p63 expression is associated with p53 loss in oral-esophageal epithelia of p53-deficient mice

Cancer Research

Volumn 61, Issue 17, 2001, Pages 6467-6473

  Suliman, Yasir ^a,b   Opitz, Oliver G ^c,e   Avadhani, Anjali ^c   Burns, Timothy C ^b   El Deiry, Wafik ^b   Wong, David T ^d   Rustgi, Anil K ^b,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c University of Freiburg ^*

^d HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^e UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; PROTEIN P63; PROTEIN P73;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL FUNCTION; CONTROLLED STUDY; DISEASE ASSOCIATION; ESOPHAGUS CARCINOMA; ESOPHAGUS MUCOSA; GENE EXPRESSION; GENE STRUCTURE; MOUSE; MOUTH CARCINOMA; MOUTH MUCOSA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SQUAMOUS EPITHELIUM; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DNA-BINDING PROTEINS; EPITHELIUM; ESOPHAGUS; GENES, P53; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MICE; MOUTH MUCOSA; PHOSPHOPROTEINS; TRANS-ACTIVATORS; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0035418620     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. The p53 tumour suppressor gene
2. p53, the cellular gatekeeper for growth and division
3. p63 and p73: p53 mimics, menaces and more
4. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
5. The emerging p53 gene family
6. Cloning and functional analysis of human p51, which structurally and functionally resembles p53
7. Expression of the p53 homologue p63α and ΔNp63α in normal and neoplastic cells
8. p63 and p73: Old members of a new family
9. From p63 to p53 across p73
10. The transcriptional activities of p53 and its homologue p51/p63: Similarities and differences
11. Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homologue Ket to mouse chromosome 16
12. p51A (TAp63g), a p53 homolog, accumulates in response to DNA damage for cell regulation
13. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53
14. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain
15. Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers
16. Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome
17. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
18. p63 is a p53 homologue required for limb and epidermal morphogenesis
19. The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach
20. A transgenic mouse model with cyclin DI overexpression results in cell cycle, epidermal growth factor receptor, and p53 abnormalities
21. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes
22. p63 identifies keratinocyte stem cells