Analysis of p53 mutation and expression in pleomorphic xanthoastrocytoma

Neurogenetics

Volumn 3, Issue 3, 2001, Pages 159-162

  Giannini, Caterina ^a   Hebrink, Deanne ^a   Scheithauer, Bernd W ^a   Dei Tos, Angelo P ^b   James, Charles D ^a  

^a MAYO CLINIC   (United States)

^b Treviso General Hospital   (Italy)

Author keywords

Anaplasia; p53; Pleomorphic xanthoastrocytoma; Tumor progression

Indexed keywords

PROTEIN P53;

ARTICLE; ASTROCYTOMA; EXON; GENETICS; HETEROZYGOTE; HUMAN; IMMUNOHISTOCHEMISTRY; MUTATION; POLYMERASE CHAIN REACTION;

ASTROCYTOMA; EXONS; HETEROZYGOTE; HUMANS; IMMUNOHISTOCHEMISTRY; MUTATION; POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035403576     PISSN: 13646745     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100480100116     Document Type: Article

References (20)

1. Kepes JJ, Louis DN, Giannini C, Paulus W (2000) Pleomorphic xanthoastrocytoma. In: Kleihues P, Cavenee WK (eds) Pathology and genetics of tumours of the nervous system. International Agency for Research on Cancer, Lyon, pp 52-54
2. Giannini C, Scheithauer BW, Burger PC, et al (1999) Pleomorphic xanthoastrocytoma: what do we really know about it? Cancer 85:2033-2045
3. Sawyer JR, Roloson GJ, Chadduck WM, Boop FA (1991) Cytogenetic findings in a pleomorphic xanthoastrocytoma. Cancer Genet Cytogenet 55:225-230
4. Li YS, Ramsay DA, Fan YS, et al (1995) Cytogenetic evidence that a tumor suppressor gene in the long arm of chromosome 1 contributes to glioma growth. Cancer Genet Cytogenet 84:46-50
5. Hollstein M, Sidransky D, Vogelstein B, Harris CC. (1991) p53 mutations in human cancers. Science 253:49-53
6. Bogler O, Huang HJS, Kleihues P, Cavenee WK (1995) The p53 gene and its role in human brain tumours. Glia 15:308-327
7. Paulus W, Lisle DK, Tonn JC, et al (1996) Molecular genetic alterations in pleomorphic xanthoastrocytoma. Acta Neuropathol (Berl) 91:293-297
8. Munoz EL, Eberhard DA, Lopes MBS, et al (1996) Proliferative activity and p53 mutation as prognostic indicators in pleomorphic xanthoastrocytoma. A clinicopathological study of 6 cases. J Neuropathol Exp Neurol 55:606
9. Louis DN, Deimling A von, Chung RY, et al (1993) Comparative study of p53 gene and protein alteration in human astrocytic tumors. J Neuropathol Exp Neurol 52:31-38
10. Kleihues P, Cavenee WK (2000) Pathology and genetics of tumours of the nervous system, vol. 253. International Agency for Research on Cancer, Lyon
11. Dei Tos AP, Doglioni C, Piccinin S, et al (1997) Molecular aberrations of the G1-S cell cycle checkpoint in myxoid and round cell liposarcoma. Am J Pathol 151:1531-1539
12. Raffel C, Frederick L, O'Fallon JR, et al (1999) Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations. Clin Cancer Res 5:4085-4090
13. Kosel S, Scheithauer BW, Graeber MB (2001) Genotype-phenotype correlation in gemistocytic astrocytomas. Neurosurgery 48:187-197
14. James CD, Galanis E, Frederick L, et al (1999) Tumor suppressor gene alterations in malignant gliomas: histopathological associations and prognostic evaluation. Int J Oncol 15: 547-553
15. Prayson RA, Morris HH (1998) Anaplastic pleomorphic xanthoastrocytoma. Arch Pathol Lab Med 122:1082-1086
16. Hernandez-Boussard T R-TP, Montesano R, Hainaut P (1999) IARC p53 muation database: a relational database to compile and analyze p53 mutations in human tumors and cell lines. International Agency for Research on Cancer. Hum Mutat 14: 1-8
17. Ohgaki H, Eibl RH, Schwab M, et al (1993) Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system. Mol Carcinog 8:74-80
18. Lang FF, Miller DC, Pisharody S, et al (1994) High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas. Oncogene 9:949-954
19. Patt S, Gries H, Giraldo M, et al (1996) p53 gene mutations in human astrocytic brain tumors including pilocytic astrocytomas. Hum Pathol 27:586-589
20. Hayes V, Clemens MF, Anke D, et al (1999) High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors. Brain Pathol 9:463-467