Sex differences in opioid antinociception: κ and 'mixed action' agonists

Drug and Alcohol Dependence

Volumn 63, Issue 3, 2001, Pages 215-228

  Craft, Rebecca M ^a   Bernal, Scott A ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Opioids; Analgesia; Gender; Locomotor activity

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; BREMAZOCINE; BUTORPHANOL; ETHYLKETAZOCINE; HOT WATER; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALBUPHINE; OPIATE; PENTAZOCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; ESTRUS CYCLE; FEMALE; LOCOMOTION; MALE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SEDATION; SEX DIFFERENCE; TAIL; TEMPERATURE;

ADAPTATION, PHYSIOLOGICAL; ANALGESICS; ANALGESICS, OPIOID; ANALYSIS OF VARIANCE; ANIMALS; ESTRUS; FEMALE; LINEAR MODELS; MALE; MOTOR ACTIVITY; NOCICEPTORS; PAIN; RATS; RATS, SPRAGUE-DAWLEY; SEX CHARACTERISTICS;

ANIMALIA;

EID: 0035427469     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0376-8716(00)00209-X     Document Type: Article

References (64)

1. Sex-related differences in the effects of morphine and stress on visceral pain
2. Ovarian steroids and modulation of morphine-induced analgesia and catalepsy in female rats
3. Sex differences in opioid antinociception
4. Alterations in brain opiate receptor mechanisms on proestrus afternoon
5. Microinjection of morphine into rostral ventromedial medulla produces greater antinociception in male compared to female rats
6. Butorphanol: Characterization of agonist and antagonist effects in rhesus monkeys
7. κ-Opioid receptor binding populations in rhesus monkey brain: Relationship to an assay of thermal antinociception
8. Susceptibility to sensitization. I. Sex differences in the enduring effects of chronic D-amphetamine treatment on locomotion, stereotyped behavior and brain monoamines
9. Effect of adrenal and sex hormones on opioid analgesia and opioid receptor regulation
10. The opioid receptor binding of dezocine, morphine, fentanyl, butorphanol and nalbuphine
11. ( - )Pentazocine analgesia in mice: Interactions with a σ-receptor system
12. Gender-related differences in the antinociceptive properties of morphine
13. Sex-related differences in morphine's antinociceptive activity: Relationship to serum and brain morphine concentrations
14. Sex differences in development of morphine tolerance and dependence in the rat
15. Butorphanol, levallorphan, nalbuphine and nalorphine as antagonists in the squirrel monkey
16. Binding affinity and selectivity of opioids at μ, δ and κ-receptors in monkey brain membranes
17. Rat estrous cycles
18. The ovarian cycle in the rat
19. Butorphanol-mediated antinociception in mice: Partial agonist effects and μ-receptor involvement
20. Gender difference in analgesic response to the κ-opioid pentazocine
21. κ-Opioids produce significantly greater analgesia in women than in men
22. The κ-opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain
23. B agonist baclofen
24. μ-Opiate receptor binding in the medial preoptic area is cyclical and sexually dimorphic
25. Differential sensitivity of models of antinociception in the rat, mouse and guinea-pig to μ- and κ-opioid receptor agonists
26. Sex differences in N-methyl-D-aspartate involvement in κ-opioid and non-opioid predator-induced analgesia in mice
27. Sex and day-night differences in opiate-induced responses of insular wild deer mice, Peromyscus maniculatus triangularis
28. Roles of gender, gonadectomy and estrous phase in the analgesic effects of intracerebroventricular morphine in rats
29. Gender effects and central opioid analgesia
30. 2 analysis in rhesus monkeys
31. Morphine antinociception elicited from the ventrolateral periaqueductal gray is sensitive to sex and gonadectomy differences in rats
32. Properties of a selective κ-agonist, U-50488H
33. 3H]U-69593 a highly selective ligand for the opioid κ-receptor
34. Some gender differences in alcohol and polysubstance users
35. Sex differences in the inhibitory effects of the NMDA antagonist, MK-801, on morphine and stress-induced analgesia
36. Sex differences in the acquisition of intravenously self-administered cocaine and heroin in rats
37. Reinstatement of cocaine self-administration in rats: Sex differences
38. Anatomy of CNS opioid receptors
39. κ-Opioid receptor-mediated antinociception in the rat. I. Comparative actions of μ- and κ-opioids against noxious thermal, pressure and electrical stimuli
40. κ-Opioid receptor-mediated antinociception in the rat. II. Supraspinal in addition to spinal sites of action
41. μ-Opiate receptor binding is up-regulated in mice selectively bred for high stress-induced analgesia
42. Sex differences in thermal nociception and morphine antinociception in rodents depend on genotype
43. Stimulation of the periaqueductal gray matter inhibits nociception at the supraspinal as well as spinal level
44. Opioid antinociception in ovariectomized monkeys: Comparison with antinociception in males and effects of estradiol replacement
45. Affinity of drugs and peptides for U-69593-sensitive and -insensitive κ-opiate binding sites: The U-69593-insensitive site appears to be the β endorphin-specific epsilon receptor
46. Estrogen treatment to ovariectomized rats modifies morphine-induced behavior
47. Comparison of antinociceptive effects induced by κ-opioid agonists in male and female mice
48. Expression of μ, κ, and δ-opioid receptor messenger RNA in the human CNS: A 33P in situ hybridization study
49. Tolerance and cross-tolerance studies with morphine and ethylketazocine
50. Effects of estradiol and progesterone on the sensitivity to pain and on morphine-induced antinociception in female rats
51. Spinal κ-opioid receptor-mediated antinociception is stimulus-specific
52. κ-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system
53. The effects of gonadal hormones on the development and expression of the stimulant effects of morphine in male and female rats
54. Pentazocine-induced biphasic analgesia in mice
55. U-50488, a selective κ-opioid agonist: Comparison to other reputed κ-agonists
56. U-50488: A selective and structurally novel non-μ (κ) opioid agonist
57. Opioid thermal antinociception in rhesus monkeys: Receptor mechanisms and temperature dependency
58. 2 analysis for naltrexone antagonism of discriminative stimulus and analgesic effects of opiate agonists in rats
59. Estrogen and progesterone regulate opiate receptor densities in multiple brain regions
60. Differential involvement of opioid receptors in intrathecal butorphanol-induced analgesia: Compared to morphine
61. 35S]GTPγS binding to membranes: Determination of potencies and efficacies of ligands
62. Use of β-funaltrexamine to determine μ opioid receptor involvement in the analgesic activity of various opioid ligands
63. Gender and age influences on human brain μ-opioid receptor binding measured by PET