Cancer, 53:1274-1284, 1984.
9. Fowler J.F.: The linear-quadratic formula and progress in fractionated radiotherapy. Br J Radiol, 62:679-694, 1989.
10. Glimelius B., Isacsson U., Jung B. et al.: Radiotherapy in addition to radical surgery in rectal cancer: evidence for a dose-response effect favouring preoperative treatment. Int J Radiat Oncol Biol Phys, 37:281-287, 1997.
11. Letschert J.G.J., Lebesque J.V., R W de Boer et al.: Dose-volume correlation in radiation-induced late small-bowel complications: a clinical study. Radiother Oncol, 18:307-320, 1990.
12. Frykholm-Jansson G., Isacsson U., Sintorn K. et al.: Preoperative radiotherapy in rectal carcinoma-aspects of adverse effects and radiation technique. Int J Radiat Oncol Biol Phys, 35:1039-1048, 1996.
13. Rider W.D., Palmer J.A., Mahoney L.J. et al.: Preoperative irradiation in operable cancer of the rectum: Report of the Toronto trial. Can J Surg, 20:335-338, 1977.
14. Duncan W., Smith A.N., Freedman L.S. et al.: The evaluation of low dose pre-operative X-ray therapy in the management of operable rectal cancer, results of a randomly controlled trial. Br J Surg, 71:21-25, 1984.
15. Sause W.T., Pajak T.F., Noyes R.D. et al.: Evaluation of preoperative radiation therapy in operable colorectal cancer. Ann Surg, 220:668-75, 1994.
16. Goldberg P.A., Nicholls R.J., Porter N.H. et al.: Long-term results of a randomised trial of short-course low-dose adjuvant pre-operative radiotherapy for rectal cancer: Reduction in local treatment failure. Eur J Cancer, 30A: 1602-1606, 1994.
17. Marsh P.J., James R.D., Schofield P.F.: Adjuvant preoperative radiotherapy for locally advanced rectal carcinoma. Results of a prospective, randomized trial. Dis Colon Rectum, 37:1205-1214, 1994.
18. Stockholm Rectal Cancer Study Group.: Preoperative short-term radiation therapy in operable rectal carcinoma. A prospective randomized trial. Cancer, 66:49-55, 1990.
19. Swedish Rectal Cancer Trial.: Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med, 336:980-987, 1997.
20. Pahiman L., Glimelius B.: Pre-or postoperative radiotherapy in rectal carcinoma: a report from a randomized multicenter trial. Ann Surg, 211:187-195, 1990.
21. Frykholm G., Glimelius B., Pahiman L.: Pre-or postoperative irradiation in adenocarcinoma of the rectum: Final treatment results of a randomized trial and an evaluation of late secondary effects. Dis Colon Rectum, 36:564-572, 1993.
22. Cedermark B., Johansson H., Rutquist L.E. et al.: The Stockholm I trial of preoperative short term radiotherapy in operable rectal carcinoma. Cancer, 75:2269-2275, 1995.
23. Stockholm Colorectal Cancer Study Group: Randomized study on preoperative radiotherapy in rectal carcinoma. Ann Surg Oncol, 3:423-430, 1996.
24. Gerard A., Buyse M., Nordlinger B. et al.: Preoperative radiotherapy as adjuvant treatment in rectal cancer. Ann Surg, 208:606-614, 1988.
25. Camma C, Giunta M., Fiorica F. et al.: Preoperative radiotherapy for resectable rectal cancer: A meta-analysis. JAMA, 284:1008-15, 2000.
26. Colorectal Cancer Collaborative Group: Adjuvant therapy for rectal cancer: a systematic overview of 22 randomised trials involving 8507 patients. Lancet, 2001 :In press.
27. Wagman R., Minsky B.D., Cohen A.M. et al.: Sphincter preservation in rectal cancer with preoperative radiation therapy and coloa-nal anastomis: long term follow-up. Int J Radiat Oncol Biol Phys, 42:51-57, 1998.
28. Francois Y., Nemoz C.J., Baulieux J. et al.: Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: the Lyon R90-0I randomized trial. J Clin Oncol, 17:2396-2402, 1999.
29. Rouanet P., Fabre J.M., Dubois J.B. et al.: Conservative surgery for low rectal carcinoma after high-dose radiation: Functional and oncologic results. Ann Surg, 221:67-73, 1995.
30. Hyams D.M., Masounas E.P., Petrelli N. et al.: A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum. A progress report of the National Surgical Adjuvant Breast and Bowel Project protocol RO-3. Dis Colon Rectum, 40:131-139, 1997.
31. Grann A., Minsky B.D., Cohen A.M. et al.: Preliminary results of preoperative 5-fluorouracil, low-dose Uucovorin, and concurrent radiation therapy for clinically resectable T3 rectal cancer. Dis Colon Rectum, 40:515-522, 1997.
32. Russell A.H., Harris J., Rosenberg P.J. et al.: Anal sphincter conservation for patients with adenocarcinoma of the distal rectum: long-term results of Radiation Therapy Oncology Group protocol 89-02. Int J Radiat Oncol Biol Phys, 46:313-22, 2000.
33. Valentini V., Coco C, Cellini N. et al.: Preoperative chemoradiation for extraperitoneal T3 rectal cancer: Acute toxicity, tumor response, and sphincter preservation. Int J Radiat Oncol Biol Phys, 40:1067-1075, 1998.
34. Valentini V., Coco C, Cellini N. et al.: Preoperative chemoradiation with cisplatin and 5-fluorouracil for extraperitoneal T3 rectal cancer: acute toxicity, tumor response, sphincter preservation. Int J Radiat Oncol Biol Phys, 45:1175-84, 1999.
35. Karanjia N.D., Schache D.J., North W.R.S. et al.: Close shavel in anterior resection. Br J Surg, 77:501-512, 1990.
36. Bujko K., Nowacki M.P., Oledzki J. et al.: Sphincter preservation afier short-term preoperative radiotherapy for low rectal cancer. Presentation of own data and a literature review. Acta Oncol, 2001, in press.
37. Swedish Rectal Cancer Trial: Preoperative irradiation followed by surgery vs surgery alone in resectable rectal carcinoma-postoperative morbidity and mortality in a Swedish multicenter trial. Br J Surg, 80:1333-1336, 1993.
38. Holm T., Rutqvist L.E., Johansson H. et al.: Postoperative mortality in rectal cancer treated with or without preoperative radiotherapy: causes and risk factors. Br J Surg, 83:964-968, 1996.
39. Holm T., Singnomklao T., Rutqvist L. et al.: Adjuvant preoperative radiotherapy in patients with rectal carcinoma. Adverse effects during long term follow-up of two randomized trials. Cancer, 78:968-976, 1996.
40. Bubrik M.P., Rolfmeyers E.S., Schauer R.M. et al.: Effects of high-dose and low-dose preoperative irradiation on low anterior anastomosis in dogs. Dis Colon Rectum, 25:406-415, 1982.
41. De Meerleer G., Pattyn P., Fortan L. et al.: High-dose preoperative radiotherapy does not alter the strength of unilaterally irradiated colon anastomoses in rats. Int J Radiat Oncol Biol Phys, 44:163-170, 1999.
42. Horn A., Halvorsen J.F., Dahl O.: Preoperative radiotherapy in operable rectal cancer. Dis Colon Rectum, 33:823-838, 1990.
43. Medical Research Council Rectal Cancer Working Party: Randomised trial of surgery alone versus radiotherapy followed by surgery for potentially operable locally advanced rectal cancer. Lancet, 348:1605-1610, 1996.
44. Frykholm-Jansson G., Sintorn K., Montelius A. et al.: Acute lumbosacral plexopathy after preoperative radiotherapy in rectal carcinoma. Radiother Oncol, 38:121-130, 1996.
45. Balslev I., Pedersen M., Teglbjaerg P.S. et al.: Postoperative radiotherapy in Dukes B and C carcinoma of rectum and rectosigmoid. Cancer, 58:22-28, 1986.
46. Gastrointestinal Tumor Study Group: Prolongation of the disease-free interval in surgically treated rectal carcinoma. New Engl J Med, 312:1464-1472, 1985.
47. Fisher B., Wolmark N., Rockette H. et al.: Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: Results from NSABP Protocol R-01. J Natl Cancer Inst, 80:21-29, 1988.
48. Miller R.C., Martenson J.A., Sargent D.J. et al.: Acute treatment-related diarrhea during postoperative adjuvant therapy for high-risk rectal carcinoma. Int J Radiat Oncol Biol Phys, 41:593-598, 1998.
49. Gunderson L.L., Russell A.H., Llewellyn H.J. et al.: Treatment planning for colorectal cancer: Radiation and surgical techniques and value of small-bowel films. Int J Radiat Oncol Biol Phys, 11:1379-1393, 1985.
50. Trimbos J.B., Snijders G., Keilhold T. et al.: Feasibility of application of a resorbable polyglycolic-acid mesh (Dexon mesh) to prevent complications of radiotherapy following gynecological surgery. Eur J Surg, 157:281-284, 1991.
51. Mak A.C., Rich T.A., Schultheiss T.E. et al.: Late complications of postoperative radiation therapy for cancer of the rectum and rectosigmoid. Int J Radiol Oncol Biol Phys, 28:597-603, 1994.
52. Dahlberg M.: Rectal cancer: Aspects of surgery and radiotherapy. Thesis. Uppsala, 1999.
53. Kollmorgcn C.F., Meagher A.P., Wolff B.G. et al.: The long-term effect of adjuvant postoperative chemoradiotherapy for rectal carcinoma on bowel junction. Ann Surg, 220:676-682, 1994.
54. Lewis W.G., Williamson M.E.R., Stephenson B.M. et al.: Potential disadvantages of postoperative adjuvant radiotherapy after anterior resection for rectal cancer: a pilot study of sphincter function, rectal capacity and clinical outcome. Int J Colorectal Disease, 10:133-137, 1995.
55. Lundby L., Jensen V.J., Overgaard J. et al.: Long-term colorectal function after postoperative radiotherapy for cohrectal cancer. Lancet, 350:564, 1997.
56. Dahlberg M., Glimelius B., Graf W. et al.: Preoperative irradiation affects the functional results after surgery for rectal cancer. Dis Colon Rectum, 41:543-549, 1998.
57. Gunderson L.L.: Indications for and results of combined modality treatment of colorectal cancer. Acta Oncol, 38:7-21, 1999.
58. Tveit K.M.: Radiotherapy in rectal cancer. Acta Oncol, 38:5-6, 1999.
59. Kapiteijn E., Kranenbarg E.K., Steup W.H. et al.: Total mesorectal excision (TME) with or without preoperative radiotherapy in the treatment of primary rectal cancer. Prospective randomised trial with standard operative and histopathological techniques. Dutch Colo Rectal Cancer Group. Eur J Surg, 165:410-20, 1999.
60. Withers H.R.: Biological aspects of conformal therapy. Acta Oncol, 39:569-77, 2000.
61. Tubiana M., Eschwege F.: Conformal radiotherapy and intensity-modulated radiotherapy-clinical data. Acta Oncol, 39:555-67, 2000.
62. Higgins G., Humphrey E., Dwight R. et al.: Preoperative radiation and surgery for cancer of the rectum. VASOG Trial II. Cancer, 58:352-359, 1986.
63. Roswit B., Higgins G., Keehn R.: Preoperative irradiation for carcinoma of the rectum and rectosigmoid colon: Report of a National Veterans Administration randomized study. Cancer, 35:1597-1602, 1975.
64. Kutzner J., Bruckner R, Kempf P.: Preoperative radiotherapy in rectal cancer. Strahlcnthcrapie, 160:236-8, 1984.
65. Reis Neto J.A., Quilici F.A., Reis Jr. J.A.: A comparison of nono-perative vs preoperative radiotherapy in rectal carcinoma. A 10-year randomized trial. Dis Colon Rectum, 32:702-710, 1989.
66. Medical Research Council Rectal Cancer Working Parry: Randomised trial of surgery alone versus surgery followed by radiotherapy for mobile cancer of the rectum. Lancet, 348:1610-1614, 1996.
67. Wolmark N., Wieand H.S., Hyams D.M. et al.: Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02. J Natl Cancer Inst, 92:388-96, 2000.
68. Arnaud J.P., Nordlinger B., Bossct J.F. et al.: Radical surgery and postoperative radiotherapy as combined treatment in rectal cancer. Final results of a phase 111 study of the European Organization for Research and Treatment of Cancer. Br J Surg, 84:352-357, 1997.
69. Treurniet-Donker A.D., W L J van Purten, Wereldsma J.C.J, et al.: Postoperative radiation therapy for rectal cancer. Cancer, 67:2042-2048, 1991.