Abnormal Glucose Handling by the Kidney in Response to Hypoglycemia in Type 1 Diabetes

Diabetes

Volumn 50, Issue 9, 2001, Pages 2087-2093

  Cersosimo, Eugenio ^a,b   Garlick, Peter ^a   Ferretti, John ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b Texas Diabetes Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; FATTY ACID; GLUCOSE; GLYCEROL; HORMONE; NORADRENALIN;

ADULT; ARTICLE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY; KINETICS; MALE; METABOLISM; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL;

ADULT; DIABETES MELLITUS, TYPE 1; EPINEPHRINE; FATTY ACIDS, NONESTERIFIED; FEMALE; GLUCOSE; GLYCEROL; HORMONES; HUMANS; HYPOGLYCEMIA; KIDNEY; KINETICS; MALE; MIDDLE AGED; NOREPINEPHRINE;

EID: 0035462587     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.9.2087     Document Type: Article

References (35)

1. The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329:977-986, 1993
2. Cryer PE: Hypoglycemia: the limiting factor in the management of IDDM. Diabetes 43:1378-1389, 1994
3. Fischer KF, Lees JA, Newman JH: Hypoglycemia in hospitalized patients. N Engl J Med 315:1245-1250, 1986
4. Cahill GF Jr, Herrera MG, Morgan AP, Soeldner JS, Steinke J, Levy PL, Reichard GA Jr, Kipnis DM: Hormone-fuel interrelationships during fasting. J Clin Invest 45:1751-1769, 1966
5. Owen OE, Felig P, Morgan AP, Wahren J, Cahill GF Jr: Liver and kidney metabolism during prolonged starvation. J Clin Invest 48:574-588, 1969
6. Cahill GF Jr: Starvation in man. N Engl J Med 282:668-675, 1970
7. Cersosimo E, Judd RL, Miles JM: Insulin regulation of renal glucose metabolism in conscious dogs. J Clin Invest 93:2584-2589, 1994
8. Stumvoll M, Chintalapudi U, Perriello G, Welle S, Gutierrez O, Gerich J: Uptake and release of glucose by the human kidney: postabsorptive rates and responses to epinephrine. J Clin Invest 96:2528-2533, 1995
9. Cersosimo E, Garlick P, Ferretti J: Insulin regulation of renal glucose metabolism in humans. Am J Physiol 276:E78-E84, 1999
10. Ekberg K, Landau BR, Wajngot A, Chandramouli V, Efendic S, Brunengraber H, Wahren J: Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting. Diabetes 48:292-298, 1999
11. Cersosimo E, Garlick P, Ferretti J: Renal glucose production during insulin-induced hypoglycemia in humans. Diabetes 48:261-266, 1999
12. Meyer C, Dostou JM, Gerich JE: Role of human kidney in glucose counterregulation. Diabetes 48:943-948, 1999
13. Lecavalier L, Bolli G, Cryer PE, Gerich JE: Contributions of gluconeogenesis and glycogenolysis during glucose counterregulation in normal humans. Am J Physiol 256:E844-E851, 1989
14. Gerich JE, Langlois M, Noacco C, Karam J, Forsham P: Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha-cell defect. Science 182:171-173, 1973
15. Dagogo-Jack SE, Craft S, Cryer PE: Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. J Clin Invest 91:819-828, 1993
16. Simonson DC, Tamborlane WV, DeFronzo RA, Sherwin RS: Intensive insulin therapy reduces counterregulatory responses to hypoglycemia in patients with type I diabetes. Ann Intern Med 103:184-190, 1985
17. Butler PC, Cuomo A, Zerman A, O'Brien PC, Cobelli C, Rizza RA: Methods of assessment of the rate of onset and offset of insulin action during nonsteady state in humans. Am J Physiol 27:E548-E560, 1993
18. Lloyd B, Burrin P, Smythe P, Alberti KGGM: Enzymatic fluorometric continuous flow assays for blood glucose, lactate, pyruvate, alanine, glycerol and 3-hydroxybutyrate. Clin Chem 24:1724-1729, 1978
19. Brun C: A rapid method for the determination of para-amino-hippurate acid in kidney function tests. J Lab Clin Med 37:955-958, 1951
20. Herbert V, Lau K, Gottlieb CW, Bleicher SJ: Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 25:1375-1384, 1965
21. Heiding L: Radioimmunological determination of human C-peptide in serum. Diabetologia 11:541-548, 1975
22. Aguillar-Parada E, Eisentraut AM, Unger UH: Pancreatic glucagon secretion in normal and diabetic subjects. Am J Med Sci 257:415-419, 1969
23. Zaitseva I, Ajmal M, Cersosimo E: Application of high-performance liquid chromatography of plasma fatty acids as their phenacyl esters to evaluate splanchnic and renal fatty acid balance in vivo. J Chromatogr B Biomed Sci Appl 727:15-22, 1999
24. Cryer PE, Santiago J, Shah D: Measurement of norepinephrine and epinephrine in small volumes of human plasma by a single isotope derivative method: response to the upright posture. J Endocrinol Metab 39: 1025-1029, 1974
25. Bolli G, de Feo P, Compagnucci P, Cartechini MG, Angeletti G, Santeusanio F, Brunetti P, Gerich JE: Abnormal glucose counterregulation in insulin-dependent diabetes mellitus: interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion. Diabetes 32:134-141, 1983
26. Wiethop BV, Cryer PE: Alanine and terbutaline in the treatment of hypoglycemia in IDDM. Diabetes Care 16:1131-1136, 1993
27. Veneman T, Mitrakou A, Mokan M, Cryer PE, Gerich JE: Induction of hypoglycemia unawareness by asymptomatic nocturnal hypoglycemia. Diabetis 42:1233-1237, 1993
28. Amiel SA, Tamborlane WV, Simonson DC, Sherwin RS: Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus. N Engl J Med 316:1376-1383, 1987
29. Moller N, Rizza RA, Ford GC, Nair KS: Assessment of postabsorptive renal glucose metabolism in humans with multiple glucose tracers. Diabetes 50:747-751, 2001
30. Meyer C, Stumvoll M, Nadkarni V, Dostou J, Mitrakou A, Gerich J: Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus. J Clin Invest 102:619-624, 1998
31. Joseph SE, Heaton N, Potter D, Pernet A, Umpleby MA, Amiel S: Renal glucose production compensates for the liver during the anhepatic phase of liver transplantation. Diabetes 49:450-456, 2000
32. Maggs DG, Jacob R, Rife F, Caprio S, Tamborlane WV, Sherwin RS: Counterregulation in peripheral tissues: effects of systemic hypoglycemia on levels of substrates and catecholamines in human skeletal muscle and adipose tissue. Diabetes 46:70-76, 1997
33. Davis SN, Fowler S, Costa F: Hypoglycemic counterregulatory responses differ between men and women with type 1 diabetes. Diabetes 49:65-72, 2000
34. Dagogo-Jack SE, Rattarasarn C, Cryer PE: Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM. Diabetes 43:1426-1434, 1999
35. Axelsen M, Wesslau C, Lonnroth P, Smith U: Reduced frequency of nocturnal hypoglycemia by bedtime cornstarch supplement in IDDM subjects (Abstract). Diabetologia 39:A219, 1996