Development of an effective gene delivery system: A study of complexes composed of a peptide-based amphiphilic DNA compaction agent and phospholipid

Nucleic Acids Research

Volumn 29, Issue 17, 2001, Pages 3694-3704

  Murphy, Eric A ^a   Waring, Alan J ^b   Murphy, Jason C ^c   Willson, Richard C ^c   Longmuir, Kenneth J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of Houston   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; DIMYRISTOYLPHOSPHATIDYLETHANOLAMINE; DNA; ETHANOLAMINE DERIVATIVE; LIPOFECTAMINE; LUCIFERASE; NUCLEASE; PEPTIDE; PEPTIDE DERIVATIVE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; PLASMID DNA; POLYETHYLENEIMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA SYNTHESIS; DOSE RESPONSE; DRUG EFFICACY; ENDOSOME; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; TECHNOLOGY;

ANIMALIA;

EID: 0035445126     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.17.3694     Document Type: Article

References (43)

1. DNA condensation
2. Nomenclature for synthetic gene delivery systems
3. Cellular and molecular barriers to gene transfer by a cationic lipid
4. Mitosis enhances transgene expression of plasmid delivered by cationic liposomes
5. Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure
6. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection
7. Stabilized plasmid-lipid particles for systemic gene therapy
8. Improved DNA: Liposome complexes for increased systemic delivery and gene expression
9. Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery
10. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes
11. Cationic liposome-mediated intravenous gene delivery
12. Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery
13. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine
14. Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells
15. Gene transfer into mammalian cells using histone-condensed plasmid DNA
16. A physicochemical approach for predicting the effectiveness of peptide-based gene delivery systems for use in plasmid-based gene therapy
17. Branched cationic peptides for gene delivery: Role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes
18. Peptide-mediated gene delivery: Influence of peptide structure on gene expression
19. In vivo delivery to tumors of DNA complexed with linear polyethylenimine
20. Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse
21. Polyethylenimine-mediated gene transfer into pancreatic tumor dissemination in the murine peritoneal cavity
22. Compaction of DNA in an anionic micelle environment followed by assembly into phosphatidylcholine liposomes
23. Purification of plasmid DNA using selective precipitation by compaction agents
24. Quantitative analysis of phospholipids by thin layer chromatography and phosphorus analysis of spots
25. A simplified protein assay with fluorescamine in samples containing interfering material
26. Solvation energies of amino acid side chains and backbone in a family of host-guest pentapeptides
27. Peptide-based gene delivery
28. Membrane fusion intermediates
29. Membrane lipid molecular structure and polymorphism
30. Transferrin-polycation-mediated introduction of DNA into human leukemic cells: Stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels
31. Receptor-mediated endocytosis of transferrin-polycation conjugates: An efficient way to introduce DNA into hematopoietic cells
32. Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages
33. Weak bases and ionophores rapidly and reversibly raise the pH of endocytic vesicles in cultured mouse fibroblasts
34. Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents
35. 1
36. Putative role of chloroquine in gene transfer into a human hepatoma cell line by DNA/lactosylated polylysine complexes
37. Receptor-mediated endocytosis of immunoglobulin-coated colloidal gold particles in cultured mouse peritoneal macrophages. Chloroquine and monensin inhibit transfer of the ligand from endocytic vesicles to lysosomes
38. Monensin and chloroquine inhibit transfer to lysosomes of endocytosed macromolecules in cultured mouse peritoneal macrophages
39. DNA transfection mediated by cationic liposomes containing lipopolylysine: Characterization and mechanism of action
40. A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells
41. HIV-1 infection of non-dividing cells: Evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import
42. A peptide derived from the N-terminal region of HIV-1 Vpr promotes nuclear import in permeabilized cells: Elucidation of the NLS region of the Vpr
43. Viral protein R regulates nuclear import of the HIV-1 pre-integration complex