Identification of a novel C-terminal domain involved in the negative function of the rainbow trout Ah receptor nuclear translocator protein isoform a (rtARNTa) in Ah receptor-mediated signaling

Biochemical Pharmacology

Volumn 62, Issue 3, 2001, Pages 307-318

  Necela, Brian ^a   Pollenz, Richard S ^b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Ah receptor; ARNT; CYP1A1; Dominant negative; Gene regulation; Rainbow trout

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CARRIER PROTEIN; ISOPROTEIN; PROTEIN; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CARBOXY TERMINAL SEQUENCE; DIMERIZATION; DNA BINDING; HEPATOMA CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAINBOW TROUT; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; DIMERIZATION; DNA-BINDING PROTEINS; MUTAGENESIS; ONCORHYNCHUS MYKISS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ARYL HYDROCARBON; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 0035427502     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00671-2     Document Type: Article

References (38)

1. Cloning of a factor required for activity of the Ah (dioxin) receptor
2. The aryl hydrocarbon receptor complex
3. Induction of cytochrome P4501A1
4. Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression
5. Oxygen sensing and signaling: Impact on the regulation of physiologically important genes
6. Association of the Ah receptor with the 90-kDa heat shock protein
7. The aryl-hydrocarbon receptor, but not the aryl-hydrocarbon receptor nuclear translocator protein, is rapidly depleted in hepatic and nonhepatic culture cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
8. Aryl hydrocarbon receptor imported into the nucleus following ligand binding is rapidly degraded via the cytoplasmic proteasome following nuclear export
9. Protein kinase C modulates aryl hydrocarbon receptor nuclear translocator protein-mediated transactivation potential in a dimer context
10. Ah receptor nuclear translocator protein heterogeneity is altered after heterodimerization with the Ah receptor
11. Determination of aryl hydrocarbon receptor nuclear translocator protein concentration and subcellular localization in hepatic and nonhepatic cell culture lines: Development of quantitative western blotting protocols for calculation of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein in total cell lysates
12. Nuclear localization and export signals of the human aryl hydrocarbon receptor
13. Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role of LXXLL motifs
14. CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (ARNT)
15. The murine Sim-2 gene product inhibits transcription by active repression and functional interference
16. Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embyrogenesis
17. Isolation and expression of cDNAs from rainbow trout (Oncorhynchus mykiss) that encodes two novel basic-helix-loop-helix/PER-ARNT-SIM (bHLH/PAS) proteins with distinct functions in the presence of the aryl hydrocarbon receptor
18. Aryl hydrocarbon (Ah) nonresponsiveness in estrogen receptor-negative MDA-MB-231 cells is associated with expression of a variant arnt protein
19. Identification of a novel mechanism of regulation of Ah (dioxin) receptor function
20. Transcriptional repression in development
21. Functional analysis of activation and repression domains of the rainbow trout aryl hydrocarbon receptor nuclear translocator (rtARNT) protein isoforms
22. The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy
23. Analysis of the complex relationship between nuclear export and aryl hydrocarbon receptor-mediated gene regulation
24. Protein-DNA interactions at the dioxin-responsive promoter
25. Specific DNA binding of Gal4, a positive regulatory protein of yeast
26. Transcriptional activation function of the mouse Ah receptor nuclear translocator
27. Potent transactivation domains of the Ah receptor and the Ah receptor nuclear translocator map to their carboxyl termini
28. Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor ARNT: Inducible versus constitutive modes of regulation
29. Dimerization, DNA binding, and transactivation properties of the hypoxia-inducible factor 1
30. The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
31. Id helix-loop-helix proteins in cell growth and differentiation
32. Inhibitory transcription factors
33. Regulation of DNA binding activity and nuclear transport of B-Myb in Xenopus oocytes
34. Regulation of the DNA-binding and transcriptional activities of Xenopus laevis NFI-X by a novel C-terminal domain
35. Structure and expression of the mouse AhR nuclear translocator (mArnt) gene
36. ARNT-deficient mice and placental differentiation
37. Abnormal angiogenesis and response to glucose and oxygen deprivation in mice lacking the protein ARNT