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Brunner-La Rocca HP, Sutsch G, Schneider J, Follath F, Kiowski W: Natural course of moderate cardiac allograft rejection (International Society for Heart Transplantation grade 2) early and late after transplantation. Circulation 1996, 94:1334-1338. Multivariate analysis of over 300 biopsies showed that the strongest predictor of grade 3A or greater rejection was grade 2 rejection on the previous biopsy. A strong inverse correlation between graft rejection and time interval after transplantation was demonstrated.
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Hausen B, Ronde R, Demertzis S, Albes JM, Wahlers T, Schafers HJ: Strategies for routine biopsies in heart transplantation based on 8-year results with more than 13,000 biopsies. Eur J Cardiothorac Surg 1995, 9:592-598.
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49
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Routine surveillance myocardial biopsies are unnecessary beyond one year after heart transplantation
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White JA, Guiraudon C, Pflugfelder PW, Kostuk WJ: Routine surveillance myocardial biopsies are unnecessary beyond one year after heart transplantation. J Heart Lung Transplant 1995, 14:1052-1056. A study of over 1000 endomyocardial biopsies performed 1 to 12 years after transplantation found that, because rejection is rare beyond 1 year after transplantation, routine surveillance biopsies performed beyond 1 year do not significantly impact patient management.
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Sethi GK, Kosaraju S, Arabia FA, Roasdo LJ, McCarthy MS, Copeland JG: Is it necessary to perform surveillance endomyocardial biopsies in heart transplant recipients? J Heart Lung Transplant 1995, 14:1047-1051. A retrospective study comparing patients who had surveillance biopsies performed beyond 6 months after transplantation with those who did not. Because no difference was found in actuarial survival rate or freedom from late rejection, the authors concluded that routine surveillance biospies beyond 6 months are not necessary.
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Balzer DT, Moorhead S, Saffitz JE, Huddleston CB, Spray TL, Canter CE: Utility of surveillance biopsies in infant heart transplant recipients. J Heart Lung Transplant 1995, 14:1095-1101. A study in pediatric heart transplant recipients that showed surveillance biopsies beyond 6 months after transplantation rarely yielded positive results.
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Fisher PE, Suciu-Foca N, Ho E, Michler RE, Rose EA, Mancini D: Additive value of immunologic monitoring to histologic grading of heart allograft biopsy specimens: implications for therapy. J Heart Lung Transplant 1995, 14:1156-1161.
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Smith JD, Rose ML, Pomerance A, Burke M, Yacoub MH: Reduction of cellular rejection and increase in longer-term survival after heart transplantation after HLA-DR matching. Lancet 1995, 346:1318-1322. Study relating HLA-DR mismatching to number of rejection episodes and graft survival.
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Anderson JR, Hossein-Nia M, Brown PA, Corbishley C, Murday AJ, Holt DW: Creatine kinase MB isoforms: a potential predictor of acute cardiac allograft rejection. J Heart Lung Transplant 1995, 14:666-670.
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Frequency of hypoxanthine guanine phosphoribosyltransferase (HPRT) T cells in the peripheral blood of cardiac transplant recipients: A noninvasive technique for the diagnosis of allograft rejection
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Ansari AA, Mayne A, Sundstrom JB, Gravanis MB, Kanter K, Sell KW, Villinger F, Siu CO, Herskowitz A: Frequency of hypoxanthine guanine phosphoribosyltransferase (HPRT) T cells in the peripheral blood of cardiac transplant recipients: a noninvasive technique for the diagnosis of allograft rejection. Circulation 1995, 92:862-874.
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59
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Lagoo AS, George JF, Naftel DC, Griffin AK, Kirklin JK, Lagoo-Deenadayalan S, Hardy KJ, Savunen T, McGiffin DC: Semiquantitative measurement of cytokine messenger RNA in endomyocardium and peripheral blood mononuclear cells from human heart transplant recipients. J Heart Lung Transplant 1996, 15:206-217.
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J Heart Lung Transplant
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Lagoo, A.S.1
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