Two HLA DRB 1 alleles confer independent genetic susceptibility to graves disease: Relevance of cross-population studies

American Journal of Medical Genetics

Volumn 102, Issue 2, 2001, Pages 188-191

  Marga, Mara ^a   Denisova, Alla ^b   Sochnev, Artur ^b   Pirags, Valdis ^b   Farid, Nadir R ^a,b  

^a RIGA STRADINS UNIVERSITY   (Latvia)

^b Osancor Biotech Inc   (United Kingdom)

Author keywords

Genetics; Graves disease; HLA DRB1; Latvia

Indexed keywords

HLA DR2 ANTIGEN;

ADOLESCENT; ADULT; AGED; ALLELE; ALPHA HELIX; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CLINICAL ARTICLE; FEMALE; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GRAVES DISEASE; HLA SYSTEM; HUMAN; LATVIA; MALE; POPULATION RESEARCH; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ALLELES; DNA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GRAVES DISEASE; HLA-DR ANTIGENS; HUMANS; MALE; MIDDLE AGED; ODDS RATIO;

EID: 0035425598     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajmg.1431     Document Type: Article

References (22)

1. HLA and Graves' disease: An association with HLA-Dw3
2. Susceptibility and resistance alleles of human leucocyte antigen (HLA) DQA1 and HLA DQB1 are shared in endocrine autoimmune disease
3. Management of Graves' opthalmopathy: Reality and perspectives
4. HLA-DRB1*08, DRB1*03/DRB3*0101, and DRB3*0202 are susceptibility genes for Graves' disease in North American caucasians, whereas DRB1*07 is protective
5. Lack of independent association between the human leukocyte antigen allele DQA1*0501 and Graves' disease
6. Graves' disease
7. The genetics of thyroid associated opthalmopathy
8. Graves' disease
9. Graves' disease and HLA: Clinical and epidemiological associations
10. Major histocompactibility complex (MHC) factors predisposing to and protecting against Graves' eye disease
11. Molecular basis for HLA-DQ association with IDDM
12. Relative predispositional effects (RPEs) of marker alleles with disease: HLA-DR alleles and Graves' disease
13. Searching for genetic determinants in the new millenium
14. HLA class II genes in Latvian patients with juvenile rheumatoid arthritis
15. Post-partum thyroiditis and goitrous (Hashimoto's) thyroiditis are associated with HLA-DR4
16. The genetic susceptibility to Graves' disease
17. Mapping the major susceptibility loci for familial Graves' and Hashimoto diseases: Evidence of genetic heterogeneity and gene interactions
18. The epidemiology of thyroid disease
19. The cytotoxic T-lymphocytes antigen-4 is a major Graves' disease locus
20. Evidence for a new Graves' disease susceptibility locus at chromosome 18q21
21. Strong association between HLA-DQA1*0501 and Graves' disease in a male Caucasian population
22. Primary role of the HLA class II DRB1*0301 allele in Graves' disease