Effect of intensive magnesium supplementation on the in vitro oxidizability of LDL and VLDL in Mg-depleted type 1 diabetic patients

Magnesium Research

Volumn 11, Issue 3, 1998, Pages 179-182

  De Leeuw, I ^a   Engelen, W ^a   Aerts, P ^a   Schrans, S ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Lipid peroxidation; Mg depletion; Mg supplementation; Type 1 diabetes

Indexed keywords

LOW DENSITY LIPOPROTEIN; MAGNESIUM; THIOBARBITURIC ACID REACTIVE SUBSTANCE; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; BLOOD; CLINICAL TRIAL; DIET SUPPLEMENTATION; DRUG EFFECT; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; OXIDATION REDUCTION REACTION;

DIABETES MELLITUS, TYPE 1; DIETARY SUPPLEMENTS; HUMANS; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; MAGNESIUM; OXIDATION-REDUCTION; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0032151960     PISSN: 09531424     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Bierman,E.L. (1992): Atherogenesis in diabetes. Arterioscler. Thromb. 12, 647-656.
2. Ginsberg, H.N. (1991): Lipoprotein physiology in nondiabetic and diabetic states. Relationship to atherogenesis. Diabetes Care 14, 839-855.
3. Fujii, S., Takemura ,T., Wada, M., Akai, T. & Okuda, K. (1982): Magnesium levels in plasma, erythrocyte and urine in patients with diabetes mellitus. Horm. Metab. Res. 14, 161-162.
4. Sjögren, A., Floren, C.H. & Nilson, A. (1986): Magnesium deficiency in IDDM is related to the level of glycosylated hemoglobin. Diabetes 35, 459-463.
5. De Leeuw, I., Vertommen, J. & Abs R. (1978): The magnesium content of the trabecular bone in diabetic subjects. Biomedicine 29, 16-17.
6. Durlach, J. (1985): Les modes d'exploration du magnesium. In: Le magnesium en pratique clinique, ed. L. Durlach, pp. 45-68. Paris: J.B. Baillière.
7. Rayssiguier, Y., Gueux, E. & Weiser, D. (1981): Effect of magnesium deficiency on lipid metabolism in rats fed a high carbohydrate diet. J. Nutr . 11, 1876-1883.
8. Haber, A. B., Kofoed-Enevoldsen, A. & Jensen, T. (1992): The prevalence of hypercholesterolaemia and its relationship with albuminuria in IDDM: an epidemiologic study. Diabet. Med. 9, 557-561.
9. De Leeuw, I. (1994): Is Mg supplementation useful in the prevention of atherosclerosis in insulin-dependent diabetic patients? Magnes. Res. 7, (suppl 1), 22.
10. Gueux, E., Mazur, A., Cardot, P. & Rayssiguier, Y. (1991): Magnesium deficiency affects the plasma lipoprotein composition in rats. J. Nutr. 12, 1222-1227.
11. Gueux, E., Cubizolles, C., Bussière, L., Mazur, A. & Rayssiguier, Y. (1993): Oxidative modification of triglyceride-rich lipoproteins in hypertriglyceridemic rats following magnesium deficiency. Lipids 28, 573-575.
12. Baynes J., W (1991): Role of oxidative stress in the development of complications in diabetes. Diabetes 40, 405-412.
13. De Leeuw, I., Van Gaal, L., Vertommen, J. & Zhang. A. (1995): Low erythrocyte magnesium is associated with increased oxidizability of LDL and VLDL in insulin-dependent diabetic patients. Diabetologia 38, (suppl 1), A246, nr 952.
14. De Leeuw, I., Engelen, W., Vertommen, J. & Nonneman, L. (1997): Effect of intensive IV+ oral magnesium supplementation on circulating ion levels, lipid parameters and metabolic control in Mg-depleted insulin-dependent diabetic patients. Magnes. Res. 10, 135-141.
15. Altura, B.T., Shirey, T.L., Young, C.C., Dell'Orfano, K., Hiti. J., Welsh, R., Yeh, Q., Barbour, R.L. & Altura, B.M. (1994): Characterization of a new ion selective electrode for ionized magnesium in whole blood, plasma, serum and aqueous samples. Scand. J. Clin. Lab. Invest. 54, (suppl. 217), 21-36.
16. Zhang, A., Vertommen, J., Van Gaal, L. & De Leeuw, I. (1994): A rapid and simple method for measuring the susceptibilty of LDL and VLDL to copper-catalyzed oxidation. Clin. Chim. Acta 227, 159-173.
17. De Leeuw, I., Van Gaal, L. & Zhang, A. (1996): Effects of lipid lowering drugs on the in vitro oxidizability of lipoproteins in diabetes. In: Drugs affecting lipid metabolism, ed. A.M. Gotto, R. Paoletti, L.L. Smith, A.L. Catapano, A.S. Jackson, pp. 69-75. Dordrecht: Kluwer Acedemic Publishers.
18. Rayssiguier, Y., Gueux, E , Bussière, L., Durlach, J. & Mazur, A. (1993): Dietary magnesium affects susceptibilty of lipoproteins and tissues to peroxidation in rats. J. Am. Coll. Nutr. 12, 133-137.
19. Yamaguchi, Y., Kitaguwa, S., Kunitomo, M. & Fujiwara, M. (1994). Preventive effects of magnesium on raised serum lipid peroxide levels and aortic cholesterol deposition in mice fed on atherogenic diet. Magnes. Res. 7, 31-37.
20. Djurhuus, M.S., Skott, P. & Hother-Nielsen, O. (1995). Insulin increases renal Mg excretion: a possible cause of Mg depletion in hyperinsulinaemic states. Diabet. Med. 12, 664-669.
21. Hunt, S.V., Dean, R.T. & Wok, S.P. (1988). Hydroxyl radical production and autoxidative glycosylation. Biochem. J. 256, 205-212.