Microinjection of morphine into the rostral ventromedial medulla produces greater antinociception in male compared to female rats

Brain Research

Volumn 796, Issue 1-2, 1998, Pages 315-318

  Boyer, Jill S ^a   Morgan, Michael M ^a   Craft, Rebecca M ^b  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Analesia; Locomotion; Nucleus raphe magnus; Opioid; Pain modulation; Sex difference

Indexed keywords

MORPHINE;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; INTRACEREBRAL DRUG ADMINISTRATION; LOCOMOTION; MALE; MEDULLA OBLONGATA; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; RAPHE MAGNUS NUCLEUS; RAT; SEX DIFFERENCE;

ANIMALS; FEMALE; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; MORPHINE; MOTOR ACTIVITY; NARCOTICS; NOCICEPTORS; RATS; RATS, SPRAGUE-DAWLEY; SEX CHARACTERISTICS;

EID: 0032526578     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00353-9     Document Type: Article

References (31)

1. Akaike A., Shibata T., Satoh H., Tagaki H. Analgesia induced by microinjection of morphine into, and electrical stimulation of, the nucleus reticularis paragigantocellularis of rat medulla oblongata. Neuropharmacology. 17:1978;775-778.
2. Baamonde A.I., Hidalgo A., Andres-Trelles F. Sex-related differences in the effects of morphine and stress on visceral pain. Neuropharmacology. 28:1989;967-970.
3. Bartok R.E., Craft R.M. Sex differences in opioid antinociception. J. Pharmacol. Exp. Ther. 282:1997;769-778.
4. Basbaum A.I., Fields H.L. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Ann. Rev. Neurosci. 7:1984;309-338.
5. Bellgowan P.S., Helmstetter F.J. Neural systems for the expression of hypoalgesia during nonassociative fear. Behav. Neurosci. 110:1996;727-736.
6. Bodnar R.J., Romero M.-T., Kramer E. Organismic variables and pain inhibition: roles of gender and aging. Brain Res. Bull. 21:1988;947-953.
7. Cicero T.J., Nock B., Meyer E.R. Gender-related differences in the antinociceptive properties of morphine. J. Pharmacol. Exp. Ther. 279:1996;767-773.
8. Cicero T.J., Nock B., Meyer E.R. Sex-related differences in morphine's antinociceptive activity: relationship to serum and brain morphine concentration. J. Pharmacol. Exp. Ther. 282:1997;939-944.
9. Craft R.M., Kalivas P.W., Stratmann J.A. Sex differences in discriminative stimulus effects of morphine in the rat. Behav. Pharmacol. 7:1996;764-778.
10. M.S. Fanselow, The midbrain periaqueductal gray as a coordinator of action in response to fear and anxiety, in: A. Depaulis, R. Bandler (Eds.), The Midbrain Periaqueductal Gray Matter, Vol. 213, Plenum, New York, 1991, pp. 151-173.
11. Fields H.L., Malick A., Burstein R. Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla. J. Neurophysiol. 74:1995;1742-1759.
12. Gear R.W., Miaskowski C., Gordon N.C., Paul S.M., Heller P.H., Levine J.D. κ-opioids produce significantly greater analgesia in women than in men. Nat. Med. 2:1996;1248-1250.
13. Heinricher M.M., Morgan M.M., Fields H.L. Direct and indirect actions of morphine on medullary neurons that modulate nociception. Neuroscience. 48:1992;533-543.
14. Heinricher M.M., Morgan M.M., Tortorici V., Fields H.L. Disinhibition of off-cells and antinociception produced by an opioid action within the rostral ventromedial medulla. Neuroscience. 63:1994;279-288.
15. Islam A., Cooper M., Bodnar R. Interactions among aging, gender, and gonadectomy effects upon morphine antinociception in rats. Physiol. Behav. 54:1993;45-53.
16. Jacquet Y.F., Lajtha A. Paradoxical effects after microinjection of morphine in the periaqueductal gray matter in the rat. Science. 185:1974;1055-1057.
17. Jensen T.S., Yaksh T.L. I. Comparison of antinociceptive action of morphine in the periaqueductal gray medial and paramedial medulla in rat. Brain Res. 363:1986;99-113.
18. Kavaliers M., Innes D. Sex and day-night differences in opiate-induced responses of insular wild deer mice, Peromyscus maniculatus triangularis. Pharmacol. Biochem. Behav. 27:1987;477-482.
19. Kepler K.L., Kest B., Kiefel J.M., Cooper M.L., Bodnar R.J. Roles of gender, gonadectomy and estrous phase in the analgesic effects of intracerebroventricular morphine in rats. Pharmacol. Biochem. Behav. 34:1989;119-127.
20. Marks H.E., Hobbs S.H. Changes in stimulus reactivity following gonadectormy in male and female rats of different ages. Physiol. Behav. 8:1972;1113-1119.
21. Martin G.F., Vertes R.P., Waltzer R. Spinal projections of the gigantocellular reticular formation in the rat. Evidence for projections from different areas to laminae I and II and lamina IX. Brain Res. 58:1985;154-162.
22. Mogil J.S., Sternberg W.F., Kest B., Marek P., Liebeskind J.C. Sex differences in the antagonism of swim stress-induced analgesia: effects of gonadectomy and estrogen replacement. Pain. 53:1993;17-25.
23. M.M. Morgan, Differences in antinociception evoked from dorsal and ventral regions of the caudal periaqueductal gray matter, In: A. Depaulis, R. Bandler (Eds.), The Midbrain Periaqueductal Gray Matter, Vol. 213, Plenum, New York, 1991, pp. 139-150.
24. Morgan M.M., Heinricher M.M., Fields H.L. Circuitry linking opioid-sensitive nociceptive modulatory systems in periaqueductal gray and spinal cord with rostral ventromedial medulla. Neuroscience. 47:1992;863-871.
25. Morgan M.M., Whitney P.K., Thompson M.E., Springmeyer L. Antinociception and immobility produced by microinjection of low doses of kainic acid into the RVM of the rat. Soc. Neurosci. Abstr. 21:1995;1639.
26. Pare W.P. Age, sex and strain differences in the aversive threshold to grid shock in the rat. J. Comp. Physiol. Psychol. 69:1969;214-218.
27. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, 2nd edn., Academic Press, Sydney, 1986.
28. Proudfit H.K. Time-course of alterations in morphine-induced analgesia and nociceptive threshold following medullary raphe lesions. Neuroscience. 6:1981;945-951.
29. Rivot J.P., Chaouch A., Besson J.M. Nucleus raphe magnus modulation of responses of rat dorsal horn neurons to unmyelinated fiber inputs: partial involvement of serotonergic pathways. J. Neurophysiol. 44:1980;1039-1057.
30. Watkins L.R., Young E.G., Kinscheck I.B., Mayer D.J. The neural basis of footshock analgesia: the role of specific ventral medullary nuclei. Brain Res. 276:1983;305-315.
31. Young E.G., Watkins L.R., Mayer D.J. Comparison of the effects of ventral medullary lesions on systemic and microinjection morphine analgesia. Brain Res. 290:1984;119-129.