Gene silencing: Double-stranded RNA mediated mRNA degradation and gene inactivation

Cell Research

Volumn 11, Issue 3, 2001, Pages 181-186

  Tang, Wei ^a   Luo, Xiao Yan ^b   Sanmuels, Vanessa ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Double stranded RNA; Gene silencing; Homologous RNA; Methylation; Transgene

Indexed keywords

DOUBLE STRANDED RNA; MESSENGER RNA; VIRUS PROTEIN;

ANIMAL; GENE; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; METHYLATION; REVIEW; RNA PROCESSING; TRANSGENE;

ANIMALS; GENE SILENCING; GENES, PLANT; METHYLATION; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, DOUBLE-STRANDED; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSGENES; VIRAL PROTEINS;

EID: 0035459763     PISSN: 10010602     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cr.7290084     Document Type: Review

References (46)

1. Fagard M, Vaucheret H. (Trans) gene silencing in plants: how many mechanisms? Annual Review of Plant Physiology and Plant Molecular Biology 2000; 51:167-94.
2. Ding SW. RNA silencing. Current Opinion of Biotechnology 2000; 11:152-6.
3. Faugeron G. Diversity of homology-dependent gene silencing strategies in fungi. Current Opinion of Microbiology 2000; 3:144-8.
4. Birchler JA, Pal Bhadra M, Bhadra U. Making noise about silence: repression of repeated genes in animals. Current Opinion of Genetic and Development 2000; 10:211-6.
5. Cogoni C, Macino G. Post-transcriptional gene silencing across kingdoms. Current Opinion of Genetic and Development 2000; 10:638-43.
6. Wassenegger M. RNA-directed DNA methylation. Plant Molecular Biology 2000; 43:203-20.
7. Matzke MA, Mette MF, Matzke AJM. Transgene silencing by the host genome defense: implications for the evolution of epigenetic control mechanisms in plants and vertebrates. Plant Molecular Biology 2000; 43:401-15.
8. Hamilton A, Baulcombe DC. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 1999; 286:950-2.
9. Bass B. Double-stranded RNA as a template for gene silencing. Cell 2000; 101:235-8.
10. Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: dsRNA directs the ATP-dependent cleavage of mRNA at 21-23 nt intervals. Cell 2000; 101:25-33.
11. Fagard M, Vaucheret H. Systemic silencing signal(s). Plant Molecular Biology 2000; 43:285-93.
12. Smardon A, Spoerke J, Stacey S, Klein M, Mackin N, Maine E. EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans. Current Biology 2000; 10:169-78.
13. Llave C, Kasschau KD, Carrington JC. Virus encoded suppressor of posttranscriptional gene silencing targets a maintenance step in the silencing pathway. Proceedings of National Academy of Sciences of the United States of America 2000; 97:13401-6.
14. Anandalakshmi R, Marathe R, Ge X, Herr JM Jr, Mau C, Mallory A, Pruss G, Bowman L, Vance VB. A calmodulin-related protein that suppresses posttranscriptional gene silencing in plants. Science 2000; 290:142-4.
15. Hammond S, Bernstein E, Beach D, Hannon G. An RNA-directed nuclease mediates PTGS in Drosophila cells. Nature 2000; 404:293-6.
16. Yang D, Lu H, Erickson JW. Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos. Current Biology 2000; 10:1191-200.
17. Voinnet O, Lederer C, Baulcombe D. A viral movement protein prevents spread of the gene silencing signal in Nicotiana benthamiana. Cell 2000; 103:157-67.
18. Kovarik A, Van Houdt H, Holy A, Depicker A. Drug-induced hypomethylation of a postranscriptionally silenced transgene locus of tobacco leads to partial release of silencing. FEBS Letter 2000; 467:47-51.
19. Elmayan T, Balzergue S, Béon F, Bourdon V, Daubremet J, Guénet Y, Mourrain P, Palauqui JC, Vernhettes S, Vialle T. Arabidopsis mutants impaired in co-suppression. Plant Cell 1998; 10:1447-57.
20. Fagard M, Boutet S, Morel JB, Bellini C, Vaucheret H. AGO-1, QDE-2 and RDE-1 are related proteins required for PTGS in plants, quelling in fungi and RNAi in animals. Proceedings of National Academy of Sciences of the United States of America 2000; 97:11650-4.
21. Mourrain P, Béclin C, Elmayan T, Feuerbach F, Godon C, Morel J-B, Jouette D, Lacombe A-M, Nikic S, Picault N. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance. Cell 2000; 101:533-42.
22. Hirochika H, Okamoto H, Kakutani T. Silencing of retro-transposons in Arabidopsis and reactivation by the ddm1 mutation. Plant Cell 2000; 12:357-68.
23. Wassenegger M, Heimes S, Riedel L, S?nger H. RNA-directed de novo methylation of genomic sequences in plants. Cell 1994; 76:567-76.
24. Jones AL, Thomas CL, Maule AJ. De novo methylation and cosuppression induced by a cytoplasmically replicating plant RNA virus. EMBO Journal 1998; 17:6385-93.
25. Jones L, Hamilton AJ, Voinnet O, Thomas CL, Maule AJ, Baulcombe DC: RNA-DNA interactions and DNA methylation in post-transcriptional gene silencing. Plant Cell 1999; 11:2291-301.
26. Mette MF, van der Winden J, Matzke MA, Matzke AJM. Production of aberrant promoter transcripts contributes to methylation and silencing of unlinked homologous promoters in trans. EMBO Journal 1999; 18:241-8.
27. Pélissier T, Thalmair S, Kempe D Sänger HL, Wassenegger M. Heavy de novo methylation at symmetrical and non-symmetrical sites is a hallmark of RNA-directed DNA methylation. Nucleic Acids Research 1999; 27:1625-43.
28. Pélisser T, Wassenegger M. A DNA target of 30 bp is sufficient for RNA-directed DNA methylation. RNA 2000; 6:55-65.
29. Voinnet O, Pinto Y, Baulcombe D. Suppression of gene silencing: a general strategy used by diverse DNA and RNA viruses of plants. Proceedings of National Academy of Sciences of the United States of America 1999; 96:14147-52.
30. Brigneti G, Voinnet O, Li WX, Ji LH, Ding SW, Baulcombe DC. Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana. EMBO Journal 1998; 7:6739-46.
31. Mette MF, Aufsatz W, van der Winden J, Matzke MA, Matzke AJM. Transcriptional gene silencing and promoter methylation triggered by double stranded RNA. EMBO Journal 2000; 19:5194-201.
32. Lucy A, Guo H, Li W, Ding S. Suppression of posttranscriptional gene silencing by a plant viral protein localized in the nucleus. EMBO Journal 2000; 19:1672-80.
33. Wu-Scharf D, Jeong B, Zhang C, Cerrutti H. Transgene and transposon silencing in Chlamydomonas reinhardtii by a DEAH-box RNA helicase. Science 2000; 290:1159-63.
34. Chuang CF, Meyerowitz EM. Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana. Proceedings of National Academy of Sciences of the United States of America 2000; 97:4985-90.
35. Smith NA, Singh SP, Wang MB, Stoutjesdijk PA, Green AG, Waterhouse PM. Total silencing by intron-spliced hairpin RNAs. Nature 2000; 407:319-20.
36. Waterhouse PM, Graham MW, Wang MB. Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA. Proceedings of National Academy of Sciences of the United States of America 1998; 95:13959-64.
37. Metzlaff M, O'Dell M, Hellens R, Flavell R. Developmentally and transgene regulated nuclear processing of primary transcripts of chalcone synthase A in petunia. Plant Journal 2000; 23:63-72.
38. Stam M, de Bruin R, van Blokland R, van der Hoorn RAL, Mol JNM, Kooter JM. Distinct features of posttranscriptional gene silencing by antisense transgenes in single copy and inverted T-DNA repeat loci. Plant Journal 2000; 21:27-42.
39. Van Houdt H, Van Montagu M, Depicker A. Both sense and antisense RNAs are targets for the sense transgeneinduced posttranscriptional silencing mechanisms. Molecular and General Genetics 2000; 263:995-1002.
40. Cogoni C, Macino G. Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase. Nature 1999; 399:166-9.
41. Dalmay T, Hamilton A, Rudd S, Angell S, Baulcombe D. An RNA dependent RNA polymerase gene in Arabidopsis is required for PTGS mediated by a transgene but not by a virus. Cell 2000; 101:543-53.
42. Catalanotto C, Azzalin G, Macino G, Cogoni C. Gene silencing in worms and fungi. Nature 2000; 404:245.
43. Tabara H, Sarkissian M, Kelly WG, Fleenor J, Grishok A, Timmons L, Fire A, Mello CC. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell 1999; 99:123-32.
44. Cogoni C, Macino G. Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase. Science 1999; 286:2342-4.
45. Ketting RF, Haverkamp TH, van Luenen HG, Plasterk RH: Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD. Cell 1999; 99:133-41.
46. Domeier ME, Morse DP, Knight SW, Portereiko M, Bass BL, Mango SE. A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans. Science 2000; 289:1928-30.