Inhibition of angiogenesis induces chromaffin differentiation and apoptosis in neuroblastoma

American Journal of Pathology

Volumn 154, Issue 2, 1999, Pages 395-403

  Wassberg, Erik ^a   Hedborg, Fredrik ^b   Sköldenberg, Erik ^a,b   Stridsberg, Mats ^b   Christofferson, Rolf ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; FUMAGILLOL CHLOROACETYLCARBAMATE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CHROMAFFIN CELL; HUMAN; HUMAN CELL; METASTASIS; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TUMOR CELL LINE; TUMOR GROWTH; TUMOR VASCULARIZATION;

EID: 0032964898     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65286-8     Document Type: Article

References (43)

1. Folkman J: Tumor angiogenesis: therapeutic implications. N Engl J Med 1971, 285:1182-1186
2. Folkman J: Tumor angiogenesis. The Molecular Basis of Cancer. Edited by J Mendelsohn, PM Howley, MA Israel, LA Liotta. Philadelphia, WB Saunders. 1995, pp 206-232
3. Brem H, Folkman J: Analysis of experimental antiangiogenic therapy. J Pediatr Surg 1993, 28:445-451
4. O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH, Folkman J: Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994, 79:315-328
5. O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J: Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 1997, 88:277-285
6. Teicher BA: A systems approach to cancer therapy (Antiangiogenics + standard cytotoxics → mechanism(s) of interaction). Cancer Metastasis Rev 1996, 15:247-272
7. Teicher BA, Emi Y, Kakeji Y, Northey D: TNP-470/Minocycline/Cytotoxic therapy: a systems approach to cancer therapy. Eur J Cancer 1996, 32A:2461-2466
8. Ingber D, Fujita T, Kishimoto S, Sudo K, Kanamaru T, Brem H, Folkman J: Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth. Nature 1990, 348:555-557
9. Antoine N, Greimers R, De Roanne C, Kusaka M, Heinen E, Simar L J, Castronovo V: AGM-1470, a potent angiogenesis inhibitor, prevents the entry of normal but not transformed endothelial cells into the G1 phase of the cell cycle. Cancer Res 1994, 54:2073-2076
10. Castronovo V, Belotti D: TNP-470 (AGM-1470): Mechanisms of action and early clinical development. Eur J Cancer 1996, 32A:2520-2527
11. Holmgren L, O'Reilly MS, Folkman J: Dormancy of micrometastases balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med 1995, 1:149-153
12. O'Reilly MS, Holmgren L, Chen C, Folkman J: Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 1996, 2:689-692
13. Berthold F: Biology of neuroblastoma. Neuroblastoma: Tumor Biology and Therapy. Edited by C Pochedly, Boca Raton, CRC Press, 1990, pp 1-27
14. Brodeur GM, Maris JM, Yamashiro DJ, Hogarty MD, White PS: Biology and genetics of human neuroblastomas. J Pediatr Hematol Oncol 1997, 19:93-101
15. Hedborg F, Ohlsson R, Sandstedt B, Grimelius L, Hoehner J, Påhlman S: IGF2 expression is a marker for paraganglionic/SIF cell differentiation in neuroblastoma. Am J Pathol 1995, 146:833-847
16. Wassberg E, Påhlman S, Westlin J-E, Christofferson R: The angiogenesis inhibitor TNP-470 reduces the growth rate of human neuroblastoma in nude rats. Pediatr Res 1997, 41:327-333
17. Biedler JL, Roffler-Tarlov S, Schachner M, Freedman LS: Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res 1978, 38:3751-3757
18. Christofferson RH, Nilsson BO: Microvascular corrosion casting with analysis in the scanning electron microscope. Scanning 1988, 10: 43-63
19. Rentrop M, Knapp B, Winter H, Schweizer J. Aminoalkylsilane-treated glass slides as support for in situ hybridization of keratin cDNAs to frozen tissue sections under varying fixation and pretreatment conditions. Histochem J 1986, 18:271-276
20. Ohlsson R, Holmgren L, Glaser A, Szpecht A, Pfeifer-Ohlsson S: Insulin-like growth factor 2 and short-range stimulatory loops in control of human placental growth. EMBO J 1989, 8:1993-1999
21. Hayes CE, Goldstein IJ: An α-D-galactosyl-binding lectin from Bandeiraea simplicifolia seeds: Isolation by affinity chromatography and characterization. J Biol Chem 1974, 249:1904-1914
22. Cattoretti G, Becker MHG, Key G, Duchrow M, Schluter C, Galle J, Gerdes J: Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 1992, 168: 357-363
23. Gestblom C, Hoehner JC, Hedborg F, Sandstedt B, Påhlman S: In vivo spontaneous neuronal to neuroendocrine lineage conversion in a subset of neuroblastomas. Am J Pathol 1997, 150: 107-117
24. Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 1992, 119:493-501
25. Weibel ER: Stereological Methods. London, Academic Press, 1979
26. Gundersen HJG, Bendtsen TF, Korbo L, Marcussen N, Møller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sørensen FB, Vesterby A, West MJ: Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 1988, 96: 379-394
27. Nagabuchi E, VanderKolk WE, Une Y, Ziegler MM: TNP-470 antiangiogenic therapy for advanced murine neuroblastoma. J Pediatr Surg 1997, 32:287-293
28. Parangi S, O'Reilly MS, Christofori G, Holmgren L, Grosfeld J, Folkman J, Hanahan D: Antiangiogenic therapy of transgenic mice impairs de novo tumor growth. Proc Natl Acad Sci USA 1996, 93:2002-2007
29. Isobe N, Uozumi T, Kurisu K, Kawamoto K: Antitumor effect of TNP-470 on glial tumors transplanted in rats. Anticancer Res 1996, 16: 71-76
30. Shimizu S, Eguchi Y, Kamiike W, Itoh Y, Hasegawa J, Yamabe K, Otsuki, Y, Matsuda H, Tsujimoto Y: Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bel-XL. Cancer Res 1996, 56:2161-2166
31. Shweiki D, Itin A, Soffer D, Keshet E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992, 359:843-845
32. Hanahan D, Folkman J: Patterns and emerging mechanisms of the angiogenic switch during angiogenesis. Cell 1996, 86:353-364
33. Kim KW, Bae SK, Lee OH, Bae MH, Lee MJ, Park BC: Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma. Cancer Res 1998, 58:348-351
34. Lu C, Tanigawa N. Spontaneous apoptosis is inversely related to intratumoral microvessel density in gastric carcinoma. Cancer Res 1997, 57:221-224
35. Folkman J: Tumor angiogenesis and tissue factor. Nat Med 1996, 2:167-168
36. Eves EM Boise LH, Thompson CB, Wagner AJ, Hay N, Rosner MR: Apoptosis induced by differentiation or serum deprivation in an immortalized central nervous system neuronal cell line. J Neurochem 1996, 67:1908-1920
37. Woods WG, Tuchman M, Robison LL, Bernstein M, Leclerc JM, Brisson LC, Brossard J, Hill G, Shuster J, Luepker R, Byrne T, Weitzman S, Bunin G, Lemieux B: A population-based study of the usefulness of screening for neuroblastoma. Lancet 1996, 348:1682-1687
38. Joshi VV, Cantor AB, Altshuler G, Larkin EW, Neill JSA, Shuster JJ, Holbrook CT, Hayes FA, Nitschke R, Duncan MH, Shochat SJ, Talbert J, Smith EI, Castieberry RP: Age-linked prognostic categorization based on a new histologic grading system of neuroblastomas. Cancer 1992, 69:2197-2211
39. Hoehner JC, Hedborg F, Wiklund HJ, Olsen L, Påhlman S: Cellular death in neuroblastoma: in situ correlation of apoptosis and bcl-2 expression. Int J Cancer 1995, 62:19-24
40. Hoehner JC, Gestblom C, Hedborg F, Sandstedt B, Olsen L, Påhlman S: A developmental model of neuroblastoma: differentiating stromapoor tumors' progress along an extra-adrenal chromaflin lineage. Lab Invest 1996, 75:659-675
41. Påhlman S, Hoehner JC, Nånberg E, Hedborg F, Fagerström S, Gestblom C, Johansson I, Larsson U, Lavenius E, Örtoft E, Söderholm H: Differentiation and survival influences of growth factors in human neuroblastoma. Eur J Cancer 1995, 31A:453-458
42. Wassberg E, Stridsberg M, Christofferson R: Plasma levels of chromogranin A are directly proportional to tumour burden in neuroblastoma. J Endocrinol 1996, 151:225-230
43. Stridsberg M, Hellman U, Wilander E, Lundqvist G, Hellsing K, Öberg K: Fragments of chromogranin A are present in the urine of patients with carcinoid tumours: Development of a specific radioimmunoassay for chromogranin A and its fragments J Endocrmol 1993, 139:329-337