Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM

Diabetes

Volumn 43, Issue 12, 1994, Pages 1426-1434

  Dagogo Jack, Samuel ^b   Rattarasarn, Chatchalit ^b   Cryer, Philip E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; GLUCAGON; HYDROCORTISONE; INSULIN; PANCREAS POLYPEPTIDE;

ADRENAL MEDULLA; ADULT; ARTICLE; AWARENESS; CHOLINERGIC TRANSMISSION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HORMONE BLOOD LEVEL; HORMONE RESPONSE; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; MALE; NEUROENDOCRINE SYSTEM; PRIORITY JOURNAL;

EID: 0028608981     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.43.12.1426     Document Type: Article

References (18)

1. Pramming S, Thorsteinsson B, Bendtson I, Binder C: Symptomatic hypoglycemia in 411 type I diabetic patients. Diabetic Med 8:217-222, 1991
2. Cryer PE: Iatrogenic hypoglycemia in IDDM: consequences, risk factors and prevention. In Diabetes Annual. Vol. 7. Home PD, Marshall S, Alberti KGMM, Krall L, Eds. Amsterdam, Elsevier, 1993, p. 317-331
3. Heller SR, Herbert M, Macdonald IA, Tattersall KB: Influence of sympathetic nervous system on hypoglycaemic warning symptoms. Lancet ii:359-303, 1987
4. Hepbum DA, Patrick AW, Eadington DW, Ewing DJ, Frier BM: Unawareness of hypoglycaemia in insulin-treated diabetic patients: prevalence and relationship to autonomic neuropathy. Diabetic Med 7:711-717, 1990
5. Ryder REJ, Owens DR, Hayes TM, Ghatei M, Bloom SR: Unawareness of hypoglycemia and inadequate glucose counterregulation: no causal relationship with diabetic autonomic neuropathy. Br Med J 301:783-787, 1990
6. Grimaldi A, Bosquet F, Davidoff P, Digy JP, Sachon L, Landault C, Thervet F, Zoglibi F, Legrand JC: Unawareness of hypoglycemia by insulin-dependent diabetics. Horm Metab Res 22:90-95, 1990
7. Clarke WL, Gonder-Frederick LA, Richards FE, Cryer PE: Multifactorial origin of hypoglycemic symptom Unawareness in insulin-dependent diabetes mellitus. Diabetes 40:680-685, 1991
8. Hepburn DA, Patrick AW, Brash H-M, Thomson I, Frier BM: Hypoglycemia unawareness in type I diabetes: a lower plasma glucose is required to stimulate sympathoadrenal activation. Diabetic Med 8:934-945, 1991
9. White NH, Skor DA, Cryer PE, Levandoski L, Santiago JV: Identification of type 1 diabetic patients at increased risk for hypoglycemia during intensive therapy. N Engl J Med 308:485-191, 1983
10. Bolli GB, De Feo P, De Cosmo S, Perriello G, Ventura MM, Massi-Benedetti M, Santeusanio F, Gerich JE, Brunetti P: A reliable and reproducible test for adequate glucose counterregulation in type I diabetes mellitus. Diabetes 33:732-737, 1984
11. Sjöbom NC, Adamson U, Lins PE: The prevalence of impaired glucose counterregulation during an insulin infusion test in insulin treated patients prone to severe hypoglycemia. Diabetologia 32:818-825, 1989
12. Amiel SA, Tamborlane WV, Simonson DC, Sherwin RS: Defective glucose counterregulation after strict control of insulin-dependent diabetes mellitus. N Engl J Med 316:1376-1383, 1987
13. Amiel SA, Sherwin RS, Simonson DC, Tamborlane WV: Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release. Diabetes 37:901-907, 1988
14. Boyle PJ, Schwartz NS, Shah SD, Clutter WE, Cryer PE: Plasma glucose concentrations at the onset of hypoglycemic symptoms in patients with poorly controlled diabetes and in nondiabetics. N Engl J Med 318:1487-1492, 1988
15. Heller SR, Cryer PE: Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after one episode of hypoglycemia in nondiabetic humans. Diabetes 40:223-226, 1991
16. Davis M, Shamoon H: Counterregulatory adaptation to recurrent hypoglycemia in normal humans. J Clin Endocrinol Afetab 73:995-1001, 1991
17. Widom B, Simonson DC: Intermittent hypoglycemia impairs glucose counterregulation. Diabetes 41:1597-1602, 1992
18. Cryer PE: Iatrogenic hypoglycemia as a cause of hypoglycemia-associated autonomic failure in IDDM: a vicious cycle. Diabetes 41:255-260, 1992