Mechanisms of action of the anti-atherogenic effect of magnesium: Lessons from a mouse model

Magnesium Research

Volumn 14, Issue 3, 2001, Pages 173-179

  Sherer, Yaniv ^b   Bitzur, Rafael ^b   Cohen, Hofit ^b   Shaish, Aviv ^b   Varon, David ^b   Shoenfeld, Yehuda ^b   Harats, Dror ^a  

^a SHEBA MEDICAL CENTER   (Israel)

^b NONE

Author keywords

Atherosclerosis; LDL oxidation; Magnesium; Platelets; Retinol

Indexed keywords

ANTIBODY; ANTIOXIDANT; COPPER; DRUG DERIVATIVE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MAGNESIUM; OXIDIZED LOW DENSITY LIPOPROTEIN; RETINOL; RETINOL PALMITATE;

ANIMAL; ARTERIOSCLEROSIS; ARTICLE; ATHEROGENIC DIET; BLOOD; CHEMISTRY; DISEASE MODEL; FEMALE; GENETICS; HUMAN; IMMUNOLOGY; LIVER; MALE; METABOLISM; MOUSE; PATHOPHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES; ANTIOXIDANTS; ARTERIOSCLEROSIS; CHOLESTEROL, LDL; COPPER; DIET, ATHEROGENIC; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; LIPOPROTEINS, LDL; LIVER; MAGNESIUM; MALE; MICE; MICE, TRANSGENIC; RECEPTORS, LDL; VITAMIN A;

EID: 0035462708     PISSN: 09531424     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Ryan, M.F. (1991): The role of magnesium In clinical biochemistry: an overview. Ann. Clin. Biochem. 28, 19-26.
2. Whang, R. (1987): Routine serum magnesium determination - a continuing unrecognized need. Magnesium 6, 1-4.
3. Ouchi, Y., Tabata, R.E., Stergiopoulos, K. et al. (1990): Effect of dietary magnesium on development of atherosclerosis In cholesterol-fed rabbits. Arteriosclerosis 10, 732-737.
4. Altura, B.T., Brust, M., Bloom, S. et al (1990): Magnesium dietary intake modulates blood lipid levels and atherogenesis. Proc. Natl. Acad. Sci. USA 87, 1840-1844.
5. Sherer, Y., Shaish, A., Levkovitz, H. et al (1999): Magnesium fortification of drinking water suppresses atherogenesis in male LDL-receptor deficient mice. Pathobiology 67, 207-213.
6. Sherer, Y., Shoenfeld, Y., Shaish, A. et al (2000): Suppression of atherogenesis in female low-density lipoprotein-receptor knockout mice following magnesium fortification of drinking water: the importance of diet. Pathobiology 68, 93-98.
7. Ishibashi, S. et al (1993): Hypercholesterolemia in LDL receptor knockout mice and Its reversal by adenovirus mediated gene delivery. J. Clin. Invest. 92, 883-893.
8. Aviram, M. (1993): Macrophage-mediated oxidation of LDL and atherosclerosis. In: Free radicals, lipoprotein oxidation and atherosclerosis: biological and clinical aspects, Vol. IX, eds G. Bellomo, G. Finardi, C. Rice-Evans, pp. 101-137. London: Richelieu Press.
9. Esterbauer, H., Striegl, G., Puhl, P. & Rotheneder, M.F. (1989): Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic. Res. Commun. 6, 67-75.
10. Shaish, A., Ben-Amotz, A. & Avron, M. (1992): Biosynthesis of beta-carotene in Dunaliella. Methods. Enzymol 213, 439-444.
11. Varon, D., Dardik, R., Shenkman, B. et al (1997): A new method for quantitative analysis of whole blood platelet interaction with extracellular matrix under flow conditions. Thromb. Res. 85, 283-294.
12. Eisenberg, M.J. (1992): Magnesium deficiency and sudden death. Am. Heart. J. 124, 544-549.
13. Liao, F., Folsom, A.R. & Brancati, F.L. (1998): Is low magnesium concentration a risk factor for coronary heart disease? The Atherosclerosis Risk in Communities (ARIC) Study. Am. Heart. J. 136, 480-490.
14. Rayssiguier, Y., Gueux, E., Bussiere, L. et al. (1993): Dietary magnesium affects susceptibility of lipoproteins and tissues to peroxidation in rats. J. Am. Coll. Nutr. 12, 133-137.
15. Yamaguchi, Y., Kitagawa, S., Kunitomo, M. & Fujiwara, M. (1994): Preventive effects of magnesium on raised serum lipid peroxide levels and aortic cholesterol deposition in mice fed an atherogenic diet. Magnes. Res. 7, 31-37.
16. Bussiere, L., Mazur, A., Gueux, E. et al (1995): Triglyceride-rich lipoproteins from magnesium-deficient rats are more susceptible to oxidation by cells and promote proliferation of cultured vascular smooth muscle cells. Magnes. Res. 8, 151-157.
17. De Leeuw, I., Engelen, W., Aerts, P. & Schrans, S. (1998): Effect of intensive magnesium supplementation on the in vitro oxidizability of LDL and VLDL In Mg-depleted type 1 diabetic patients. Magnes. Res. 11, 179-182.
18. Maggi, E., Chiesa, R., Melissano, G. et al (1994): LDL oxidation in patients with severe carotid atherosclerosis: a study in vitro and in vivo oxidation markers. Arterioscler. Thromb. 14, 1892-1899.
19. Lehtimaki, T., Lehtinen, S., Solakivi, T. et al. (1999): Autoantibodies against oxidized low density lipoprotein in patients with angiographically verified coronary artery disease. Arterioscler. Thromb. Vase. Biol. 19, 23-27.
20. Bui, M.N., Sack, M.N., Moutsatsos, G. et al. (1996): Autoantibody titers to oxidized low-density lipoprotein in patients with coronary atherosclerosis. Am. Heart. J. 131, 663-667.
21. Salonen, J.T., Yla-Herttuala, S., Yamamoto, R. et al. (1992): Autoantibodies against oxidized LDL and progression of carotid atherosclerosis. Lancet 339, 883-887.
22. Wu, R., Nityanand, S., Berglund, L. et al. (1997): Antibodies against cardiolipin and oxidatively modified LDL in 50-year-old men predict myocardial infarction. Arterioscler. Thromb. Vase. Biol. 17, 3159-3163.
23. George, J., Afek, A., Gilburd, B. et al (1998): Hyperimmunization of apo-E mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis. Atherosclerosis 138, 147-152.
24. Ameli, S., Hultgardh-Nilsson, A., Regnstrom, J. et al. (1996): Effect of immunization with homologous LDL and oxidized LDL on early atherosclerosis in hypercholesterolemic rabbits. Arferioscler. Thromb. Vasc. Biol. 16, 1074-1079.
25. Sonoda, T., Ishizuka, T., Ishijima, S. et al. (1998): Rat liver phosphoribosylpyrophosphatase synthetase is activated by free Mg2+ in a manner that overcomes its inhibition by nucleotides. Biochim. Biophys. Acta. 1387, 32-40.
26. Gaussin, V., Hue, L., Stalmans, W. & Bollen, M. (1996): Activation of hepatic acetyl-CoA carboxylase by glutamate and Mg2+ is mediated by protein phosphatase-2A. Biochem. J. 316, 217-224.
27. Gunther, T., Vormann, J. & Hollriegl. V. (1995): Effects of magnesium and iron on lipid peroxidation in cultured hepatocytes. Mol. Cell. Biochem. 144, 141-145.
28. Palace, V.P., Khaper, N., Qin, Q. & Singal, P.K. (1999): Antioxidant potentials of vitamin A and carotenoids and their relevance to heart disease. Free. Radic. Biol. Med. 26, 746-761.
29. Alarcon, O.M., Burguera, J.L., Burguera, M. et al. (1994): Effects of acute overdose of vitamin A on the hepatic content of K, Na, Mg, Cu and Zn, in rats. Arch. Latinoam. Nutr. 44, 249-251.
30. Ravn, H.B., Kristensen, S.D., Vissinger, H. & Husted, S.E. (1996): Magnesium inhibits human platelets. Blood. Coagul. Fibrinolysis. 7, 241-244.
31. Gries, A., Bode, C., Gross, S. et al (1999): The effect of intravenously administered magnesium on platelet function in patients after cardiac surgery. Anesth. Analg. 88, 1213-1219.