Lactate-induced inhibition of glucose catabolism in guinea pig cortical brain slices

Neurochemistry International

Volumn 35, Issue 5, 1999, Pages 405-409

  Griffin, J L ^a   Rae, C ^b   Radda, G K ^a   Matthews, P M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Ischaemia; Lactate; Metabolism; Pyruvate carboxylase; TCA cycle

Indexed keywords

LACTIC ACID; PYRUVATE DECARBOXYLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN SLICE; CITRIC ACID CYCLE; CONTROLLED STUDY; EPILEPSY; GLIA; GLUCOSE METABOLISM; GLYCOLYSIS; GUINEA PIG; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL TRANSPORT; CARBON ISOTOPES; CEREBRAL CORTEX; GLUCOSE; GUINEA PIGS; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; OXYGEN; PYRUVATE CARBOXYLASE;

CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0032782520     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(99)00085-6     Document Type: Article

References (20)

1. 13C-NMR spectroscopy. Biochem. J. 266:1990;133-139.
2. Balazs R. Carbohydrate metabolism. Lajtha A. Handbook of Neurochemistry. vol. 3:1970;1-36 Plenum, New York.
3. Bersin R.M., Stacpoole P.W. Dichloracetate as metabolic therapy for myocardial ischemia and failure. Am. Heart J. 134:1997;841-855.
4. Brand A., Engelmann J., Leibfritz D. A 13C NMR study on fluxes into the TCA cycle of neuronal and glial tumor cell lines and primary cells. Biochemie. 74:1992;941-948.
5. Feeney D.M., Baron J-C. Diaschisis. Stroke. 17:1986;817-828.
6. Flynn C.J., Farooqui A.A., Horrocks L.A. Ischemia and Hypoxia. Siegel G., Agranoff B., Albers R.W., Molinoff P. Basic Neurochemistry. 4th ed. 1989;Raven Press, New York.
7. Kaufman E.K., Driscoll B.F. CO2 fixation in neuronal and astroglial cells in culture. J. Neurochem. 58:1992;258-262.
8. Larabee M.J. Lactate metabolism and its effects on glucose metabolism in an excised neural tissue. J. Neurochem. 64:1995;1734-1741.
9. McIlwain, H., Bachelard, H.S. 1985. Biochemistry and the Central Nervous System, 5th ed. Churchill-Livingstone, Edinburgh, UK, 40-41, 54-59.
10. Magistretti P.J. Coupling of cerebral blood flow and metabolism. Welch K.M.A., Caplan L.R., Reis D.J., Siesjo B.K., Wier B. Primer on Cardiovascular Diseases. 1997;Academic Press, Sandiego.
11. Nemoto E.M. Brain ischaemia. Lajtha A. Alterations of Metabolites in the Nervous System (Handbook of Neurochemistry. vol. 9:1985;553-588 Plenum, New York.
12. Passonneau J.V., Lowry O.H. Enzymatic Analysis. 1993;The Humana Press Inc, New Jersey. Chapter 6.
13. 2 fixing enzymes in the metabolism of rat brain. J. Neurochem. 22:1974;717-724.
14. Prichard J.W. Nuclear magnetic resonance spectroscopy of seizure states. Epilepsia. 35:1994;S14-S20.
15. 1H NMR in human visual cortex during physiological stimulation. Proc. Natl. Acad. Sci., USA. 88:1991;5829-5831.
16. Rodnight R., McIlwain H. Techniques in tissue metabolism. Biochem. J. 57:1954;649-661.
17. Russell R.R., Taegtmeyer H. Changes in citric acid cycle flux and anaplerosis antedate the functional decline in isolated rat hearts utilizing acetoacetate. J. Clin. Invest. 87:1991;384-390.
18. Russell R.R., Taegtmeyer H. Pyruvate carboxylation prevents the decline in contractile function of rat hearts oxidising acetoacetate. Am. J. Physiol. 261:1991;H1756-H1762.
19. Shaka A.J., Keeler J., Freeman R. Evaluation of a new broadband decoupling sequence: WALTZ-16. J. Magn. Reson. 53:1983;313-340.
20. 13C]glucose metabolism. J. Neurochem. 61:1993;315-323.