Differences in the expression of human class I MHC alleles and their associated peptides in the presence of proteasome inhibitors

Journal of Immunology

Volumn 167, Issue 3, 2001, Pages 1212-1221

  Luckey, C J ^a   Marto, J A ^a   Partridge, M ^a   Hall, E ^a   White, F M ^a   Lippolis, J D ^a   Shabanowitz, J ^a   Hunt, D F ^a   Engelhard, V H ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME INHIBITOR;

ALLELE; ALLELISM; ANTIGEN EXPRESSION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CONCENTRATION RESPONSE; CORRELATION FUNCTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN MOTIF;

EID: 0035422908     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.3.1212     Document Type: Article

References (61)

1. Mechanisms of MHC class I-restricted antigen processing
2. Degradation of cell proteins and the generation of MHC class I-presented peptides
3. MHC class I expression in mice lacking the proteasome subunit LMP-7
4. Altered peptidase and viral-specific T cell response in LMP2 mutant mice
5. Antigen presentation by MHC class I and its regulation by interferon γ
6. Chemical denaturation and modification of ovalbumin alters its dependence on ubiquitin conjugation for class I antigen presentation
7. The Listeria monocytogenes-secreted p60 protein is an n-end rule substrate in the cytosol of infected cells: Implications for major histocompatibility complex class I antigen processing of bacterial proteins
8. Peptide antigen production by the proteasome-complexity provides efficiency
9. The proteolytic fragments generated by vertebrate proteasomes: Structural relationships to major histocompatibility complex class I binding peptides
10. Effects of major-histocompatibility-complex-encoded subunits on the peptidase and proteolytic activities of human 20S proteasomes: Cleavage of proteins and antigenic peptides
11. The effect of the proteasome inhibitor lactacystin on the presentation of transporter associated with antigen processing (TAP)-dependent and TAP-independent peptide epitopes by class I molecules
12. Proteasome activity limits the assembly of MHC class I molecules after IFN-γ stimulation
13. Genes regulating MHC class I processing of antigen
14. Presentation of endogenous and exogenous antigens is not affected by inactivation of El ubiquitin-activating enzyme in temperature-sensitive cell lines
15. The generation of MHC class I associated peptides is only partially inhibited by proteasome inhibitors: Involvement of nonproteasomal cytosolic proteases in antigen processing
16. Reading within the lines: Naturally processed peptides displayed by MHC class I molecules
17. Allelic differences in the relationship between proteasome activity and MHC class I peptide loading
18. Point mutation flanking a CTL epitope ablates in vitro and in vivo recognition of a full-length viral protein
19. Proteasomes can either generate or destroy MHC class I epitopes: Evidence for nonproteasomal epitope generation in the cytosol
20. A proteolytic system that compensates for loss of proteasome function
21. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
22. Lactacystin and clasto-lactacystin β-lactone modify multiple proteasome β-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation
23. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
24. Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HsIV by a new class of inhibitors
25. Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes
26. Mutations that impair a posttranscriptional step in expression of HLA-A and -B antigens
27. Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport
28. Identification by site-directed mutagenesis of amino acid residues contributing to serologic and CTL-defined epitope differences between HLA-A2.1 and HLA-A2.3
29. Partial purification and some properties of BB7.2: A cytotoxic monoclonal antibody with specificity for HLA-A2 and a variant of HLA-A28
30. Monoclonal antibodies for analysis of the HLA system
31. Description of monoclonal antibody defining an HLA allotypic determinant that includes specificities within the B5 cross-reacting group
32. A monoclonal antibody directed against the HLA-Bw6 epitope
33. Use of a monoclonal antibody (W6/32) in structural studies of HLA-A,B,C antigens
34. Sub-femtomole MS and MS/MS peptide sequence analysis using nano-HPLC micro-ESI Fourier transform ion cyclotron resonance mass spectrometry
35. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database
36. Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules
37. Transfer of cloned human class I major histocompatibility complex genes into HLA mutant human lymphoblastoid cells
38. HLA-A2.1 associated peptides from a mutant cell line: A second pathway of antigen presentation
39. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides
40. Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex
41. Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum
42. Discrete proteolytic intermediates in the MHC class I antigen processing pathway and MHC I-dependent peptide trimming in the ER
43. Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides
44. Trimming of antigenic peptides in an early secretory compartment
45. TAP (transporter associated with antigen processing)-independent presentation of endogenously synthesized peptides is enhanced by endoplasmic reticulum insertion sequences located at the amino- but not carboxyl-terminus of the peptide
46. Presentation of endogenous peptide/MHC class I complexes is profoundly influenced by specific C-terminal flanking residues
47. NK susceptibility varies inversely with target cell class I HLA antigen expression
48. Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle
49. HLA-A2 subtypes are functionally distinct in peptide binding and presentation
50. Differences in peptide-binding specificity of two ankylosing spondylitis-associated HLA-B27 subtypes
51. Binding of peptides naturally presented by HLA-B27 to the differentially disease-associated B*2704 and B*2706 subtypes, and to mutants mimicking their polymorphism
52. The class I antigen processing pathway for the membrane protein tyrosinase involves translation in the endoplasmic reticulum and processing in the cytosol
53. Identification of a TAP-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen
54. Introduction of a glycosylation site into a secreted protein provides evidence for an alternative antigen processing pathway: Transport of precursors of major histocompatibility complex class I-restricted peptides from the endoplasmic reticulum to the cytosol
55. MHC ligands and peptide motifs: First listing
56. Dominant aromatic/aliphatic C-terminal anchor in HLA-B*2702 and B*2705 peptide motifs
57. Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing
58. Covalent modification of the active site threonine of proteasomal β subunits and the Escherichia coli homolog HslV by a new class of inhibitors
59. Contribution of proteasomal β-subunits to the cleavage of peptide substrates analyzed with yeast mutants
60. A giant protease with potential to substitute for some functions of the proteasome