The effect of intravenously administered magnesium on platelet function in patients after cardiac surgery

Anesthesia and Analgesia

Volumn 88, Issue 6, 1999, Pages 1213-1219

  Gries, André ^a   Bode, Christoph ^a   Gross, Stefanie ^a   Peter, Karlheinz ^a   Böhrer, Hubert ^a   Martin, Eike ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ASCORBATE MAGNESIUM; COLLAGEN; FIBRINOGEN; FIBRINOGEN RECEPTOR; MAGNESIUM ASPARTATE; MAGNESIUM SULFATE; MAGNESIUM VERLA; PADGEM PROTEIN; PLACEBO; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLEEDING TIME; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FLOW CYTOMETRY; HEART MUSCLE REVASCULARIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECEPTOR BINDING; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOCYTE RICH PLASMA;

EID: 0033065749     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199906000-00005     Document Type: Article

References (41)

1. Aglio LS, Stanford GG, Maddi R, et al. Hypomagnesemia is common following cardiac surgery. J Cardiothorac Vase Anesth 1991;5:201-8.
2. England MR, Gordon G, Salem M, Chernow B. Magnesium administration and dysrhythmias after cardiac surgery: a placebo-controlled, double blind, randomized trial. JAMA 1992; 268:2395-402.
3. Caspi J, Rudis E, Bar I, et al. Effects of magnesium on myocardial function after coronary artery bypass grafting. Ann Thorac Surg 1995;59:942-7.
4. Woods KL, Fletcher S, Roffe C, Haider Y. Intravenous magnesium sulphate in suspected acute myocardial infarction: results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet 1992;339:1553-8.
5. Hwang DL, Yen CF, Nadler JL. Effect of extracellular magnesium on platelet activation and intracellular calcium mobilization. Am J Hypertens 1992;5:700-6.
6. Fuentes A, Rojas A, Porter KB, et al. The effect of magnesium on bleeding time in pregnancy. Am J Obstet Gynecol 1995;173: 1246-9.
7. Ravn HB, Vissinger H, Kristensen SD, et al. Magnesium inhibits platelet activity: an infusion study in healthy volunteers. Thromb Haemost 1996;75:639-44.
8. Gawaz M, Ott I, Reininger AJ, Neumann FJ. Effects of magnesium on platelet aggregation and adhesion: magnesium modulates surface expression of glycoproteins on platelets in vitro and ex vivo. Thromb Haemost 1994;72:912-8.
9. Rinder CS, Bohnert J, Rinder HM, et al. Platelet activation and aggregation during cardiopulmonary bypass. Anesthesiology 1991;75:388-93.
10. Born GVR. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962;194:927-9.
11. Gries A, Bode C, Peter KH, et al. Inhaled nitric oxide inhibits human platelet aggregation, P-selectin expression, and fibrinogen binding in vitro and in vivo. Circulation 1998;97:1481-7.
12. Gibbs NM. The effects of anesthetics agents on platelet function. Anesth Intensive Care 1991;19:495-520.
13. Kratzer MAA, Born GVR. Simulation of primary hemostasis in vitro. Hemostasis 1985;15:357-62.
14. Mohr R, Goor DA, Lusky A, Lavee J. Aprotinin prevents cardiopulmonary bypass-induced platelet dysfunction: a scanning electron microscope study. Circulation 1992;86:II405-9.
15. Boldt J, Zickmann B, Czeke A, et al. Blood conservation techniques and platelet function in cardiac surgery. Anesthesiology 1991;75:426-32.
16. Boldt J, Schindler E, Osmer C, et al. Influence of different anticoagulation regimens on platelet function during cardiac surgery. Br J Anaesth 1994;73:639-44.
17. Wahba A, Koksch M, Rothe G, et al. Cardiopulmonary bypass leads to a preferential loss of activated platelets: a flow cytometric assay of platelet surface antigens. Eur J Cardiothorac Surg 1996;10:768-73.
18. Uthoff K, Zehr KJ, Geerling R, et al. Inhibition of platelet adhesion during cardiopulmonary bypass reduces postoperative bleeding. Circulation 1994;90:II269-74.
19. Satur CMR, Anderson JR, Jennings A, et al. Magnesium flux caused by coronary artery bypass operation: three patterns of deficiency. Ann Thorac Surg 1994;58:1674-8.
20. Ravn HB, Vissinger H, Kristensen SD, Husted SE. Magnesium inhibits platelet activity: an in vitro study. Thromb Haemost 1996;76:88-93.
21. 2+. Semin Thromb Hemost 1995;21:137-45.
22. Kynczl-Leisure M, Cibils LA. Increased bleeding time after magnesium sulfate infusion. Am J Obstet Gynecol 1996;175:1293-4.
23. Atar D, Serebruany V, Poulton J, et al. Effects of magnesium supplementation in a porcine model of myocardial ischemia and reperfusion. J Cardiovasc Pharmacol 1994;24:603-11.
24. Serebruany VL, Herzog WR, Schlossberg ML, Gurbel PA. Bolus magnesium infusion in humans is associated with predominantly unfavourable changes in platelet aggregation and certain haemostatic factors. Pharmacol Res 1997;36:17-22.
25. Loscalzo J. Antiplatelet and antithrombotic effects of organic nitrates. Am J Cardiol 1992;70:18B-22B.
26. Hardy E, Glenn J, Heptinstall S, et al. Magnesium modifies the responses of platelets to inhibitory agents which act via cAMP. Thromb Haemost 1995;74:1132-7.
27. Pearson PJ, Evora PRB, Seccombe JF, Schaff HV. Hypomagnesemia inhibits nitric oxide release from coronary endothelium: protective role of magnesium infusion after cardiac operations. Ann Thorac Surg 1998;65:967-72.
28. ISIS 4 Collaborative Group. ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. Lancet 1995;345:669-85.
29. Parikka H, Toivonen L, Pellinen T, et al. The influence of intravenous magnesium sulphate on the occurrence of atrial fibrillation after coronary artery bypass operation. Eur Heart J 1993; 14:251-8.
30. Knopes KD, Hecker BR. Con: magnesium is not a valuable therapy in the cardiac surgical patient. J Cardiothor Vase Anesth 1991;5:522-4.
31. Aupetit JF, Freysz M, Faucon G, et al. Magnesium: a profibrillatory or antifibrillatory drug depending on plasma concentration, heart rate and myocardial perfusion. Acta Anaesthesiol Scand 1997;41:516-23.
32. Lehr HA, Weyrich AS, Saetzler RK, et al. Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking. J Clin Invest 1997;99:2358-64.
33. Gaziano JM. Antioxidant vitamins and coronary artery disease risk. Am J Med 1994;97:18S-21S.
34. Salonen JT, Salonen R, Seppanen K, et al. Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo controlled, double-blind trial in men with low antioxidant status. Am J Clin Nutr 1991;53:1222-9.
35. Jourdan A, Aguejouf O, Imbault P, et al. Experimental thrombosis model induced by free radicals: application to aspirin and other different substances. Thromb Res 1995;79:109-23.
36. Calzada C, Bruckdorfer KR, Rice-Evans CA. The influence of antioxidant nutrients on platelet function in healthy volunteers. Atherosclerosis 1997;128:97-105.
37. Greilich PE, Carr ME Jr, Carr SL, Chang AS. Reduction in platelet force development by cardiopulmonary bypass are associated with hemorrhage. Anesth Analg 1995;80:459-65.
38. Ray MJ, Marsh NA, Just SJ, et al. Preoperative platelet dysfunction increases the benefit of aprotinin in cardiopulmonary bypass. Ann Thorac Surg 1997;63:57-63.
39. Hobbs WJC, Fitchet A, Cotter L. Atrial arrhythmias after cardiac surgery [letter]. N Engl J Med 1997;337:860-1.
40. Hamill-Ruth RJ, McGory R. Magnesium repletion and its effect on potassium hemostasis in critically ill adults: results of a double-blind, randomized, controlled tral. Crit Care Med 1996; 24:38-45.
41. Puri GD, Marudhachalam KS, Chari P, Suri RK. The effect of magnesium sulphate on hemodynamics and its efficacy in attenuating the response to endotracheal intubation in patients with coronary artery disease. Anesth Analg 1998;87:808-11.